2008
DOI: 10.1590/s0102-86502008000700008 View full text |Buy / Rent full text
|
|

Abstract: Purpose: To evaluate the influence of chlorpromazine (CPZ) on renal function and lipid peroxidation in a rat model of kidney ischemia/reperfusion injury. Methods: Forty eight Wistar rats underwent a laparotomy for hilar clamping of left kidney with a bulldog clamp for 60 minutes followed by organ reperfusion and contralateral nephrectomy. Of these, 26 received 3mg/kg of CPZ intravenously 15 minutes before renal ischemia (G-E) while the remaining 22 were used as ischemic control group (G-C). Eleven rats of G-E … Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
4
1
1
4
0

Year Published

2015
2015
2021
2021

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

1
4
0
Order By: Relevance
“…In a study of the effect of chlorpromazine on IRI after 60 minutes of ischemia and reperfusion after 5 minutes and 24 hours, Tucci Junior et al showed that MDA levels increased significantly within 5 minutes but returned to its normal level within 24 hours. They attributed their finding to the fact that lipid peroxidation process plays a role in renal injury at the anoxic and pre-reperfusion stages, and MDA level increases and then decreases at the beginning of the reperfusion stage (16). In the present study, the serum nitrite level increased in female rats, which may be due to the effect of female sex hormones on increased NOS expression (17).…”
Section: Discussionsupporting
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 7 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…In a study of the effect of chlorpromazine on IRI after 60 minutes of ischemia and reperfusion after 5 minutes and 24 hours, Tucci Junior et al showed that MDA levels increased significantly within 5 minutes but returned to its normal level within 24 hours. They attributed their finding to the fact that lipid peroxidation process plays a role in renal injury at the anoxic and pre-reperfusion stages, and MDA level increases and then decreases at the beginning of the reperfusion stage (16). In the present study, the serum nitrite level increased in female rats, which may be due to the effect of female sex hormones on increased NOS expression (17).…”
Section: Discussionsupporting
“…[ 32 33 ] It is thought that increasing of MDA concentration occurs in initial times of renal reperfusion, but it returns to near-normal levels 24 h later. [ 34 ] It is known that sex difference in kidney levels of MDA may be related to antioxidant properties of the female sex hormones, estrogen, that can reduce free radicals. [ 35 ] Hence, increased activity of superoxide dismutase or other antioxidant enzymes leads to a reduction in the MDA level.…”
Section: Discussionmentioning
“…From 2001 onwards, new publications, produced in Brazil, have emerged and they show the beneficial usage of chlorpromazine in renal ischemia episodes induced towards renal transplant 13,15,16,18 . The last publication about chlorpromazine was published in 2010 18 , and for this reason new studies are necessary to confirm the benefits of this drug in renal ischemia; it's a cheap and easy-to-use drug.…”
Section: Discussionmentioning
“…There have also been studies towards lipid peroxidation (malondialdehyde count) 16 ; however, such study has alternatively focused on a number of histological items caused by ischemia related to renal architecture and chlorpromazine protective action.…”
Section: Discussionmentioning