Efeitos adversos causados pelo novo esquema de tratamento da tuberculose preconizado pelo Ministério da Saúde do Brasil

OBJECTIVE: To describe the rates of cure, treatment failure, and treatment abandonment obtained with the basic regimen recommended by the Brazilian National Ministry of Health-rifampin, isoniazid, pyrazinamide, and ethambutol for two months, followed by isoniazid and rifampin for four months-involving the use of fixed-dose combination tablets (self-administered treatment), as well as to describe adverse events and their potential impact on treatment outcomes. METHODS: This was a descriptive study based on prospective data obtained from the medical records of tuberculosis patients (≥ 18 years of age) treated with the basic regimen at either of two primary health care facilities in the greater metropolitan area of Goiânia, Brazil. RESULTS: The study sample comprised 40 tuberculosis patients. The rate of cure was 67.5%, the rate of treatment abandonment was 17.5%, and there were no cases of treatment failure. Of the 40 patients in the sample, 19 (47%) reported adverse reactions, which were mild and moderate, respectively, in 87% and 13% of the cases. It was not necessary to alter the regimen or discontinue the treatment in any of the cases evaluated. CONCLUSIONS: The rate of cure obtained with the self-administered, fixed-dose combination tablet form of the new basic regimen was similar to the historical rates of cure obtained with the previous basic regimen. The rate of treatment abandonment in our sample was much higher than that considered appropriate (up to 5%).

show abstract

“…Musculoskeletal adverse reactions were the most common (in 24.94%), followed by cutaneous adverse reactions (in 22.09%). ( 27 ) …”

Section: Discussionmentioning

confidence: 99%

Desfechos clínicos do tratamento de tuberculose utilizando o esquema básico recomendado pelo Ministério da Saúde do Brasil com comprimidos em dose fixa combinada na região metropolitana de Goiânia

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Regarding the physical area, individuals with TB have both their physical and emotional well-being affected, since they experience symptoms of discomfort, using medications that may cause adverse reactions during the entire period of treatment (14) .…”

Section: Discussionmentioning

confidence: 99%

Aids e tuberculose: a coinfecção vista pela perspectiva da qualidade de vida dos indivíduos

Neves¹,

Canini

Reis

et al. 2012

Rev. esc. enferm. USP

View full text Add to dashboard Cite

A coinfecção tuberculose (TB) e HIV afeta negativamente a vida dos indivíduos, tanto nos aspectos biológicos como nos psicossociais. Com o objetivo de descrever a qualidade de vida de indivíduos com coinfecção HIV/TB, foi realizado este estudo descritivo, de corte transversal, no município de Ribeirão Preto-SP. Foram entrevistados indivíduos soropositivos para o HIV, com e sem TB, por meio do instrumento WHOQOL-HIV bref. Participaram 115 indivíduos soropositivos para o HIV - 57 coinfectados e 58 não coinfectados; a maioria do sexo masculino, heterossexuais, faixa etária predominante de 40-49 anos, com os coinfectados apresentando baixas escolaridade e renda; na avaliação da qualidade de vida os coinfectados apresentaram resultados mais baixos em todos os domínios, com diferença importante no Físico, Psicológico, Nível de Independência e Relações Sociais. TB e HIV/aids são doenças estigmatizadas historicamente e a sobreposição das duas pode ter consequências graves na saúde física e psicossocial do indivíduo.

show abstract

“…These manifestations are commonly related to the intake of isoniazid, with peripheral neuropathy the most frequent complaint, requiring the daily oral supplementation of pyridoxine (50 mg), especially in elderly individuals, aimed at minimizing polyneuropathy 22 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological, clinical and evolutionary aspects of tuberculosis among elderly patients of a university hospital in Belém, Pará

Chaves

Carneiro

Santos

et al. 2017

Rev. bras. geriatr. gerontol.

View full text Add to dashboard Cite

Objective: To evaluate the epidemiological, clinical and evolutionary aspects of tuberculosis in elderly patients of a university hospital in Belém, Pará. Method: A cross-sectional study was conducted in a university hospital, where 82 records of cases of tuberculosis in elderly patients were analyzed. The data was analyzed by applying the G-test, assuming a level of α=0.05 (5%) and a value of p=0.05. Results: Most of the elderly patients were male (64.6%), aged 60-69 years, especially among men (64.2%). Most were new cases of tuberculosis (95.1%), with a pulmonary clinical form (75.6%), associated diseases (69.5%) and a length of stay exceeding 21 days. Fever (67.1%), dyspnea (64.6%), weight loss (61.0%), productive cough (59.8%), chest pain (51.2%) were the main signs and symptoms. Regarding treatment, there was a high percentage of adverse reactions (50%), predominantly gastrointestinal events (70.7%). Most patients were cured (59.8%), but mortality from tuberculosis was considered high (15.9%). In terms of the exposure variables and outcome, there was a statistically significant difference for the age group ( p=0.017), length of stay ( p=0.000) and adverse reactions ( p=0.018) only. Conclusion:The clinical presentation and therapeutic management of tuberculosis among the elderly has characteristics peculiar to this group, making it important to strengthen strategies that facilitate early identification of suspected cases of TB among elderly persons in the community, which should take place mainly through the primary care system.

show abstract

Efeitos adversos causados pelo novo esquema de tratamento da tuberculose preconizado pelo Ministério da Saúde do Brasil

Cited by 42 publications

References 12 publications

Desfechos clínicos do tratamento de tuberculose utilizando o esquema básico recomendado pelo Ministério da Saúde do Brasil com comprimidos em dose fixa combinada na região metropolitana de Goiânia

Desfechos clínicos do tratamento de tuberculose utilizando o esquema básico recomendado pelo Ministério da Saúde do Brasil com comprimidos em dose fixa combinada na região metropolitana de Goiânia

Aids e tuberculose: a coinfecção vista pela perspectiva da qualidade de vida dos indivíduos

Epidemiological, clinical and evolutionary aspects of tuberculosis among elderly patients of a university hospital in Belém, Pará

Contact Info

Product

Resources

About