Qual a relevância dos sinais e sintomas no prognóstico de pacientes com hérnia de disco lombar?

Falavigna, Asdrúbal; Neto, Orlando Righesso; Bossardi, Julia Bertholdo; Hoesker, Thiago; Gasperin, Paula Caprara; Silva, Pedro Guarise de; Teles, Alisson Roberto

doi:10.1590/s1808-18512010000200016

Cited by 2 publications

(3 citation statements)

References 52 publications

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“…7,10,13 In general, it is agreed that the Lasègue sign is a highly sensitive and specific sign for surgically proven disk protrusion and that its persistence in the postoperative period correlates with an unfavorable surgical outcome. 18,27 Despite these findings, there is still doubt concerning the prognostic importance of this sign in the preoperative period.…”

Section: Totalmentioning

confidence: 99%

“…12 Prognostic factors such as age, gender, duration of symptoms, smoking, level of operation and type of work appear to have a predictive value in the short-term results of LDH surgery. 9,[11][12][13][14][15][16][17] One of the clinical signs that have been studied as a predictor of outcome after lumbar disc surgery is the Lasègue test, also known as the straight leg raising test (SLR). 10,14 The Lasègue sign is frequently observed in patients with LDH.…”

Section: Introductionmentioning

confidence: 99%

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Is the lasègue sign a predictor of outcome in lumbar disc herniation surgery?

Falavigna

Righesso²,

Teles

et al. 2013

Coluna/Columna

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Objective: Evaluate the predictive value of the Lasègue sign on self-reported quality of life measures (HRQoL) in patients who undergo microdiscectomy. Methods: 95 patients with clinical and radiological diagnosis of LDH who underwent microdiscectomy were included. The patients were assessed by a neurological examination and answered validated instruments to assess pain, disability, quality of life, and mood disorder in the preoperative period, and 1, 6 and 12 months after surgery. Results: Preoperative Lasègue sign was identified in 56.8% (n=54/95) of the cases. There was no difference between the groups in the preoperative period regarding HRQoL. At one year follow-up no statistically significant difference in HRQoL was observed in the Lasègue group. The discrimination capacity of the preoperative Lasègue sign to determinate variations in HRQoL outcomes one year postoperatively was low. Conclusion: Lasègue sign is not a good predictor of outcome after microdiscectomy for LDH.Keywords: Intervertebral disc displacement; Quality of life; Prognosis; Spine/surgery. RESUMO Objetivo: Avaliar o valor preditivo do Sinal de Lasègue em medidas de qualidade de vida (HRQoL) em pacientes submetidos a microdiscectomia. Métodos: 95 pacientes com diagnóstico clínico e radiológico de HDL submetidos à microdiscectomia foram incluídos. Os pacientes foram avaliados por exame neurológico e responderam instrumentos validados para medir dor, incapacidade, qualidade de vida e transtornos do humor no período pré-operatório e 1, 6 e 12 meses após a cirurgia. Resultados: O sinal de Lasègue no pré-operatório foi identificado em 56,8% (n = 54/95) dos casos. Não houve diferença entre os grupos no pré-operatório em relação à HRQoL. Em um ano de pós-operatório não foi observada diferença estatística com relação à HRQoL no grupo com Lasègue. A capacidade de discriminação do Sinal de Lasègue pré-operatório para determinar variações na

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Section: Totalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is the lasègue sign a predictor of outcome in lumbar disc herniation surgery?

Falavigna

Righesso²,

Teles

et al. 2013

Coluna/Columna

Self Cite

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“…The disease is intimately related to intervertebral disc degeneration (Falavigna et al, 2010). However, the etiology of degenerative disc disease (DDD) is complex.…”

Section: Introductionmentioning

confidence: 99%

CASE-REPORT Association between an ACAN gene variable number tandem repeat polymorphism and lumbar disc herniation: a case control study

et al. 2016

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ABSTRACT. We investigated the association between an aggrecan gene (ACAN) polymorphism and lumbar disc herniation (LDH). This was a case-control study with quinquennial age and gender groups. The study comprised 119 men and women aged between 20 and 60 from Goiânia (Brazil). Of these, 39 were allocated to the case group (Ca) and 80 to the control group (Ct). We gathered sociodemographic and clinical data, and peripheral blood samples. DNA was isolated for genotyping the ACAN variable number tandem repeat (VNTR) via conventional polymerase chain reaction (PCR). Data were statistically analyzed using the chi-square test, multiple comparison analysis, the Student t-test, and odds ratios, with a level of significance set at 5% (P ≤ 0.05). The groups were homogenous in terms of sociodemographic, anthropometric, and life style variables. The allele score for the ACAN VNTR was significantly lower in volunteers with LDH; the A22 allele was significantly more prevalent in this same group; the Ca group presented greater frequency of short alleles A13-A25, whereas the Ct group presented a higher frequency of long alleles. However, this difference was not statistically significant. In both groups, the most common alleles were A28, A27, and A29, and the A26/A26 genotype was significantly more common in the Ca group. The results showed an association between short alleles and LDH among the investigated adults (Ca), corroborating the hypothesis that aggrecan with shorter repeat lengths can lead to a reduction in the physiological proteoglycan function of intervertebral disc hydration and, consequently, increased individual susceptibility to LDH.

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Qual a relevância dos sinais e sintomas no prognóstico de pacientes com hérnia de disco lombar?

Cited by 2 publications

References 52 publications

Is the lasègue sign a predictor of outcome in lumbar disc herniation surgery?

Is the lasègue sign a predictor of outcome in lumbar disc herniation surgery?

CASE-REPORT Association between an ACAN gene variable number tandem repeat polymorphism and lumbar disc herniation: a case control study

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