Infecção oral pelo HPV em mulheres com lesão escamosa de colo uterino no sistema prisional da cidade de São Paulo, Brasil

Abstract

Carci noma of the head and neck is the 6 th cause of death by cancer in the world. In recent decades the human papillomavirus (HPV) has been implicated in the etiology of this disease Objective: To characterize the types of HPV detected in the oral mucosa in women with cytological abnormalities suggesting intraepithelial squamous lesions in the uterine cervix.Methods: four-hundred-nine cervical-vaginal and oral pap-smears of women interned in a Female Prison in São Paulo were examined. The relationship between cervical and oral lesion was analyzed by PCR/RFLP and DNA sequencing.Results: Of 27 (6.67%) specimens showing cervical cytological abnormalities suggesting LSIL and HSIL, 22 (81.48%) had oncogenic high-risk HPV infection, of which HPV 59 was the most prevalent. Three (11.1%) samples showed cytological changes suggesting mild dysplasia in the oral cavity. Conclusion:Our study suggests an association between carcinoma of the oral cavity and HPV infection, regardless of the virus type. Braz J Otorhinolaryngol. 2012;78(2):66-72. ORIGINAL ARTICLE BJORL

Prevalence of human papillomavirus (HPV) in Brazil: A systematic review and meta-analysis

“…There was a high heterogeneity in HPV oral prevalence among the studies in Brazil, ranging from zero to 96%. The two studies with the highest oral HPV prevalence, around 80%, investigated the presence of oral HPV DNA in women with diagnosis of genital HPV [141,146]. In terms of public health policy, our results suggest that while some efforts could be targeted towards regions and populations with higher HPV prevalence, broad approaches [171] seem appropriate, as illustrated by the fact that the prevalence of HPV is high even in low-risk populations and that it differs only slightly across regions.…”

Atenção à saúde de indivíduos privados de liberdade no sistema prisional brasileiro: uma revisão integrativa

“…Para Zonta et al 37 , a atividade sexual também possui ligação direta com a proliferação do papilomavírus humano (HPV), sendo o contato íntimo entre mucosas a principal via, não esquecendo que a transmissão vertical ocorre igualmente. Adicionalmente, Anjos et al 33 afirmaram serem a iniciação precoce à vida sexual e a alta rotatividade de parceiros sexuais fatores que aumentam as chances para o desenvolvimento das ISTs e do câncer do colo do útero.…”