Associação entre paracoccidioidomicose e tuberculose: realidade e erro diagnóstico

Júnior, Reynaldo Quagliato; Grangeia, Tiago De Araujo Guerra; Massucio, Reinaldo Alexandre de Carvalho; Capitani, Eduardo Mello De; Rezende, Sílvio de Moraes; Balthazar, Alípio Barbosa

doi:10.1590/s1806-37132007000300011

Cited by 41 publications

(18 citation statements)

References 8 publications

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“…Association with other diseases was noticed in 4 patients, and this is in accordance with other authors who recorded comorbidities such as pulmonary tuberculosis, lymph node tuberculosis, leprosy, Hodgkin's disease, lung carcinoma, sporotrichosis, chromoblastomycosis, cutaneous leishmaniasis, histoplasmosis, cryptococcosis, and others 1,19 .…”

Section: Discussionsupporting

confidence: 89%

Paracoccidioidomycosis in the state of Maranhão, Brazil: geographical and clinical aspects

Matos

Santos

Silva

et al. 2012

Rev. Soc. Bras. Med. Trop.

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.3% of cases proving to be important areas for study. The western region, with a prevalence of 10.8/100,000 inhabitants, has a significantly higher proportion of cases than the northern, southern, and eastern regions (p < 0.05). The occurrence was higher in men with 89.3% of cases, and the male-to-female ratio was 8.4:1. The majority of patients were older than 20 years, lived in rural areas, and had farming or soil management as main occupation (73.8%). At CREDIP, 29 cases were diagnosed, of which 26 (89.6%) had multifocal manifestations. Mucous tissues were involved more (75.8%) frequently, followed by lymph nodes, skin, and lungs with 65.5%, 39% and 37.9 %, respectively. The diagnosis was made by combining direct examination, culture, and histopathology. Conclusions: The study shows the geographical distribution and the epidemiological and clinical aspects of paracoccidioidomycosis, revealing the significance of the disease to the State of Maranhão.

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Section: Discussionsupporting

confidence: 89%

Paracoccidioidomycosis in the state of Maranhão, Brazil: geographical and clinical aspects

Matos

Santos

Silva

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…Epidemiological factors and immune response patterns can justify the presence of intestinal worm coinfection. The incidence of TB and PCM coinfection reported in the literature is about 5% to 19% [29,30], similar to the data detected in this study. However, pulmonary TB is mostly related to the chronic type of PCM.…”

Section: Discussionsupporting

confidence: 91%

Acute juvenile Paracoccidioidomycosis: A 9-year cohort study in the endemic area of Rio de Janeiro, Brazil

Macedo¹,

Almeida‐Paes²,

Freitas³

et al. 2017

PLoS Negl Trop Dis

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BackgroundParacoccidioidomycosis (PCM) is a systemic mycosis caused by pathogenic dimorphic fungi of the genus Paracoccidioides. It is the most important systemic mycosis in Latin America and the leading cause of hospitalizations and death among them in Brazil. Acute PCM is less frequent but relevant because vulnerable young patients are affected and the severity is usually higher than that of the chronic type.MethodsThe authors performed a retrospective cohort study from 2001 to 2009 including acute juvenile PCM patients from a reference center in Rio de Janeiro, Brazil. Clinical, epidemiological, diagnostic, therapeutic, and prognostic data were reported.ResultsTwenty-nine patients were included. The average age was 23 years old and the male to female ratio was 1:1.07. All cases were referred from 3 of 9 existing health areas in the state of Rio de Janeiro, predominantly from urban areas (96.5%). Lymph nodes were the most affected organs (100%), followed by the skin and the spleen (31% each). Twenty-eight patients completed treatment (median 25 months) and progressed to clinical and serological cure; 1 death occurred. Twenty-four patients completed 48-month median follow-up. Four patients abandoned follow-up after the end of treatment. The most frequent sequela was low adrenal reserve. Paracoccidioides brasiliensis S1 was identified by partial sequencing of the arf and gp43 genes from 4 patients who presented a viable fungal culture.ConclusionAcute juvenile PCM is a severe disease with a high rate of complications. There are few cohort clinical studies of acute PCM in the literature. More studies should be developed to promote improvement in patients’ healthcare.

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“…PCM-tuberculosis coinfection has been observed in 5.5% to 19% of patients with this mycosis 17,24,26 and constitutes an important public health issue, not only for the high prevalence of tuberculosis in Brazil, but also because they are involved in the differential diagnosis of many cases 16 .…”

Section: Discussionmentioning

confidence: 99%

Decreasing Prevalence of the Acute/Subacute Clinical Form of Paracoccidioidomycosis in Mato Grosso Do Sul State, Brazil

Fabris

Andrade

Santos

et al. 2014

Rev. Inst. Med. trop. S. Paulo

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With the objective to evaluate the behavior of paracoccidioidomycosis in the last three decades, clinical and epidemiological data of 595 patients admitted to clinical services of the Federal University of Mato Grosso do Sul from 1980 to 2009 were investigated. Gender, age distribution, clinical form, comorbidity with tuberculosis or AIDS, and mortality were compared by decades of clinical admission. It was shown that during the three decades there was a decrease in women percentage, and the same manner occurred a reduction in participants in the age group of 20 to 39 years. Moreover, the acute/subacute forms have been diminished in the period. These fluctuations are closely related and can be simultaneously analyzed. Increased AIDS co-infection prevalence from the first to the second decade was also revealed, coinciding with the appearance of the retroviral epidemic and stabilizing during the third decade. No change in the tuberculosis co-infection rate was observed (overall = 6.9%). It reinforces the importance of this co-morbidity. The overall mortality rate remained steady at 6.7%, not varying significantly from one decade to another. The persistent mortality rate calls attention to the importance of this neglected disease.

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Associação entre paracoccidioidomicose e tuberculose: realidade e erro diagnóstico

Cited by 41 publications

References 8 publications

Paracoccidioidomycosis in the state of Maranhão, Brazil: geographical and clinical aspects

Paracoccidioidomycosis in the state of Maranhão, Brazil: geographical and clinical aspects

Acute juvenile Paracoccidioidomycosis: A 9-year cohort study in the endemic area of Rio de Janeiro, Brazil

Decreasing Prevalence of the Acute/Subacute Clinical Form of Paracoccidioidomycosis in Mato Grosso Do Sul State, Brazil

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