Considerations for Exercise Prescription in Patients With Bone Metastases: A Comprehensive Narrative Review

Sheill, Gráinne; Guinan, Emer; Peat, Nicola; Hussey, Juliette

doi:10.1016/j.pmrj.2018.02.006

Cited by 73 publications

(66 citation statements)

References 112 publications

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“…The findings of this narrative analysis strongly suggest that a standardized exercise guideline of a total 150-minute moderate-intensity exercise on a weekly basis might not be readily achievable for patients with late-stage or metastatic lung cancer [11,37,55]. In fact, exercise guidelines, such as resistance, balance, and stretching exercise programs, were suggested to be customized for fitting cancer patients with metastatic disease or severely weakened physical conditions [12,23,[56][57][58][59][60].…”

Section: Plos Onementioning

confidence: 96%

Exercise experiences in patients with metastatic lung cancer: A qualitative approach

et al. 2020

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Background Patients with metastatic lung cancer can have severe cancer-related symptoms and treatment-induced side effects. Exercise is beneficial for patients with metastatic lung cancer; however, little information is available on guiding patients how to perform exercise during hospitalization. The purpose of this qualitative study was to understand exercise experiences in patients with metastatic lung cancer. Methods Patients with metastatic lung cancer (n = 24) participated in face-to-face in-depth interviews at an inpatient ward of a medical center in central Taiwan. Interview transcripts were evaluated using narrative analysis to extract and validate themes. Results Three primary themes were identified: (1) modifying exercise to maximize physical functions; (2) living with symptoms and frustration, but still exercising; and (3) doing exercise to sustain hopes, inner power, and life. Secondary findings included: (1) adopting walking as their main form of exercise because of its convenience; and (2) among patients with severe symptoms, adjusting exercise towards shorter time durations and shorter distances, slower speeds, and higher frequencies. Conclusions The study found physically active lung cancer patients, although with metastatic condition, adjusted their exercise activities to balance disease and treatment-induced deteriorations and boost themselves to feel hope and fight for cancer. However, the results may not be

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Section: Plos Onementioning

confidence: 96%

Exercise experiences in patients with metastatic lung cancer: A qualitative approach

et al. 2020

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“…As the average life expectancy in such patients increases, so does the incidence of BM. 1 Patients with BM have a reasonable prognosis and should be physically active. 2 Nevertheless, several physicians advise against eccentric strengthening exercises of the affected joints/segments, given the empirical proof of increased risk of fracture.…”

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confidence: 99%

“…A recent comprehensive narrative review did not find a high fracture incidence with increased mobility. 1 Cancer patients with BM display a positive response to rehabilitation. Gaps in providing cancer rehabilitation services to those who would benefit, namely patients in PC, equates to unnecessary physical and psychological suffering.…”

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confidence: 99%

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Physical Rehabilitation in Cancer Patients with Bone Metastasis: Added Value or Inconvenience?

Serranito¹,

Reis-Pina

2020

Acta Med Port

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“…For instance, voluntary wheel running decreases incidence and progression of tumors, including skin, liver, and lung cancers in preclinical studies (15). Collectively, physical activity could be a unique form of adjutant therapies for patients with breast cancer and bone metastases (16). There are varying types of mechanical loading, which, in part, mimics physical activity.…”

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confidence: 99%

Ankle loading ameliorates bone loss from breast cancer–associated bone metastasis

et al. 2019

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Breast cancer is a serious health problem that preferentially metastasizes to bone. We have previously shown that bone loss can be prevented by mechanical loading, but the efficacy of ankle loading for metastasis‐linked bone loss has not been investigated. This study showed that body weight was decreased after inoculation of tumor cells, but ankle loading restored a rapid weight loss. The nonloading group exhibited a decrease in bone volume/tissue volume (BV/TV), trabecular thickness, and trabecular number (all P < 0.01) as well as an increase in trabecular separation (P < 0.001). However, ankle loading improved those changes (all P < 0.05). Furthermore, although the nonloading group increased the tumor bearing as well as expression of IL‐8 and matrix metalloproteinase 9, ankle loading decreased them. Induction of tumor in the bone elevated the osteoclast number (P < 0.05) as well as the levels of nuclear factor of activated T‐cells cytoplasmic 1, NF‐κB ligand, cathepsin K, and serum tartrate‐resistant acid phosphatase type 5b, but ankle loading reduced osteoclast activity and those levels (all P < 0.05). Tumor bearing was positively correlated with the osteoclast number (P < 0.01) and negatively correlated with BV/TV and the osteoblast number (both P < 0.01). Collectively, these findings demonstrate that ankle loading suppresses tumor growth and osteolysis by inhibiting bone resorption and enhancing bone formation.—Yang, S., Liu, H., Zhu, L., Li, X., Liu, D., Song, X., Yokota, H., Zhang, P. Ankle loading ameliorates bone loss from breast cancer–associated bone metastasis. FASEB J. 33, 10742–10752 (2019). http://www.fasebj.org

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Considerations for Exercise Prescription in Patients With Bone Metastases: A Comprehensive Narrative Review

Abstract: NA.

Cited by 73 publications

References 112 publications

Exercise experiences in patients with metastatic lung cancer: A qualitative approach

Exercise experiences in patients with metastatic lung cancer: A qualitative approach

Physical Rehabilitation in Cancer Patients with Bone Metastasis: Added Value or Inconvenience?

Ankle loading ameliorates bone loss from breast cancer–associated bone metastasis

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