Abstract:PURPOSE:To analyze the influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury.
METHODS:Sixteen Wistar rats -split in two groups -have been used: control group, receiving 3 mg/kg isotonic saline solution through caudal vein, and, the chlorpromazine group, receiving 3 mg/kg-IV of such medication. The nephrectomy of the left kidney lower third was carried out; immediately, the test-drug was administrated. After 15 minutes of test-drug administration, the renal pedicle … Show more
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