Localização do carcinoma pulmonar em relação ao vício tabágico e ao sexo

Jamnik, Sérgio; Uehara, C; Silva, Vilmer Vieira da

doi:10.1590/s1806-37132006000600007

Cited by 11 publications

(3 citation statements)

References 8 publications

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“…The most common location of primary lung tumor was right upper lobe, 40 consistent with the location of lung nodules reported in our case. One study showed an upper lobe predominance of lung carcinoma in smokers, 43 compatible with the hypothesis that the upper lobe masses in our patient were related to smoking.…”

Section: Discussionsupporting

confidence: 92%

Metastatic Adenocarcinoma of Unknown Origin Presenting as Small Bowel Perforation

Alkabie

Bello

Martínez

et al. 2015

Journal of Investigative Medicine High Impact Case Reports

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Metastatic malignant tumors that originate from occult primaries are defined as “cancers of unknown origin.” We herein present the case of a 59-year-old man who presented with small bowel perforation secondary to metastatic adenocarcinoma of an unknown primary site. Imaging exhibited two pulmonary nodules, neither of which was dominant, along with mediastinal and retroperitoneal lymphadenopathy. Immunohistochemical profiling of the small bowel biopsy specimens revealed the tumor was most likely pulmonary in origin.

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Section: Discussionsupporting

confidence: 92%

Metastatic Adenocarcinoma of Unknown Origin Presenting as Small Bowel Perforation

Alkabie

Bello

Martínez

et al. 2015

Journal of Investigative Medicine High Impact Case Reports

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“…In our study, the most frequently affected pulmonary region was the right upper lobe, which is also implicated in smokers, given that carcinogens persist over longer periods in the upper parts of the lung [3,4]. Multiple brain metastases, however, were more often found in lower lobe tumors, most likely attributable to more intensive circulation.…”

Section: Discussionmentioning

confidence: 80%

Significance of Primary Tumor Location and Histology for Brain Metastasis Development and Peritumoral Brain Edema in Lung Cancer

et al. 2016

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Background: Brain metastasis of lung cancer adversely affects overall survival (OS) and quality of life, while peritumoral brain edema is responsible for life-threatening complications. Methods: We retrospectively analyzed the clinicopathological and cerebral radiological data of 575 consecutive lung cancer patients with brain metastases. Results: In adenocarcinoma and squamous cell carcinoma, peritumoral brain edema was more pronounced than in small-cell lung cancer (p < 0.001 and p < 0.001, respectively). There was a positive correlation between the size of metastasis and the thickness of peritumoral brain edema (p < 0.001). It was thicker in supratentorial tumors (p = 0.019), in younger patients (≤50 years) (p = 0.042), and in females (p = 0.016). The time to development of brain metastasis was shorter in central than in peripheral lung cancer (5.3 vs. 9.0 months, p = 0.035). Early brain metastasis was characteristic for adenocarcinomas. A total of 135 patients had brain only metastases (N0 disease) characterized by peripheral lung cancer predominance (p < 0.001) and a longer time to development of brain metastasis (9.2 vs. 4.4 months, p < 0.001). OS was longer in the brain only subgroup than in patients with N1-3 diseases (p < 0.001). Conclusions: The clinicopathological characteristics of lung cancer are related to the development and radiographic features of brain metastases. Our results might be helpful in selecting patients who might benefit from prophylactic cranial irradiation.

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“…Most lung cancers develop in the upper lobes. Propensity for lung cancer development in the lower lobes has been reported in lung cancers developing in nonsmokers, although the presence or absence of an underlying driver mutation was not included in the study[ 74 ]. It has also been suggested that lower lobe tumors may be associated with a worse prognosis, but the studies did not include NSCLC with targetable mutations[ 75 , 76 ].…”

Section: Primary Tumor Featuresmentioning

confidence: 99%

Role of imaging biomarkers in mutation-driven non-small cell lung cancer

Mendoza

Piotrowska

Lennerz

et al. 2020

WJCO

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Lung cancer remains the leading cause of cancer-related deaths worldwide. The treatment of non-small cell lung cancer (NSCLC), which accounts for a vast majority of lung cancers, has shifted to personalized, targeted therapy following discoveries of several targetable oncogenic mutations. Targeting of specific mutations has improved outcomes in many patients. This success has led to several target-specific agents replacing chemotherapy as first-line treatment in certain mutated NSCLC. Several researchers have reported that there may be imaging biomarkers that may be predictive of the presence of these mutations. These features, when present, have the potential in triaging patients into the most appropriate diagnostic and treatment algorithms. Distinct imaging features and patterns of metastases that have been associated with NSCLC with various targetable oncogenic mutations are presented in this review.

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Localização do carcinoma pulmonar em relação ao vício tabágico e ao sexo

Cited by 11 publications

References 8 publications

Metastatic Adenocarcinoma of Unknown Origin Presenting as Small Bowel Perforation

Metastatic Adenocarcinoma of Unknown Origin Presenting as Small Bowel Perforation

Significance of Primary Tumor Location and Histology for Brain Metastasis Development and Peritumoral Brain Edema in Lung Cancer

Role of imaging biomarkers in mutation-driven non-small cell lung cancer

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