Preventive Effect of Ginger <i>(Zingiber officinale)</i> Pretreatment on Renal Ischemia-Reperfusion in Rats

Abstract

Background/Aims: The present study examined the preventive effect of ginger against renal ischemia-reperfusion (I-R) injury. Methods: 30 adultmale rats were used. The animals were allocated to five groups of 6 rats: (1) normal (N), (2) normal + ginger (N+G), (3) right nephrectomy (Sham), (4) I-R, and (5) I-R + ginger (I-R+G). To induce renal ischemia, animals were unilaterally nephrectomized and subjected to 45 min of left renal pedicle occlusion with 24 h reperfusion. Ginger was administered orally 24 h and just before ischemia. At the end of the experiment, blood samples and urine were collected. The following renal functional parameters were studied: serum and urinary levels of creatinine and urea, fractional excretion of sodium, and creatinine clearance. Histopathological examination of the kidney was also performed. Results: Rats with renal I-R showed a significant increase in creatinine and urea concentration in serum and also a significant decrease in creatinine clearance compared with the other groups. In addition, renal histopathology in the I-R group showed severe alterations such as tubular dilatation and tubular epithelial necrosis. However, these changes were significantly reduced in the I-R+G group. Conclusion: This study suggests that ginger is a useful agent for the prevention of renal ischemia reperfusion-induced injury.

Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats

“…Also, silymarin, as an antioxidant flavonoid complex derived from the herb milk thistle ( Silybum marianum ), has the ability to scavenge free radicals, chelate metal ions, and inhibit lipid peroxidation [44]. In parallel with our results, ginger recorded a promise role against renal ischemia [45], renal damage induced by alcohol intoxication [46], and renal toxicity induced by doxorubicin, the commonly used anticancer drug [47]. …”

Ginger extract diminishes chronic fructose consumption-induced kidney injury through suppression of renal overexpression of proinflammatory cytokines in rats

“…Ginger has been demonstrated to protect rats from ischemia/reperfusion- [18,19], alcohol- [20,21], streptozotocin- [22] and carbon tetrachloride- [23] induced renal injuries. Recently, we have demonstrated that ginger supplement improves fructose consumption-induced fatty liver [24] and adipose tissue insulin resistance [25] in rats.…”

“…It has been demonstrated that ginger has pleiotropic pharmacological activities, such as gastrointestinal, analgesic, anti-inflammatory, antioxidant and cardiovascular activities [16,17]. The renoprotective effects of ginger have also been reported in the animal models of ischemia/reperfusion- [18,19], alcohol- [20,21], streptozotocin- [22] and carbon tetrachloride- [23] induced renal injuries. However, the efficacy of ginger on the metabolic syndrome-associated kidney damages remains unknown.…”

Gingerol Fraction from Zingiber officinale Protects against Gentamicin-Induced Nephrotoxicity

“…Ginger has been shown to protect against renal ischemia-reperfusion injury and cisplatin-related nephrotoxicity (20,21). In the former case, its use has been associated with an antiapoptotic effect.…”