Eosinophilic pneumonia: remember topical drugs as a potential etiology

Dias, Olívia Meira; Nascimento, Éllen Caroline Toledo do; Chate, Rodrigo Caruso; Kairalla, Ronaldo Adib; Baldi, Bruno Guedes

doi:10.1590/s1806-37562018000000028

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…In the phase IIb trial for HY-01 there were single reports of application site dermatitis and pruritis with the 1% formulation and single reports of nausea, application site erythema and pruritis, hypersensitivity, headache, rosacea, and urticaria with the 3% formulation [130]. To our knowledge, only one study reported a serious adverse effect, eosinophilic pneumonia, caused by topical minocycline for treatment of acne [150].…”

Section: Safety Of Locally Administered Minocycline Using Topical For...mentioning

confidence: 98%

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

et al. 2021

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Resistance of Cutibacterium acnes to topical antibiotics historically used to treat acne (topical erythromycin and clindamycin and, more recently, topical azithromycin and clarithromycin) has been steadily increasing and new topical antibiotics are needed. Minocycline is a semisynthetic tetracycline-derived antibiotic currently used systemically to treat a wide range of infections caused by Gram-negative and Gram-positive bacteria. In addition to its antibiotic activity, minocycline possesses anti-inflammatory properties, such as the downregulation of proinflammatory cytokine production, suppression of neutrophil chemotaxis, activation of superoxide dismutase, and inhibition of phagocytosis, among others. These characteristics make minocycline a valuable agent for treatment of dermatological diseases such as acne vulgaris and papulopustular rosacea. However, more frequent or serious adverse effects have been observed upon the systemic administration of minocycline than with other tetracyclines. Examples of serious adverse effects include hypersensitivity syndrome reaction, drug-induced lupus, idiopathic intracranial hypertension, and other autoimmune syndromes that may cause death. Here, we review adverse effects and drug–drug interactions observed with oral administration of minocycline and contrast this with topical minocycline formulations recently approved or under development for effectively treating dermatological disorders with fewer adverse effects and less drug interaction.

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Section: Safety Of Locally Administered Minocycline Using Topical For...mentioning

confidence: 98%

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

et al. 2021

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“…Most cases received outpatient treatment or in hospital war bed, rarely ICU and ECMO support. [27][28][29] Community hookah use can cause the transmission of infection diseases including herpes simplex virus, Epstein-Barr, Helicobacter pylori, hepatitis B, various respiratory viruses, bacterial meningitis, periodontal conditions such as oral candida and tuberculosis. Most smokers do not routinely clean the hookah device, the warm , humid and nutrient-rich internal components can promote survival of pathogens outside of the host.…”

Section: Oralmentioning

confidence: 99%

The Hookah, an Emerging Form of Smoking, Systemic Effects and Harmful Effects of Its Use

Oliveira¹,

Assunção²,

Tavares³

et al. 2022

MRAJ

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Hookah originates from India and in the last years spread around the world. The culture and the mystique behind this device promoted the use among the young population. Despite the thought that is the new safe way to smoke tobacco, recent studies showed that it can be more harmful than the cigarette, becoming a public health problem. Hookah increases airway reactivity and inflammation, causing an inflammation in the respiratory and cardiovascular system. The inhaled smoke contains chemicals agents that are toxic to the lung. As known in the literature the inhaled substance can lead to an acute eosinophilic pneumonia with a pulmonary interstitial infiltrate on radiological image. The degree of pulmonary involvement is varied and may cause a serious condition, requiring hospital admission and intensive care support. The treatment consists of ceasing the hookah use and the use of systemic corticosteroids. One important damage to the health is the infection disease like the tuberculosis transmission, cause by sharing the devise. In the cardiovascular system, the alterations were increasing the cardiac frequency and blood pressure in addition to causing inflammation in the endothelium of the vessel. Long-term studies are needed to correlate the use of this device with the risk of developing cancer.

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Minocycline

2019

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Eosinophilic pneumonia: remember topical drugs as a potential etiology

Cited by 3 publications

References 11 publications

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

The Hookah, an Emerging Form of Smoking, Systemic Effects and Harmful Effects of Its Use

Minocycline

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