Lyme Disease Like Syndrome Associated Lymphocytoma: First Case Report in Brazil

Yoshinari, Natalino Hajime; Spolidorio, Mariana Granziera; Bonoldi, Virgínia Lúcia Nazário; Sotto, Miriam Nacagami

doi:10.1590/s1807-59322007000400020

Cited by 12 publications

(8 citation statements)

References 6 publications

(8 reference statements)

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“…In another study, using ELISA, anti- B. garinii antibodies were detected in patients with facial paralysis (Pirana et al , 2000). In the present study, the main risk variables found were the ticks attached to the body (p = 0.0056) and their presence indoors (p = 0.0164), which was consistent with other studies that have reported cases of Lyme disease in humans Yoshinari et al , 2007.…”

Section: Discussionsupporting

confidence: 93%

“…Different researchers have demonstrated the presence of antibodies and variations in clinical manifestations for the zoonoses in different regions of Brazil to understand the occurrence of Lyme disease(Yshikawa, 1996; Costa et al , 2001; Yoshinari et al , 2007; Naka et al , 2008). In the state of Parana, this was the first detection of antibodies against B. burgdorferi s.l.…”

Section: Discussionmentioning

confidence: 99%

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Zoonoses in humans from small rural properties in Jataizinho, Parana, Brazil

Gonçalves

Benitez

Lopes-Mori

et al. 2013

Braz. J. Microbiol.

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The aim of this study was to conduct a serological survey for Lyme diseases, brucellosis, leptospirosis and toxoplasmosis and identify the risk variables related to these zoonoses in humans living in the rural area of Jataizinho, state of Parana, Brazil. A total of 63 rural properties were surveyed. Additionally, 207 serum samples collected from these rural area inhabitants were tested for indirect immunofluorescence (IFI) and western blots (WB) were performed to detect Borrelia burgdorferi (sensu lato); a tamponated acidified antigen test (AAT) and 2-mercaptoethanol (2-ME) were used to detect antibodies of Brucella abortus; the microscopic agglutination test (MAT) was carried out to detect antibodies anti-Leptospira spp. and IFI was used to find antibodies of Toxoplasma gondii. Two of the samples (0.96%) were reactive for Lyme borreliosis, three (1.4%) for brucellosis, 25 (12.1%) for leptospirosis and 143 (69.1%) for toxoplasmosis. Although the town of Jataizinho has a human development index (IDH) that was considered to be average (0.733) in the state of Parana, the low social, economic and cultural conditions of the population from small rural properties have resulted in lack of basic information on animal health and direct or indirect contact with the various species of domestic animals, wildlife and ticks have probably contributed to the prevalence levels found. These results show the need for additional regional studies in order to determine the epidemiological characteristics of these diseases as well as their respective vectors and reservoirs so that effective prophylaxis can be administered in the human population.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Zoonoses in humans from small rural properties in Jataizinho, Parana, Brazil

Gonçalves

Benitez

Lopes-Mori

et al. 2013

Braz. J. Microbiol.

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“…The main clinical manifestations observed in BYS are described below: 1 -Cutaneous: migratory erythema ( Figure 3); secondary annular erythema, benign lymphocytoma, 25 atrophic chronic acrodermatitis, 15 paniculitis 15 and skin lesions similar to scleroderma at the initial tick bite place. 26 …”

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confidence: 99%

Doença de lyme-símile brasileira ou síndrome baggioyoshinari: zoonose exótica e emergente transmitida por carrapatos

Yoshinari¹,

Mantovani²,

Bonoldi³

et al. 2010

Rev. Assoc. Med. Bras.

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Lyme disease (LD) is a frequent zoonosis found in the Northern Hemisphere and is considered an infectious disease caused by spirochetes belonging to Borrelia burgdorferi sensu lato complex, transmitted by ticks of the Ixodes ricinus group. In 1992, the first cases resembling LD were described in Brazil in siblings who, after a tick bite episode, developed symptoms as erythema migrans, general flu-like symptoms and arthritis. Careful analysis of Brazilian LD-like illness casuistry showed that epidemiological, clinical and laboratorial features in the country were very different from those exhibited by North American and Eurasian LD patients. Human blood-suckers Ixodes ricinus complex ticks were absent at risk areas; the disease is recurrent in the country; Borrelia burgdorferi was never isolated in Brazil and specific serologic tests have shown little positivity with inconsistent results. Furthermore, peripheral blood analysis of patients on electron microscopy exhibited structures resembling Mycoplasma spp, Chlamydia spp and spirochete-like microorganisms. In fact, they were assumed to be latent forms of spirochetes (L form or cell wall deficient bacteria) adapted to survive at inhospitable conditions in vertebrate and invertebrate hosts. For these reasons, the Brazilian zoonosis was named Baggio-Yoshinari Syndrome (BYS) and defined as: ¨Exotic and emerging Brazilian infectious disease, transmitted by ticks not belonging to the Ixodes ricinus complex, caused by latent spirochetes with atypical morphology, which originates LD-like symptoms, except for occurrence of relapsing episodes and auto-immune disorders¨. Research conducted at the laboratory of Investigations in Rheumatology

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“…Because of differences in the clinical syndrome and vectors present in the region, LD in Brazil is also known as LD-like syndrome or Baggio-Yoshinari syndrome (BYS) (MANTOVANI et al, 2007). Although several human cases have been described throughout the country (YOSHINARI et al, 2003(YOSHINARI et al, , 2007CARRANZA-TAMAYO et al, 2012;ROSA et al, 2014), Borrelia spp. have not yet been isolated or characterized from such cases and Borrelia infection in humans remains to be confirmed in Brazil (YOSHINARI et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Serosurvey of Borrelia in dogs, horses, and humans exposed to ticks in a rural settlement of southern Brazil

Nascimento

Vieira

et al. 2016

Rev. Bras. Parasitol. Vet.

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The aims of the present study were to serosurvey dogs, horses, and humans highly exposed to tick bites for anti-Borrelia burgdorferi s.l. antibodies, identify tick species present, and determine risk factors associated with seropositivity in a rural settlement of Paraná State, southern Brazil. Eighty-seven residents were sampled, along with their 83 dogs and 18 horses, and individual questionnaires were administered. Immunofluorescence antibody test (IFAT) was performed on serum samples and positive samples were subjected to western blot (WB) analysis. Anti-B. burgdorferi antibodies were found in 4/87 (4.6%) humans, 26/83 (31.3%) dogs, and 7/18 (38.9%) horses by IFAT, with 4/4 humans also positive by WB. Ticks identified were mostly from dogs and included 45/67 Rhipicephalus sanguineus, 21/67 Amblyomma ovale, and 1/67 A. cajennense sensu lato. All (34/34) horse ticks were identified as A. cajennense s.l.. No significant association was found when age, gender, or presence of ticks was correlated to seropositivity to Borrelia sp. In conclusion, although anti-Borrelia antibodies have been found in dogs, horses and their owners from the rural settlement, the lack of isolation, molecular characterization, absence of competent vectors and the low specificity of the commercial WB kit used herein may have impaired risk factor analysis.

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Lyme Disease Like Syndrome Associated Lymphocytoma: First Case Report in Brazil

Cited by 12 publications

References 6 publications

Zoonoses in humans from small rural properties in Jataizinho, Parana, Brazil

Zoonoses in humans from small rural properties in Jataizinho, Parana, Brazil

Doença de lyme-símile brasileira ou síndrome baggioyoshinari: zoonose exótica e emergente transmitida por carrapatos

Serosurvey of Borrelia in dogs, horses, and humans exposed to ticks in a rural settlement of southern Brazil

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