Efficacy of sodium hypochlorite and chlorhexidine against Enterococcus faecalis: a systematic review

Abstract

The efficacy of the sodium hypochlorite (NaOCl) and chlorhexidine (CHX) on Enterococcus faecalis was evaluated by systematic review and meta-analysis. The search strategies included search in electronic biomedical journal databases (MEDLINE, EMBASE, CENTRAL) and handsearching records, using different matches of keywords for NaOCl, CHX and Enterococcus faecalis. From 41 in vivo studies, 5 studies met the inclusion criteria. In a sample containing 159 teeth, E. faecalis was detected initially in 16 (10%) teeth by polymerase chain reaction (PCR) and 42 (26.4%) teeth by microbial culture techniques. After root canal disinfection, this species was observed in 11 (6.9%) teeth by PCR and 12 (7.5%) teeth by culture. Risk differences of included studies were combined as generic inverse variance data type (Review Manager Version 5.0 – Cochrane Collaboration, http://www.cc-ims.net, accessed 15 May 2008), taking into account the separate tracking of positive and negative cultures/PCR. The level of statistical significance was set at p<0.05. In conclusion, NaOCl or CHX showed low ability to eliminate E. faecalis when evaluated by either PCR or culture techniques.

Análise de dois métodos de desinfecção de condutos radiculares após preparo para pinos: proposta de protocolo protético: estudo in vitro

“…Neste intervalo entre o preparo e a cimentação do RIR, pode haver quebra da cadeia asséptica e recontaminação dos canais radiculares 1,5,9,[11][12][13][14] . Diversos trabalhos 1,3,9 apontam que falhas no tratamento endodôntico ou durante a confecção do RIR ocorrem em virtude de trabalhos realizados sem a observação dos princípios biológicos.…”

“…Com o intuito de manter a cadeia asséptica do canal, propostas como soluções irrigantes são importantes no preparo do conduto, pois auxiliam na limpeza e lubrificação do canal radicular, eliminação dos detritos, além de apresentarem efeito antimicrobiano, sem prejuízo para a região periapical 11,12 .…”

“…As substâncias químicas auxiliares mais populares e mais usadas são o Hipoclorito de Sódio (NaOCl) e o Digluconato de Clorexidina (CHX) [11][12][13][14] .…”

Práticas baseadas em evidências publicadas no Brasil: identificação e reflexão na área da prevenção em saúde humana

“…Thus, there were studies that only focused on the prevalence or incidence of health problem events (I) (12)(13)27,32,45,(47)(48)67,81,(83)(84)(85)(86)90,92) ; others to iden fy and/or associate risk factors (II) ( ; and s ll others to correlate interven ons with preven on, prophylaxis or reduc on of events (III) (14)(15)(17)(18)20,23,33,46,(50)(51)(53)(54)(55)58,62,(64)(65)(68)(69)(70)(71)(72)(73)(74)(75)(76)(79)(80)82,89,91,(93)(94) .…”

Antimicrobial evaluation of copper sulfate (II) on strains of Enterococcus faecalis. In vitro study

“…Its great resistance is enhanced by gene transfer, which determines the spread of antibiotic resistance genes, even to other species 4 . This makes it resistant to certain medications, including sodium hypochlorite 5 . Moreover, Enterococcus faecalis survives in alkaline media that inhibit the growth of other bacteria, including calcium hydroxide (CH); a pH of 10.5-11 retards its growth, and only a pH> 11.5 prevents it, allowing the bacteria to survive in the presence of this drug and to proliferate when its action ends 6 .…”