Physical Stability of Rivaroxaban Loaded Liposomes Coated with Low Molecular Weight Chitosan

Abstract

The purpose of this study is to evaluate the improvement in physical stability of Chitosan (CS) coated liposomes. Small unilamellar classic liposomes (RIV-CLs) and flexible liposomes (RIV-FLs) loaded with rivaroxaban (RIV) were coated with low molecular weight chitosan (LMW CS) by simply mixing the liposomal suspension with the acidic polymer solutions of varying strengths. Changes in particle size and zeta potential for CS coated liposomes confirmed the existence of a thick polymer layer on the surface of liposomes which was also manifested from the TEM images. The physical stability of CS coated liposomes was evaluated by measuring the change in particle size, zeta potential, in vitro drug release and the retention of entrapped contents after periods of storage.