Central activities of hydroalcoholic extract from Lafoensia pacari A. St.-Hil. stem bark

Galdino, Pablinny Moreira; Nascimento, Marcus Vinícius Mariano; Sousa, Fábio Borges de; Ferreira, Reginaldo Nassar; Paula, José Realino de; Costa, Élson Alves

doi:10.1590/s1984-82502010000300008

Cited by 8 publications

(7 citation statements)

References 27 publications

(24 reference statements)

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“…bergamia essential oil is involved with a noradrenergic component in the hypothalamic-pituitary-adrenal axis that reduce corticosterone levels [7]. While the S. odoratissima anxiolytic effect seems to be related to the serotonergic system, which may be mediated by 5-HT1A receptors since NAN-190 reversed the buspirone and the studied essential oil effects [56].…”

Section: Discussionmentioning

confidence: 95%

Citrus limon (L.) Burm f. Essential Oil Has Anxiolytic and Sedative Properties by Modulating GABAA-Receptors

Viana

Neto

Lima

et al. 2020

Braz. arch. biol. technol.

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The high prevalence of anxiety disorders associated with pharmacotherapy side effects have motivated the search for new pharmacological agents. Species from Citrus genus, such as Citrus limon (sicilian lemon), have been used in folk medicine as a potential therapy to minimize emotional disorders. In order to searching for new effective treatments with fewer side effects, the present study evaluated the anxiolytic mechanism of action and the hypnotic-sedative activity from the Citrus limon fruit's peels essential oil (CLEO). Adults male Swiss mice were submitted to barbiturate-induced sleep test; elevated plus-maze (EPM) and light-dark box (LDB) (evaluation of the mechanism of action); rotarod; and catalepsy tests. CLEO oral treatment decreased latency and increased the sleep total time; moreover it induced in animals an increased the number of entries and percentage of time spent into open arms of the EPM; an increased the number of transitions and the percentage of time into light compartment in the LDB; which were only antagonized by flumazenil pretreatment, with no injury at motor function. Thus, results suggest that CLEO treatment induced an anxiolytic behavior suggestively modulated by the benzodiazepine binding site of the GABAA receptor or by an increase of GABAergic neurotransmission, without cause impairment in the motor coordination. HIGHLIGHTS  Essential oils from Citrus genus induce anxiolytic-like effects;  Citrus limon essential oil acts as hypnotic-sedative and anxiolytic drug;  GABAergic pathway is suggestively related to Citrus limon essential oil action;  No motor impairment was observed with Citrus limon essential oil.  2 Viana, M.D.M..; et al.

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Section: Discussionmentioning

confidence: 95%

Citrus limon (L.) Burm f. Essential Oil Has Anxiolytic and Sedative Properties by Modulating GABAA-Receptors

Viana

Neto

Lima

et al. 2020

Braz. arch. biol. technol.

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“…In the assessment of the antisecretory activity, three doses were initially chosen for LAF, based on Galdino et al (2010). LAF (75, 150, and 300 mg/kg) and ranitidine reduced the volume of gastric secretion by 9.64, 11.2, 15.66, and 9.24%, respectively, compared to the control group.…”

Section: Resultsmentioning

confidence: 99%

Gastroprotective activity of punicalagin and Lafoensia pacari in mice

Chaibub

Martins

Paula

et al. 2020

Rev. Bras. Farmacogn.

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Lafoensia pacari A. St.-Hil., Lythraceae, is used in Brazilian folk medicine to treat ulcer and gastritis; thus, it is important to conduct research so as to better understand its medicinal properties. The aim of this study was to assess the antisecretory and antiulcerogenic activities of lyophilized aqueous fraction and punicalagin isolated from leaves of L. pacari. Antisecretory gastric acid activity and antiulcerogenic activity were investigated by pyloric ligation-induced and indomethacin-induced gastric lesion models, respectively. Results show that the lyophilized aqueous fraction of L. pacari and punicalagin reduced the volume of gastric secretion, free acidity, and total acidity in mice 4 h after pyloric ligation, as well as the rate of gastric damage following the indomethacin administration model. Reduction percentages varied according to the dose of each treatment and showed statistical difference. This finding indicates that the lyophilized aqueous fraction of L. pacari and punicalagin exert an antiulcerogenic effect due to their acid antisecretory activity.

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“…However, several studies reported that various extracts from species of the family Lythraceae, such as Cuphea aequipetala (Avila et al, 2004), L. inermis (Borade et al, 2011) and Cuphea carthagensis (Elgindi et al, 2011), showed cytotoxicity. Galdino et al (2010) demonstrated the presence of saponins in fractions of L. pacari stem bark. Podolak et al (2010) reported that saponins possess cytotoxic activity, stimulate the apoptotic process, and cause cell cycle arrest and cytoskeleton disintegration in tumor cells.…”

Section: Discussionmentioning

confidence: 95%

“…Studies on the toxicity of L. pacari demonstrated that the stem bark extract from this plant was not toxic at a dose of 5 g/kg using a toxicity test in Wistar rats (Lago, 2004;Galdino et al, 2010) and in humans at the dose of 1.0 g/kg in a clinical trial for the eradication of Helicobacter pylori (da Mota et al, 2006). However, several studies reported that various extracts from species of the family Lythraceae, such as Cuphea aequipetala (Avila et al, 2004), L. inermis (Borade et al, 2011) and Cuphea carthagensis (Elgindi et al, 2011), showed cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice

Fd¹,

Silva²,

Sampaio³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Lafoensia pacari (Lythraceae), popularly known in Brazil as "pacari", is a small tree native to the Cerrado that is used in folk medicine to treat cancer and as an anti-inflammatory and cicatrizing agent. We evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of an ethanol extract of L. pacari stem bark (EESB) using the Ames test and the mouse bone marrow micronucleus test. In the Ames test, EESB did not significantly increase the number of His + revertants in Salmonella typhimurium tester strains TA98 and TA100 at all doses, demonstrating lack of mutagenicity. Only the highest dose of EESB significantly increased the micronucleated polychromatic erythrocyte frequency in the micronucleus test, indicating mild genotoxicity. EESB produced a mutagenic index lower than the negative control in the Ames test. In the micronucleus test, at all doses, EESB caused a significant decrease in the polychromatic/normochromatic erythrocyte ratio (PCE/NCE) at 24 h compared with the negative control. EESB co-administered together with the respective positive control caused a significant decrease in the number of His + revertant colonies in the Ames test and in the frequency of micronucleated polychromatic erythrocytes in the micronucleus test, demonstrating a DNA protector effect. EESB co-administered with mitomycin C significantly increased the PCE/NCE ratio at all doses, showing an anticytotoxic effect. We conclude that EESB has antigenotoxic and anticytotoxic properties.

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Central activities of hydroalcoholic extract from Lafoensia pacari A. St.-Hil. stem bark

Cited by 8 publications

References 27 publications

Citrus limon (L.) Burm f. Essential Oil Has Anxiolytic and Sedative Properties by Modulating GABAA-Receptors

Citrus limon (L.) Burm f. Essential Oil Has Anxiolytic and Sedative Properties by Modulating GABAA-Receptors

Gastroprotective activity of punicalagin and Lafoensia pacari in mice

Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice

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