Selenoproteins and renal programming in metabolic syndrome-exposed rat offspring

Ojeda, María Luisa; Nogales, Fátima; Serrano, A. Lesmes; Murillo, María Luisa Ojeda; Carreras, Olimpia

doi:10.1039/d0fo00264j

Cited by 3 publications

(7 citation statements)

References 55 publications

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“…These pups also present hyperaldosteronemia, together with an altered function of Na + /K + -ATPasa provoked by OS, which produces hypernatremia. All these events contribute to a hypertensive status in these pups, as was demonstrated one week later [ 141 ]. Similar results have also been observed in children with low birth weight [ 169 ].…”

Section: Selenium Mets Programmingmentioning

confidence: 77%

“…Female pups present hepatomegaly and extremely low insulin serum levels, indicating a greater metabolic disruption in these pups; in male pups, growth and development are affected to a greater degree. Both sexes presented albuminuria, hypernatremia, and hyperaldosteronemia, leading to a hypertensive status [ 141 , 142 ]. All these changes difficult the weaning process as it is expressed in Figure 4 .…”

Section: Selenium Mets Programmingmentioning

confidence: 99%

“…Vahter et al reported that Se deposits in kidneys are age-dependent and that these levels increase during the postnatal period [ 160 ]. In the MetS-programming model proposed, pups presented Se kidney repletion independently of their sex; and high tubular Se reabsorption, since these pups have lower Se relative clearance [ 141 ]. Therefore, the expressions of the selenoproteins analyzed were all increased (GPx1, GPx3, GPx4, and SelP).…”

Section: Selenium Mets Programmingmentioning

confidence: 99%

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The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications

2022

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Selenium (Se) is an essential trace element mainly known for its antioxidant, anti-inflammatory, and anti-apoptotic properties, as it is part of the catalytic center of 25 different selenoproteins. Some of them are related to insulin resistance (IR) and metabolic syndrome (MetS) generation, modulating reactive oxygen species (ROS), and the energetic sensor AMP-activated protein kinase (AMPK); they can also regulate the nuclear transcription factor kappa-B (NF-kB), leading to changes in inflammation production. Selenoproteins are also necessary for the correct synthesis of insulin and thyroid hormones. They are also involved in endocrine central regulation of appetite and energy homeostasis, affecting growth and development. MetS, a complex metabolic disorder, can appear during gestation and lactation in mothers, leading to energetic and metabolic changes in their offspring that, according to the metabolic programming theory, will produce cardiovascular and metabolic diseases later in life. However, there is a gap concerning Se tissue levels and selenoproteins’ implications in MetS generation, which is even greater during MetS programming. This narrative review also provides an overview of the existing evidence, based on experimental research from our laboratory, which strengthens the fact that maternal MetS leads to changes in Se tissue deposits and antioxidant selenoproteins’ expression in their offspring. These changes contribute to alterations in tissues’ oxidative damage, inflammation, energy balance, and tissue function, mainly in the heart. Se imbalance also could modulate appetite and endocrine energy balance, affecting pups’ growth and development. MetS pups present a profile similar to that of diabetes type 1, which also appeared when dams were exposed to low-Se dietary supply. Maternal Se supplementation should be taken into account if, during gestation and/or lactation periods, there are suspicions of endocrine energy imbalance in the offspring, such as MetS. It could be an interesting therapy to induce heart reprogramming. However, more studies are necessary.

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Section: Selenium Mets Programmingmentioning

confidence: 77%

Section: Selenium Mets Programmingmentioning

confidence: 99%

Section: Selenium Mets Programmingmentioning

confidence: 99%

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The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications

2022

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“…Therefore, OS are responsible for a number of inflammatory, apoptotic, metabolic and growth retardation effects in the offspring [ 11 , 12 , 13 ]. Specifically, OS affects gestational parameters, leads to intrauterine growth retardation (IUGR) and abnormal development of tissues, which is related to endocrine metabolic imbalance and disorders in pregnancy [ 14 , 15 , 16 , 17 , 18 , 19 ]. OS effects depend on the ROS generated and the antioxidants present, as well as on the type of cell or organ affected [ 20 ].…”

Section: Fetal Programming and Oxidative Stressmentioning

confidence: 99%

“…The trace element Se (Se34 79) is essential for maternal health and fetal development during pregnancy and breastfeeding. This is not only due to its effects on the oxidant/antioxidant balance, but also for its other functions related to the modulation of metabolism, endocrine and energy balance [ 7 , 16 , 19 ]. Therefore, it is also implicated in protein synthesis, regulation of the cell cycle, remodeling of the tissue structure and its functionality [ 18 , 45 ].…”

Section: Selenium During Preconception Gestation and Lactationmentioning

confidence: 99%

Fetal Programming Is Deeply Related to Maternal Selenium Status and Oxidative Balance; Experimental Offspring Health Repercussions

et al. 2021

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Nutrients consumed by mothers during pregnancy and lactation can exert permanent effects upon infant developing tissues, which could represent an important risk factor for diseases during adulthood. One of the important nutrients that contributes to regulating the cell cycle and tissue development and functionality is the trace element selenium (Se). Maternal Se requirements increase during gestation and lactation. Se performs its biological action by forming part of 25 selenoproteins, most of which have antioxidant properties, such as glutathione peroxidases (GPxs) and selenoprotein P (SELENOP). These are also related to endocrine regulation, appetite, growth and energy homeostasis. In experimental studies, it has been found that low dietary maternal Se supply leads to an important oxidative disruption in dams and in their progeny. This oxidative stress deeply affects gestational parameters, and leads to intrauterine growth retardation and abnormal development of tissues, which is related to endocrine metabolic imbalance. Childhood pathologies related to oxidative stress during pregnancy and/or lactation, leading to metabolic programing disorders like fetal alcohol spectrum disorders (FASD), have been associated with a low maternal Se status and intrauterine growth retardation. In this context, Se supplementation therapy to alcoholic dams avoids growth retardation, hepatic oxidation and improves gestational and breastfeeding parameters in FASD pups. This review is focused on the important role that Se plays during intrauterine and breastfeeding development, in order to highlight it as a marker and/or a nutritional strategy to avoid diverse fetal programming disorders related to oxidative stress.

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Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway

Zhao

Gao

Hogenkamp

et al. 2021

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Selenium (Se)-enriched proteins are an important dietary source of Se for humans; however, only a few Se-enriched proteins have been identified. In the present study, we tested for potential antioxidant activity by Se-enriched soy protein, both in vitro and in vivo. Se-enriched soy protein isolate (S-SPI) was shown to have a higher free radical scavenging ability compared to ordinary soy protein isolate (O-SPI). Furthermore, Caco-2 cell viability was improved by S-SPI at low doses, whereas O-SPI did not. In addition, S-SPI was shown to inhibit oxidative stress via modulation of the NRF2-HO1 signaling pathway, upregulating the expression of downstream antioxidant enzymes (GPx, SOD). To further study the antioxidant capacity of S-SPI, BALB/c female mice were given oral gavages with 0.8 mL of S-SPI or O-SPI (5 g/kg/d, 20 g/kg/d and 40 g/kg/d) or saline as control. Hepatic GPx and SOD activity increased with increasing S-SPI dosage, but not with O-SPI. Taken together, our results suggest that Se-enriched soy protein has a high antioxidant ability and may be used as a dietary supplement for people with oxidative dam-age-mediated diseases.

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Selenoproteins and renal programming in metabolic syndrome-exposed rat offspring

Abstract: Selenoprotein implication in oxidative stress-related renal programming alteration in MS pups.

Cited by 3 publications

References 55 publications

The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications

The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications

Fetal Programming Is Deeply Related to Maternal Selenium Status and Oxidative Balance; Experimental Offspring Health Repercussions

Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway

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