ObjectiveTo analyze the clinical, laboratory and evolution data of patients with severe
influenza A H1N1 pneumonia and compare the data with that of patients with severe
community-acquired bacterial pneumonia. MethodsCohort and retrospective study. All patients admitted to the intensive care unit
between May 2009 and December 2010 with a diagnosis of severe pneumonia caused by
the influenza A H1N1 virus were included in the study. Thirty patients with severe
community-acquired pneumonia admitted within the same period were used as a
control group. Severe community-acquired pneumonia was defined as the presence of
at least one major severity criteria (ventilator or vasopressor use) or two minor
criteria. ResultsThe data of 45 patients were evaluated. Of these patients, 15 were infected with
H1N1. When compared to the group with community-acquired pneumonia, patients from
the H1N1 group had significantly lower leukocyte counts on admission (6,728±4,070
versus 16,038±7,863; p<0.05) and lower C-reactive protein levels (Day 2:
15.1±8.1 versus 22.1±10.9 mg/dL; p<0.05). The PaO2/FiO2
ratio values were lower in the first week in patients with H1N1. Patients who did
not survive the H1N1 severe pneumonia had significantly higher levels of
C-reactive protein and higher serum creatinine levels compared with patients who
survived. The mortality rate was significantly higher in the H1N1 group than in
the control group (53% versus 20%; p=0.056, respectivelly). ConclusionDifferences in the leukocyte count, C-reactive protein concentrations and
oxygenation profiles may contribute to the diagnosis and prognosis of patients
with severe influenza A H1N1 virus-related pneumonia and community-acquired
pneumonia.