We aimed to report a case with acute renal insufficiency and hydronephrosis treated by surgical repair of the total uterine prolapse. A 61-year-old woman presented to our clinic with a general weakness, lower abdominal pain, decreased urination and dysuria. Her pelvic examination revealed the fourth-degree uterine prolapse and blood tests demonstrated failure of renal function tests. Abdominal computed tomography showed bilateral hydroureteronephrosis and the prolapsed uterus and the bladder through the pelvis. After acute vital intervention surgical repair of the pelvic floor with vaginal hysterectomy was performed. There were no complications associated with the surgery. The patient's renal function tests returned to normal and urine extraction increased. We suggest renal evaluation should be considered for cases with severe prolapse of the uterus and if hydroureteronephrosis exists, surgical treatment should be performed as soon as possible to prevent irreversible consequences.