Effect of maternal diabetes on female offspring

Abstract

Objective To evaluate the effect of maternal diabetes on the blood pressure and kidney function of female offspring, as well as if such changes exacerbate during pregnancy.MethodsDiabetes mellitus was induced in female rats with the administration of streptozotocin in a single dose, one week before mating. During pregnancy, blood pressure was measured through plethysmography. On the 20th day of pregnancy, the animals were placed for 24 hours in metabolic cages to obtain urine samples. After the animals were removed from the cages, blood samples were withdrawn. One month after pregnancy, new blood and urine sample were collected. Kidney function was evaluated through proteinuria, plasma urea, plasma creatinine, creatinine excretion rate, urinary flow, and creatinine clearance.Results The female offspring from diabetic mothers showed an increase in blood pressure, and a decrease in glomerular filtration rate in relation to the control group.Conclusion Hyperglycemia during pregnancy was capable of causing an increase in blood pressure and kidney dysfunction in the female offspring.

The effects of long-term diabetes on the haematological and uterine indicators and their association with neonatal nephrogenesis counter-protected by camel milk: A time dependent study

“…Chronic hyperglycaemic intrauterine conditions lead to the shrinkage of the different renal regions in foe-https://doi.org/10.17221/97/2019-VETMED tuses except for the medullary region (Table 3 and Figure 4). Although there are no contemporary studies present to compare these data, though Martins et al (2014) recorded defective renal functions in threemonth-old pups delivered from diabetic dams. This renal dysfunction may be linked to the defective nephrogenesis due to subnormal uterine environment during the prenatal period in the chronic diabetes.…”