The importance of animal studies in Exercise Science

Abstract

-The validity and relevance of research with animals for the development of knowledge in Exercise Science have for long been discussed. Given the complexity of the biological systems, the use of animal models offers a significant contribution to uncover new findings about acute and chronic effects of exercise, particularly when these studies in humans have limitations and ethical implications. There have been notable findings using experimental animals either in basic sciences or in clinical studies involving physiology, pharmacology, genetic, biochemistry, urology, endocrinology and cancer. This article presents a brief review of scientific research using animal models with a focus on exercise training as an effective tool for the prophylaxis and treatment of different pathological processes, which are the basis of many concepts taught and used in undergraduate courses and graduate programs, as well as in new researches showed in scientific conference meetings in numerous areas of science.

Considerations for Exercise Prescription in Patients With Bone Metastases: A Comprehensive Narrative Review

“…Given the complexity of biological systems, the use of animal models has provided a significant understanding of the various adaptive mechanisms undergoing acute and chronic physical exercise [94]. Studies examining the effect of exercise training in animal models with metastatic bone disease were also included.…”

Effects of Juçara (Euterpe edulis Martius) on Health: An Overview of Clinical and Experimental Studies and Call for Action

“…Experimental Design In short, the available studies are predominantly experimental tests using rats or mice performed when the investigation of human beings is not feasible. Results from these studies are incipient, although several health conditions have been evaluated because experimental studies are limited regarding the extrapolation of results to human beings due to differences between species, metabolic mechanisms, and dosages that may invalidate generalizations [36,37]. Most clinical studies analyzed herein have robust designs, such as crossover or placebo-controlled single or double-blind designs.…”

Protocolos De Treinamento Físico Em Modelos Experimentais Usados Na Pesquisa Em Educação Física

“…Dessa forma, protocolos de treinamento físico em modelos experimentais foram desenvolvidos ao longo dos anos, a fim de possibilitar a compreensão de fenômenos inviáveis de serem estudados em humanos. Além disso, o estudo com modelos experimentais possibilita o controle de fatores ambientais, psicológicos e emocionais, que são limitações de grande complexidade na pesquisa com seres humanos (De Angelis et al, 2017).…”