Clinical and urodynamic evaluation in women with stress urinary incontinence treated by periurethral collagen injection

Abstract

Objective: To evaluate the success of treatment with periurethral collagen injections in patients suffering from stress urinary incontinence (SUI) with bladder neck hypermobility and intrinsic sphincter deficiency. Materials and Methods: Forty women suffering from (SUI) were selected and divided into GI (consisting of 13 women with SUI and bladder neck hypermobility) and GII (consisting of 27 women with SUI and intrinsic sphincter deficiency). Periurethral collagen was injected followed by a subjective evaluation (the need for urinary protectors) and an objective evaluation through urodynamic study before and after the treatment. Results: It was noticed that after 9 months there was a decrease in the need of urinary protectors in the two groups. It was observed through the urodynamic study that either cure or improvement was achieved in 46% in GI and 40.7% in GII. There was a significant increase in the leak pressure in GII. Moreover, there was a decrease in the volume of urine leak in the two groups, being the results in GII statistically significant. Conclusions: It was concluded that the periurethral collagen injection is useful for the treatment of the SUI. The results in hypermobility are similar to those in intrinsic sphincter deficiency. In fact, it is a very simple out patient's procedure, with little side effects.

Retrospective Evaluation of Urethral Bovine Cross‐Linked Collagen Implantation for Treatment of Urinary Incontinence in Female Dogs

“…Transurethral GAX collagen has been used as a bulking agent for stress urinary incontinence in women and men for nearly 20 years. Numerous studies have shown its success for improvement in or complete achievement of continence to be 40–93% 4,7–10 . The major drawbacks to its use in humans have been lack of sustained efficacy and the subsequent need for repeated injections, as well as the presence of hypersensitivity to the material in an estimated 4% of patients 9–12 .…”

“…4,7-10 The major drawbacks to its use in humans have been lack of sustained efficacy and the subsequent need for repeated injections, as well as the presence of hypersensitivity to the material in an estimated 4% of patients. [9][10][11][12] Hypersensitivity to the product has not been reported in the dog.…”

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

“…Collagen-based formulations are mainly used for the treatment of several kind of diseases belonging mainly to the musculoskeletal (i.e., hip or knee osteoarthritis [ 112 , 131 , 133 , 140 , 142 , 144 , 182 ], sprained knee pain [ 143 ], injured cartilage [ 138 , 141 ], piriformis syndrome [ 136 ], ankle and hindfoot arthritis [ 103 ] or fusion [ 100 , 106 , 107 , 108 , 109 ], lumbar spinal fusion [ 99 ], myofascial pain syndrome [ 130 , 137 ], chronic pain [ 132 ], acute lumbar spine pain [ 134 ], partial-thickness rotator cuff tears [ 141 , 146 , 183 ], plantar fasciitis [ 184 ], calcific supraspinatus tendinitis [ 145 ], pain [ 130 , 132 , 134 , 137 ]), urogenital (i.e., urinary incontinence [ 122 , 124 , 125 , 185 , 186 , 187 , 188 , 189 ], neurogenic urinary incontinence [ 190 ], lichens sclerosus [ 165 ], intrinsic sphincter deficiency [ 191 , 192 , 193 ], post-prostatectomy incontinence [ 65 , 123 , 194 ,…”

“…Collagen injections have been revealed to be a minimally invasive and quite effective solution for specific urogenital system diseases such as stress urinary incontinence [ 122 , 124 , 125 , 185 , 186 , 187 , 188 , 189 ], neurogenic urinary incontinence [ 190 ], lichens sclerosus [ 165 ], intrinsic sphincter deficiency [ 191 , 192 , 193 ], post-prostatectomy incontinence [ 65 , 123 , 194 , 195 , 196 , 197 ], retrograde ejaculation [ 198 ] and ovarian function after premature ovarian failure [ 212 ].…”

Effectiveness of Periurethral Injection on Stress Urinary Incontinence

“…The re are so me stu di es re por ting he a ling ra tes of 70-90%, and cure ra tes of 10.3-50% with pe ri u ret hral "bul kin g" agents in re al SUI ca ses. [7][8][9][10] Uret hral in jec ti on treat ment is pre fer red for old pa ti ents along with the pa ti ents for whom sur gi cal tre at ment op ti ons may not be uti li zed. The most im por tant ad van ta ge of this met hod is that mor bi dity and comp li ca ti ons are low and it can be app li ed un der lo cal anest hesi a.…”