2005
DOI: 10.1590/s1677-55382005000400014
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Calcium channel blocker and renal mitochondrial function in warm renal ischemia

Abstract: Administration of verapamil before warm ischemia provides partial and short-lasting functional protection of the mitochondrial function in kidneys perfused with sodium rich saline. With Euro-Collins solution, verapamil did not show any additional beneficial effect. This fact permits us to conclude that protective action is effective only under conditions that facilitate increased sodium uptake and/or potassium loss.

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Cited by 10 publications
(8 citation statements)
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“…By preventing the calcium influx, it may help in the decrease of progression of IR injury . It has been detected to protect against renal IR induced in rats …”
Section: Introductionmentioning
confidence: 99%
“…By preventing the calcium influx, it may help in the decrease of progression of IR injury . It has been detected to protect against renal IR induced in rats …”
Section: Introductionmentioning
confidence: 99%
“…ROS per se have also been shown to compromise renal function, depress glomerular filtration, impair glomerular sieving function [5,6,7], and induce apoptosis in renal cells [8]. A range of drugs and methods have been tested with the intention to block the pathways of cell injury at different levels and thereby enhance viability of the kidney challenged by I-R stress with variable results, such as: ischemic preconditioning [9], antioxidants [10,11], dipyridamole [12,13], nicotine [14], and calcium channel blockers [15,16,17,18]. Recent overwhelming attention to plant products and alternative medicine has encouraged plant chemists, pharmacologists and biochemists to combine their efforts in a search for natural agents, such as Allium sativum , Benincasa cerifa (Thunb.…”
Section: Introductionmentioning
confidence: 99%
“…3,4 Lipid peroxidation is an autocatalytic mechanism leading to oxidative destruction of cellular membranes, and their destruction can lead to the production of toxic reactive aldehydic metabolites and cell death. [5][6][7][8] A range of drugs and methods have been tested with the intention to block the pathways of cell injury at different levels and to thereby enhance viability of the kidney challenged by ischemia/ reperfusion stress with variable results, such as: heat shock (interferes with the L-arginine-nitric oxide pathway), 9 antioxidants, 10,11 dipyridamole (increases endogenous adenosine), 12,13 nicotine (inhibit cholinergic antiinflammatory pathway), 14 calcium channel blockers or antagonists, [15][16][17][18] chlorpromazine, 19,20 etc. Chorpromazine (CPZ) is a membrane stabilizer and seems to be able to preserve mitochondria integrity and to reduce phospholipids degradation of microsomal membranes of liver cell provoked by ischemia/reperfusion.…”
Section: Introductionmentioning
confidence: 99%