In addition to improving the performance of the cytological diagnosis of the high-grade squamous intraepithelial lesion, the proposed quality control strategy allows a reflection on the causes of incorrect or conflicting scrutiny.
ObjectiveTo analyze the clinical, laboratory and evolution data of patients with severe
influenza A H1N1 pneumonia and compare the data with that of patients with severe
community-acquired bacterial pneumonia. MethodsCohort and retrospective study. All patients admitted to the intensive care unit
between May 2009 and December 2010 with a diagnosis of severe pneumonia caused by
the influenza A H1N1 virus were included in the study. Thirty patients with severe
community-acquired pneumonia admitted within the same period were used as a
control group. Severe community-acquired pneumonia was defined as the presence of
at least one major severity criteria (ventilator or vasopressor use) or two minor
criteria. ResultsThe data of 45 patients were evaluated. Of these patients, 15 were infected with
H1N1. When compared to the group with community-acquired pneumonia, patients from
the H1N1 group had significantly lower leukocyte counts on admission (6,728±4,070
versus 16,038±7,863; p<0.05) and lower C-reactive protein levels (Day 2:
15.1±8.1 versus 22.1±10.9 mg/dL; p<0.05). The PaO2/FiO2
ratio values were lower in the first week in patients with H1N1. Patients who did
not survive the H1N1 severe pneumonia had significantly higher levels of
C-reactive protein and higher serum creatinine levels compared with patients who
survived. The mortality rate was significantly higher in the H1N1 group than in
the control group (53% versus 20%; p=0.056, respectivelly). ConclusionDifferences in the leukocyte count, C-reactive protein concentrations and
oxygenation profiles may contribute to the diagnosis and prognosis of patients
with severe influenza A H1N1 virus-related pneumonia and community-acquired
pneumonia.
The authors analyze the relation between gastrointestinal carcinogenesis and Chagas disease, based on detailed review of the literature. To this end, epidemiological, experimental and human material pathology description studies have been selected. The article discusses the possibility of protection being afforded by not fully known morphokinetic cellular, immune and neuroendocrine factors that would be secondary to plexus degeneration. Also aspects related to the parasite-host interaction from the viewpoint of epithelial modulation of colonic mucosa and its antitumor implications are presented. Finally, it exposes the pathophysiological mechanism of esophageal cancer development in patients with mega-organ. In conclusion, chagasic colopathy, especially the intrinsic neuronal damage, is a study model that can contribute to the understanding of colorectal carcinogenesis.
There are several risk factors associated with erectile dysfunction (ED) and so it is important to identify them to improve the therapeutic approach. The objective of this study was to evaluate the association between obesity and ED. In this prospective cross-sectional observational study, the IIEF questionnaire was used to evaluate erectile function. The total sample of 38 subjects was divided into two groups; 23 obese individuals (BMI ≥30) with a mean BMI of 46.07, and 15 non-obese subjects (BMI <30) with a mean BMI of 25.9. Some degree of ED was evidenced in 52.17% of the obese and in 6.6% of the non-obese subjects. Statistical significance was found between the two groups using logistic regression. Thus, obesity is a risk factor for ED.
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