Factors associated with bone mineral density in adults: a cross-sectional population-based study

Segheto, Kátia Josiany; Juvanhol, Leidjaira Lopes; Carvalho, Cristiane Junqueira de; Silva, Danielle Cristina Guimarães da; Kakehasi, Adriana Maria; Longo, Giana Zarbato

doi:10.1590/s1980-220x2018039903572

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…Excess body weight can cause metabolic changes in the form of insulin resistance and excessive production of androgen and estrogen hormones thereby reducing osteoblast action. Besides that, overproduction of adipokines or leptin levels due to high fat consumption may contribute to gained calcium absorption [35]. However, excessive subcutaneous fat and visceral fat can increase systemic inflammation which can trigger bone loss, besides that it is associated with increased levels of proinflammatory cytokines such as TNF and IL-6 which can promote bone resorption and increase the risk of osteoporosis [26].…”

Section: Discussionmentioning

confidence: 99%

Effect of Nutrient Intake, Nutritional Status, Physical Activity and Sunlight Exposure on Bone Mineral Density in Women: A Systematic Review

Firdawati¹,

Angraini²,

Indriani³

2023

ijcsrr

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Osteoporosis is a condition or disease that can cause bones to become brittle and break easily. The risk of osteoporosis in women is greater than in men, which is four times greater. Bone mineral density (BMD) or bone density is the total mineral present in bone. Measurement of BMD is important to show the degree of bone mineralization associated with osteoporosis. There are factors associated with reduced bone density. Thus, this systematic review aimed to analyze several factors related to BMD in women including nutrient intake, nutritional status, physical activity, and sunlight exposure. Studies in this systematic review were gathered by the (PRISMA) guidelines and identified through PubMed, Google Scholar, and ScienceDirect databases from 2017 until 2022. A total of 17 articles passed the eligibility and were analyzed in this systematic review. Studies found the effect of nutrient intake, BMI, physical activity, and sunlight exposure on BMD in women from different age groups. So it is necessary to make eating habits with good nutritional intake and have a lifestyle that routinely carries out sufficient physical activity and gets sufficient sunlight to improve and maintain bone health until old age.

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Section: Discussionmentioning

confidence: 99%

Effect of Nutrient Intake, Nutritional Status, Physical Activity and Sunlight Exposure on Bone Mineral Density in Women: A Systematic Review

Firdawati¹,

Angraini²,

Indriani³

2023

ijcsrr

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“…The prevalence of wrist fractures was higher in men than in women when the first wrist fracture occurred before the age of 60, which was supported by previous epidemiological studies of wrist fractures in which young men were more likely to have wrist fractures than young women ( 34 , 35 ). However, as women age, especially after menopause, they tend to lose more bone mass than men, which makes them more likely to suffer from wrist fractures ( 36 , 37 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence, Characteristics, and Associated Risk Factors of Wrist Fractures in Americans Above 50: The Cross-Sectional NHANES Study

Nie³

2022

Front. Endocrinol.

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SummaryBy analyzing data from NHANES, we aimed to evaluate the prevalence, characteristics, and associated factors of wrist fractures in Americans aged 50 and above.IntroductionWrist fractures, whose prevalence increases with age, are one of the most common fractures in the United States. However, epidemiological studies on the prevalence of wrist fractures of certain ages were limited.MethodsThe data of Americans aged 50 or above from 2013–2014 and 2017–2018 in NHANES were extracted and analyzed.ResultsThe prevalence of wrist fractures among Americans whose age was 50 or above was 12%, which was similar between men and women (men 12.8% vs. women 11.4%, p = 0.267). Among those who had experienced their first wrist fracture, 17.8% of the population experienced a second wrist fracture. The top two causes of the first wrist fracture were a fall from a standing height (56%) or a hard fall (34.8%). The prevalence of wrist fractures was higher in men than in women (13.7% versus 8.7%, p = 0.023) aged < 60, but higher in women than in men aged ≥ 60 (11.8% versus 14.3%, p = 0.007). Multivariate analysis showed that obesity, frequent drinking, current smoking, high serum phosphate level, non-Hispanic white women, and osteoporosis were independently associated with wrist fractures. Stratified by race, osteoporosis, frequent drinking, and high serum phosphate level were risk factors for wrist fractures in all races. As for Mexican Americans, non-Hispanic whites, and other races including multi-racial, current smoking was a risk factor of wrist factures. Furthermore, obesity was positively associated with wrist fractures in Mexican Americans, other Hispanics, and non-Hispanic whites.ConclusionThe prevalence of wrist fractures in Americans aged 50 and above was 12%. Falling from a standing height was the main cause of the first wrist fracture. Frequent drinking, current smoker, high serum phosphate level, osteoporosis, obesity, and non-Hispanic women were more likely to experience wrist fractures.

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“…12,13 Numerous studies have shown that using bone microarchitecture to assess trabecular bone score (TBS), in combination with an assessment of BMD and clinical risk factors, increases the prediction of fracture risk. [14][15][16] The use of TBS for assessing bone structure among patients with diseases that show significant effects on bone microarchitecture, including haemophilia, may be particularly valuable. 16 Haemophilic patients are predisposed to low bone density because of low levels of physical activity, reduced vitamin D levels, and blood-borne viral infections.…”

Section: Introductionmentioning

confidence: 99%

“…Although low bone mass, along with age, remains the most important risk factor for osteoporotic fractures, BMD alone is an inadequate parameter for assessing fracture risk, since bone strength, in addition to bone mass, is influenced by other factors, such as bone geometry (e.g., elongated femoral neck axis), trabecular bone microstructure, microdamage, bone mineralization, and bone turnover 12,13 . Numerous studies have shown that using bone microarchitecture to assess trabecular bone score (TBS), in combination with an assessment of BMD and clinical risk factors, increases the prediction of fracture risk 14–16 . The use of TBS for assessing bone structure among patients with diseases that show significant effects on bone microarchitecture, including haemophilia, may be particularly valuable 16 .…”

Section: Introductionmentioning

confidence: 99%

Association of bone mineral density and potential risk factors for osteoporosis in patients with severe haemophilia A

Biernat,

Jędrzejuk,

Urbaniak‐Kujda

et al. 2023

Haemophilia

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IntroductionIn people with haemophilia (PWH), recurrent episodes of bleeding lead to joint deterioration and bone resorption. To date, the effects of various other factors on bone mineral density (BMD) reduction have found conflicting results.AimThe aim of this study was to analyse the relationships between BMD, bone mineral content (BMC), and trabecular bone score (TBS) parameters based on the dual X‐ray absorptiometry method (DXA) and potential risk factors for osteoporosis in patients with severe haemophilia A.MethodsFifty‐five men with severe haemophilia A, aged 18–68 years, and 59 healthy volunteer men were enrolled in this study. Densitometric‐derived lumbar spine and femoral neck BMD, BMC, and TBS were measured. Blood analyses were performed for morphology parameters, liver and kidney function parameters, and viral status. Serum levels of oestradiol (E2), testosterone (T), dehydroepiandrosterone sulphate (DHEA‐S), parathormone, and vitamin D were measured.ResultsPatients showed significantly lower BMD compared to controls (p < .003). The result below the expected range for age was nearly double (6.82% vs. 3.92%) in PWH under 50 years old compared to controls. Haemophilic patients also exhibited significantly higher vitamin D3 deficiency (p < .0001), which was strongly associated with low TBS. Additionally, low body mass index and high neutrophil/lymphocyte ratio were correlated with low BMC and BMD.ConclusionsThis study confirms the prevalence of low BMD and BMC in patients with haemophilia in Poland. Factors that contribute to low BMD are primarily vitamin D deficiency, low BMI, high neutrophil/lymphocyte ratio, and low testosterone/oestradiol ratio.

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Factors associated with bone mineral density in adults: a cross-sectional population-based study

Cited by 7 publications

References 23 publications

Effect of Nutrient Intake, Nutritional Status, Physical Activity and Sunlight Exposure on Bone Mineral Density in Women: A Systematic Review

Effect of Nutrient Intake, Nutritional Status, Physical Activity and Sunlight Exposure on Bone Mineral Density in Women: A Systematic Review

Prevalence, Characteristics, and Associated Risk Factors of Wrist Fractures in Americans Above 50: The Cross-Sectional NHANES Study

Association of bone mineral density and potential risk factors for osteoporosis in patients with severe haemophilia A

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