Effects of high-energy shock wave on organs adjacent to the kidney in the growing rat

Nardi, Aguinaldo Cesar; Ferreira, Ubirajara; Claro, Joaquim Francisco de Almeida; Stopiglia, Gustavo M.; Netto, Nelson Rodrígues

doi:10.1590/s1677-55382004000200012

Cited by 2 publications

(2 citation statements)

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“…The lack of a consensus concerning the choice of time interval to repeat ESWL is due to enormous variability of particular conditions found in the use of ESWL in humans 4,7,20 and the limitations of the animals model [19][20][21] . Our animal model suggests that the mild vascular injury on the renal parenchyma can be recovered in fourteen days, as is showed by the current reports in the biomedical literature 16,18,22 . On the other hand, on diabetic rats the occurence of HF with repetead ESW (A2) was more frequent in the three areas (subcapsular =40%; interstitial =30% and glomerular =10%) than with a single ESW (A4) in the same three areas (subcapsular =25%; interstitial =15% and glomerular =15%).…”

Section: Discussionsupporting

confidence: 81%

The repeated extracorporeal shock waves and the renal parenchyma injury on normal and diabetic rats

et al. 2007

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The repeated extracorporeal shock waves and the renal parenchyma injury on normal and diabetic ratsThe repeated extracorporeal shock waves and the renal parenchyma injury on normal and diabetic rats ABSTRACT Purpose:To assess the effect of repeated extracorporeal shock waves (ESW) on renal parenchyma of normal and diabetic rats. Methods: 40 normal rats (A) and 40 diabetic rats (B) were assigned for ESW (Direx Tripter X1 ® -14 KVA) as follow: A1/B1 and A3/B3 no ESW; A2/B2 one ESW (2,000 SW); A4/B4 two ESW (4,000 SW) in an elapsed 14 days. All the animals were sacrificed 3 days after the ESW and samples of renal parenchyma were histological prepared, stained by H&E. For each animal the frequency of hemorrhage focus (HF) in the subcapasular, interstitial and glomerulus area was calculated (porcentage) on 20 randomly histological sections. Results: No one HF was identified in all normal or diabetic animals without ESW (A1, A3 and B1, B3). In the normal rats the HF frequency was similar to one ESW (subcapsular =15%; interstitial =20% and glomerular =10%) or repetead ESW (subcapsular =25%; interstitial =20%; glomerular=10%). In diabetic rats the occurence of HF with repetead ESW was more frequent (subcapsular =40%; interstitial =30% and glomerular =10%) than with a single ESW (subcapsular =25%; interstitial =15% and glomerular =15%). Conclusion: A single ESW or a repeated ESW caused a mild and similar damage on renal cortex of normal rats. In diabetic rats the repetead ESW may result in an accumulated damage, especially with focus of hemorrhage in subcapsular and interstitial tissue and glomerulus edema. Key words: Kidney. Lithotripsy. High-Energy Shock Waves. Diabetes Mellitus. Rats. RESUMOObjetivo: Avaliar o efeito de repetidas ondas de choque extracorpóreas (OCE) sobre o parênquima renal de ratos normais e diabéticos. Métodos: 40 ratos normais e 40 ratos diabéticos foram distribuídos para aplicação de OCE (Direx Tripter X1 ® -14 KVA) como segue: A1/B1 e A3/B3 sem OCE; A2/B2 uma sessão de OCE (2000 OC); A4/B4 duas sessões de OC (4000 OC) num intervalo de 14 dias. Todos os animais foram sacrificados no 3º. dia após a aplicação da OCE e amostras de parênquima renal foram histologicamente preparados e corados em H&E. Para cada animal foi calculado, em 20 campos aleatórios, a freqüência (em porcentagem) de focos hemorrágicos (FH) nas áreas subcapsular, intersticial e glomerular. Resultados: Nenhum foco hemorrágico foi identificado nos animais normais ou diabéticos que não receberam nenhuma OCE (A1, A3 e B1, B3). Nos ratos normais a freqüência de FH foi similar com uma sessão de OCE (subcapsular =15%; intersticial =20% e glomerular =10%) ou duas sessões de OCE (subcapsular =25%; intersticial =20%; glomerular =10%). Nos ratos diabéticos a ocorrência de FH com duas sessões de OCE foi mais freqüente (subcapsular =40%; intersticial =30% e glomerular =10%) do que com uma simples sessão de OCE (subcapsular =25%; intersticial =15% e glomerular =15%). Conclusão: Uma única ou duas sessões de OCE causa um discreto e semelhante d...

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Section: Discussionsupporting

confidence: 81%

The repeated extracorporeal shock waves and the renal parenchyma injury on normal and diabetic rats

et al. 2007

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“…These concerns have been partially disproved by animal experiments that showed no long lasting influence on bodily growth and no permanent effect on both female and male reproductive systems (15,16). Moreover, the use of a small focusing area provided by the modern devices offered less damage to surrounding tissues (17).…”

Section: Commentsmentioning

confidence: 99%

Extracorporeal shock wave lithotripsy in the treatment of pediatric urolithiasis: a single institution experience

et al. 2010

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Purpose: To compare the efficacy and safety of the electromagnetic lithotripter in the treatment of pediatric lithiasis to that of the earlier electrohydraulic model. Results: In the first group, 21/26 children (80.7%) were stone free at first ESWL session. Colic pain resolved by administration of an oral analgesic in 6 (23%), brief hematuria (< 24 h) resolved with increased fluid intake in 5 (19.2%), while slightly elevated body temperature (< 38°C) occurred in 4 (15.3%). Four children (15.3%) failed to respond to treatment and were treated with ureteroscopy. In the second group 18/19 children were completely stone free at first ESWL session (94.7%). Complications were infrequent and of minor importance: colic pain treated with oral analgesic occurred in 1 (5.26%), brief hematuria (< 24 h), resolved with increased fluid intake in 4 (21%) and slightly elevated body temperature (< 38°C) monitored for 48 hours occurred in 6 (31.5%). Statistical analysis showed that electromagnetic lithotripter is more efficacious and safer than the earlier electrohydraulic model. Conclusions: Technological development not only has increased efficacy and safety of lithotripter devices in treating pediatric lithiasis, but it also provided less painful lithotripsy by eliminating the need for general anesthesia.

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Effects of high-energy shock wave on organs adjacent to the kidney in the growing rat

Cited by 2 publications

References 13 publications

The repeated extracorporeal shock waves and the renal parenchyma injury on normal and diabetic rats

The repeated extracorporeal shock waves and the renal parenchyma injury on normal and diabetic rats

Extracorporeal shock wave lithotripsy in the treatment of pediatric urolithiasis: a single institution experience

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