A quantitative and qualitative evaluation of reports of clinical trials published in six Brazilian dental journals indexed in the Scientific Electronic Library Online (SciELO)

Souza, Raphael Freitas de; Chaves, Carolina de Andrade Lima; Nasser, Mona; Fedorowicz, Zbys

doi:10.1590/s1678-77572010000200002

Cited by 4 publications

(7 citation statements)

References 14 publications

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“…It is difficult to conclude if the differences found were due to poor reporting or different methods/characteristics. Unfortunately, few studies have evaluated the quality of RCT in LAC and it is difficult to establish if deficiencies are due to incomplete report and/or to methodologically poor designs; to the best of our knowledge, this is the first study assessing the risk of bias related to funding source in the region [32], [33].…”

Section: Discussionmentioning

confidence: 99%

“…Also, few studies in the region have assessed the nature and quality of scientific investigations, particularly randomized controlled trials (RCTs) in the region [4], [5]. As a result, it is uncertain whether or not RCTs in LAC are conducted in a way that facilitates innovation, improves health outcomes, and produces socioeconomic benefits for all, especially for marginalized groups whose access to innovative products and services has historically been limited [6]–[9].…”

Section: Introductionmentioning

confidence: 99%

“…Although previous studies have assessed RCTs in countries located in different regions like Asia [10], [11], Europe [12], and Sub-Saharan Africa [13], few have assessed RCTs in LAC [4], [5]. The lack of knowledge about the characteristics of the studies including their quality and the source of funding are problematic for many reasons.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source

et al. 2013

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IntroductionFew studies have assessed the nature and quality of randomized controlled trials (RCTs) in Latin America and the Caribbean (LAC).Methods and FindingsThe aims of this systematic review are to evaluate the characteristics (including the risk of bias assessment) of RCT conducted in LAC according to funding source. A review of RCTs published in 2010 in which the author's affiliation was from LAC was performed in PubMed and LILACS. Two reviewers independently extracted data and assessed the risk of bias. The primary outcomes were risk of bias assessment and funding source. A total of 1,695 references were found in PubMed and LILACS databases, of which 526 were RCTs (N = 73.513 participants). English was the dominant publication language (93%) and most of the RCTs were published in non-LAC journals (84.2%). Only five of the 19 identified countries accounted for nearly 95% of all RCTs conducted in the region (Brazil 70.9%, Mexico 10.1%, Argentina 5.9%, Colombia 3.8%, and Chile 3.4%). Few RCTs covered priority areas related with Millennium Development Goals like maternal health (6.7%) or high priority infectious diseases (3.8%). Regarding children, 3.6% and 0.4% RCT evaluated nutrition and diarrhea interventions respectively but none pneumonia. As a comparison, aesthetic and sport related interventions account for 4.6% of all trials. A random sample of RCTs (n = 358) was assessed for funding source: exclusively public (33.8%); private (e.g. pharmaceutical company) (15.3%); other (e.g. mixed, NGO) (15.1%); no funding (35.8%). Overall assessments for risk of bias showed no statistically significant differences between RCTs and type of funding source. Statistically significant differences favoring private and others type of funding was found when assessing trial registration and conflict of interest reporting.ConclusionFindings of this study could be used to provide more direction for future research to facilitate innovation, improve health outcomes or address priority health problems.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source

et al. 2013

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“…, de Souza et al . , Higgins & Green ). Each parameter of trial methodological quality was graded as ‘adequate’, ‘inadequate’, ‘unclear’ or ‘not applicable’ (de Souza et al .…”

Section: Methodsmentioning

confidence: 99%

Failure of single‐unit restorations on root filled posterior teeth: a systematic review

et al. 2017

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Afrashtehfar KI, Ahmadi M, Emami E, Abi-Nader S, Tamimi F. Failure of single-unit restorations on root filled posterior teeth: a systematic review. International Endodontic Journal, 50, 951-966, 2017. This systematic review investigated the failure rate of conventional single-unit restorations in root filled posterior permanent teeth. Two reviewers independently applied eligibility criteria, extracted data and assessed the quality of the evidence of each included study according to the Cochrane Collaboration's procedures for randomized control trials (RCTs) and the STROBE criteria for observational studies. The MEDLINE (via Ovid), EMBASE (via Ovid), Cochrane Oral Health Group Trials Register and CENTRAL (via Cochrane Library) databases were searched electronically (January 1993 to week 1, February 2015). This was complemented by an additional hand search of selected journals and the references of relevant studies. Clinical studies published on root filled single-unit restorative treatments with a mean follow-up period of at least 3 years were selected. The outcome measured was clinical or radiological failure. Overall, the four RCTs and the single observational study included were of low and high quality, respectively. Therefore, a meta-analysis was not possible. The pooled mean failure rates were reported according to the type of treatment and remaining coronal tooth structure. The current evidence suggested that the failure rates of the treatments may depend on the amount of remaining tooth structure and type of treatment. Postretained crowns were associated with the most favourable outcome in teeth with one to two remaining coronal tooth wall(s), whereas post-free crowns were superior when greater tooth structure was available. Restorations in teeth without ferrules had such a high rate of failure that other treatment options should be considered.

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“…; de Souza et al. ; Higgins & Green ). Two authors (ABR and RFS) performed this assessment and compared their results.…”

Section: Methodsmentioning

confidence: 99%

Focusing on outcomes and methods in removable prosthodontics trials: a systematic review

Souza

Ahmadi

Ribeiro

et al. 2013

Clinical Oral Implants Res

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A quantitative and qualitative evaluation of reports of clinical trials published in six Brazilian dental journals indexed in the Scientific Electronic Library Online (SciELO)

Cited by 4 publications

References 14 publications

Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source

Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source

Failure of single‐unit restorations on root filled posterior teeth: a systematic review

Focusing on outcomes and methods in removable prosthodontics trials: a systematic review

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