Propolis: a review of its anti-inflammatory and healing actions

Ramos, A. F. N.; Miranda, João Luiz de

doi:10.1590/s1678-91992007000400002

Cited by 126 publications

(103 citation statements)

References 32 publications

(15 reference statements)

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“…On the other hand, effects of RNSP on the oxidative mtDNA damages are to be elucidated in future studies. With the line of our previous observations that oxidative mtDNA damages, in turn, impair the respiratory chain, forming a vicious cycle to promote the ROS generation [2], propolis may prevent and reverse "microglia-aging" through its anti-oxidant property [76][77][78][79][80] (Figure 1). …”

Section: Preventing and Reversing "Microglia-aging" By Nature Materialssupporting

confidence: 58%

“…The chemical composition of propolis depends on the local floral at the site of collection [73][74][75]. In addition to the fact that propolis has anti-oxidative and anti-inflammatory effects [76][77][78], we recently provided the first evidence that propolis can significantly inhibit the secretion of IL-1β, TNF-α and IL-6 by microglia through inhibition of the activation of NF-κB signaling pathway [12]. Furthermore, propolis significantly inhibits oxidative mtDNA damages, which are responsible for the induction of excessive ROS and the subsequent activation of NF-κB signaling pathway.…”

Section: Preventing and Reversing "Microglia-aging" By Nature Materialsmentioning

confidence: 99%

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Preventing and Reversing “Microglia-Aging” by Nature Materials for Slow Brain-Aging

Wu¹,

Zhu²,

Wu³

et al. 2013

Journal of Neurological Disorders

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Section: Preventing and Reversing "Microglia-aging" By Nature Materialssupporting

confidence: 58%

Section: Preventing and Reversing "Microglia-aging" By Nature Materialsmentioning

confidence: 99%

Preventing and Reversing “Microglia-Aging” by Nature Materials for Slow Brain-Aging

Wu¹,

Zhu²,

Wu³

et al. 2013

Journal of Neurological Disorders

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“…In general, the composition of propolis is directly related to that of the bud exudates collected by the honeybees from various plants, and these bud exudates depend on many ecological factors [7][8][9]. Propolis exhibits some functional properties such as antibacterial, anti-inflammatory, antiviral, antioxidative, and analgesic activity and many others [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Assessment of heavy metals in propolis and soil from the Pelagonia region, Republic of Macedonia

Popov

Hristova

Presilski

et al. 2017

Maced. J. Chem. Chem. Eng.

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In this study, the contents of five representative heavy metals (Cr, Pb, Zn, Cd and Cu) were determined in soil and propolis samples from four locations in southwestern Macedonia using atomic absorption spectrometry. The aim was to pinpoint the key factors that influence the content of heavy metals in propolis and to establish whether there is a connection between the contents of heavy metals in soil and in propolis from the same location. Generally, at all of the locations, the relative concentrations of heavy metals in soil were found to decrease in the following order: Zn>Cr>Cu>Pb>Cd. The highest mean values for concentrations of heavy metals in these soils were found to be: 72. 03, 38.28, 26.64, 17.15 and 0.60 mg kg -1 for Zn, Cr, Cu, Pb and Cd, respectively, and they are all below the target values from the new Dutch list. The general trend of the heavy metal contents in propolis from the same four locations, in decreasing order, is: Pb>Cr>Zn>Cu≈Cd. Generally, the propolis samples from the highland locations (Orle and Rapeš) had lower overall contents of heavy metals than the lowland locations (Novaci and Makovo). All of the analyzed propolis samples meet the requirements of the Macedonian legislation and the international organizations for the maximum allowed levels for heavy metals. Attempts were made to find a correlation between the heavy metal contents in soil and propolis. According to our aim, the investigation presented herein offers one step towards a complete picture of ecological safety of the specific areas in the Republic of Macedonia. To do so, it is necessary to perform additional studies and to find appropriate biomonitoring methods. Further studies are needed to complete the picture and to determine the major pathways of incorporation of heavy metals in beehive products.Key words: heavy metals; soil; propolis; atomic absorption spectrometry; honeybee; biomarker ПРОЦЕНА НА ТЕШКИ МЕТАЛИ ВО ПРОПОЛИС И ВО ПОЧВА ОД ПЕЛАГОНИСКИОТ РЕГИОН, РЕПУБЛИКА МАКЕДОНИЈАВо оваа студија, со користење на атомска апсорпциона спектрометрија, беше одредена содржината на пет тешки метали (Cr, Pb, Zn, Cd и Cu) во примероци почва и прополис, од четири локации во југозападниот дел на Македонија. Целта беше да се посочат клучните фактори кои влијаат на содржината на тешките метали во почвата и во прополис од иста локација. Општо земено, на сите локации релативните концентрации на тешки метали во почва беа со следниот опаѓачки редослед: Zn>Cr>Cu>Pb>Cd. Највисоките средни вредности од концентрациите на тешки метали во овие почви изнесуваат: 72,03; 38,28; 26,64; 17,15;0,60 mg kg -1 за Zn, Cr, Cu, Pb и Cd, соодветно, и сите тие се под целните вредности претставени во Холандската листа. Општиот тренд на содржината на тешки метали во прополисот од истите четири локации, е со следниот B. Bogdanova Popov, V. Karapetkovska Hristova, S. Presilski,M. A. Shariati, S. Najman Maced. J. Chem. Chem. Eng. 36(1), 23-33 (2017) 24 опаѓачки редослед: Pb>Cr>Zn>Cu≈Cd. Генерално, примероците од прополис од планинските локации (Орле и Ра...

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“…In addition, propolis is known to be a health food that presents antibacterial, antioxidative, immunomodulatory, antifungal, antiviral, antiprotozoal, antiinflammatory and antitumor activities (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Bosio et al (13) Though the antibacterial activity of propolis essential oil from Paraná and Piauí states has been reported, the literature on the antimicrobial activity of this oil from Rio de Janeiro State is scarce (17,21).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and antibacterial activity of Brazilian propolis essential oil

Oliveira¹,

França²,

Kuster³

et al. 2010

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:The present study aimed at investigating the chemical composition of essential oil extracted from Brazilian propolis and the susceptibility of Staphylococcus aureus, Staphylococcus epidermides, Streptococcus pyogenes and Escherichia coli to this substance. The essential oil was obtained by steam distillation of propolis and examined by gas chromatography/mass spectrometry (GC/MS). In addition, the agar diffusion method using filter paper disks was employed. Antibacterial activity was measured as equivalent diameters of inhibition zones (in millimeters) after incubation at 37C for 24 hours. From the 26 identified constituents, β-caryophyllene (12.7%), acetophenone (12.3%) and β-farnesene (9.2%) were found to be major components. New components, namely linalool, methyl hydrocinnamate, ethyl hydrocinnamate, α-ylangene, γ-elemene and valencene, are reported for the first time to be present in propolis essential oil. This oil also exhibited antibacterial activity.

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Propolis: a review of its anti-inflammatory and healing actions

Cited by 126 publications

References 32 publications

Preventing and Reversing “Microglia-Aging” by Nature Materials for Slow Brain-Aging

Preventing and Reversing “Microglia-Aging” by Nature Materials for Slow Brain-Aging

Assessment of heavy metals in propolis and soil from the Pelagonia region, Republic of Macedonia

Chemical composition and antibacterial activity of Brazilian propolis essential oil

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