Primary vaginal squamous cell carcinoma with bladder involvement in uterine prolapsed patient

Fedus, Tadeusz; Raś, Renata; Książek, Mariusz; Filipowska, Justyna; Kaznowska, Ewa; Skręt-Magierło, Joanna; Barnaś, Edyta

doi:10.1097/md.0000000000008993

Cited by 6 publications

(6 citation statements)

References 24 publications

(17 reference statements)

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“…Squamous cell carcinomas (SCCs), also known as epidermoid carcinomas, are cancers that derived from squamous epithelial cells, which occur in the head and neck, thyroid, esophagus, lung, penis, prostate, bladder, vagina, and cervix [1][2][3][4][5][6][7][8][9]. Of these, head and neck SCC (HNSCC) has attracted the attention of researchers due to its significant etiology including tobacco [10], alcohol [11], and human papilloma virus infection [12] associated with people's lifestyles.…”

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confidence: 99%

Biological role and clinical value of miR‐99a‐5p in head and neck squamous cell carcinoma (HNSCC): A bioinformatics‐based study

et al. 2018

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Micro RNA s (mi RNA s) are confirmed to be tumor promoters or suppressors in multiple squamous cell carcinomas ( SCC s). miR‐99a‐5p has been demonstrated to be downregulated in cancerous tissues, but its functional role in head and neck SCC ( HNSCC ) and its mechanism of action have not been fully elucidated. Here, we studied the expression of miR‐99a‐5p in HNSCC and performed a clinical value assessment and then extracted mature expression data from The Cancer Genome Atlas ( TCGA ) and microarrays from Gene Expression Omnibus ( GEO ). Furthermore, biological analysis was constructed via online prediction tools. The results revealed that miR‐99a‐5p expression was markedly lower in HNSCC tissues than in normal tissues, which also showed significance in the prognosis of HNSCC . However, its diagnostic value could not be verified due to the lack of body fluid samples. Additionally, miR‐99a‐5p was expressed at higher levels in patients with low histological grade neoplasms than those with high histological grade neoplasms. The age of the patient might also be a possible clinical parameter affecting miR‐99a‐5p expression. Furthermore, miR‐99a‐5p significantly influenced HNSCC progression by regulating the PI 3K‐Akt signaling pathway, in which the key target genes were upregulated in 519 HNSCC tissues compared to 44 normal tissues, as determined by the Gene Expression Profiling Interactive Analysis ( GEPIA ). In conclusion, our study may provide insights into the expression and mechanism of miR‐99a‐5p in HNSCC . Further studies are required to elucidate the role of miR‐99a‐5p and its potential clinical applications for HNSCC .

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confidence: 99%

Biological role and clinical value of miR‐99a‐5p in head and neck squamous cell carcinoma (HNSCC): A bioinformatics‐based study

et al. 2018

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“…Rarely, as seen in our patient, due to chronic irritation, primary vaginal cancer may develop secondary to prolonged POP. However, primary vaginal or cervical cancer and POP combination is rarely reported in the literature [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]. The increase in the incidence of both POP and primary vaginal cancer with advancing age makes this combination more frequent in elderly people [1].…”

Section: Discussionmentioning

confidence: 99%

“…Vaginal trauma, chronic irritation, and inflammation of the vaginal mucosa can cause primary vaginal cancer in patients with POP [3]. However, a combination of POP and primary vaginal or cervical cancer is an extremely rare entity [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19].…”

Section: Purposementioning

confidence: 99%

Using a pessary during radiotherapy in reducible pelvic organ prolapse and vaginal cancer: a case report and review of the literature

Gültekin

Esen

Akgör

et al. 2020

jcb

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Purpose: Primary vaginal cancer and pelvic organ prolapse (POP) combination is extremely rare. Although definitive chemoradiotherapy (CRT) and brachytherapy (BT) is the standard treatment for advanced stage primary vaginal cancer, there is a limited data about the treatment of primary vaginal cancer combined with POP due to its rarity. In addition, radiotherapy (RT) process may be difficult in these cases and often result in more toxicity. Case presentation: In this case report, we present a 77-year-old woman with a diagnosis of primary vaginal cancer associated with POP, who was treated with definitive CRT using a pessary to restore vaginal anatomy for optimal radiation. Following CRT, complete response was observed and vaginal cuff BT was performed. The patient tolerated the treatment very well and is still alive without disease at 10-months follow-up. Conclusions: Combined primary vaginal cancer and POP is an extremely rare clinical entity, with only a few cases reported in the literature. When applying CRT in these cases, critical organ doses may be higher than expected due to the downward descent of the pelvic organs. Especially in elderly patients, a pessary can be used as a non-surgical procedure to restore the anatomy for symptom relief during definitive CRT. Additionally, it allows tumors to be targeted more precisely.

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“…Ring pessaries in particular seem to be problematic [12]. However, further case reports of single cases did not allow any conclusion on the referred association, since they were not related to the population of all vaginal carcinomas [7,8,13].…”

Section: Ethicsmentioning

confidence: 98%

Is there an Association between Vaginal Cancer and Genital Prolapse? A Data-Analysis and Review of Literature

Männle¹,

Osorio²,

Momm³

et al. 2021

Int J Oncol Res

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Purpose: Primary vaginal cancer represents a rare disease. The main risk factor for vaginal carcinoma is a persistent human papillomavirus (HPV) infection. However, chronic mechanic irritation of the vagina, have long been suspected to contribute to the development of vaginal cancer. This study examined to assess possible associations between genital prolapse and the incidence of vaginal cancer. Methods:We conducted a systematic literature search regarding the association between vaginal cancer and genital prolapse, supplemented with our own data set of the Centre for Gynaecological Oncology of the Ortenau Clinic Offenburg.Results: Our case analysis of prolapse-associated vaginal carcinomas corresponds to a large extent with the total collective of vaginal carcinomas. The most frequent histological subtype was squamous cell carcinoma in 90%. The median age of patients with genital prolapse-associated vaginal carcinomas was 75 years (72.9 ± 12.1 years). However prolapse associated vaginal cancers had FIGO stage IV more often than cases of vaginal cancer in general. FIGO stage I was reported as most frequent (39%). FIGO stage IV was the second most frequent stage in prolapse associated cases (25%). Furthermore, the Kaplan-Meier curves are significantly different from unselected vaginal cancer cases. In the prolapse associated cases FIGO stages I and II have a far better disease-free survival; in contrast, the prognosis in the advanced stages is much worse. Conclusion:In addition to the HPV infection, patients with genital prolapsed and those with ongoing systemic corticosteroid therapy or other immunocompromising medications, should be perceived as risk groups and regularly examined.

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Primary vaginal squamous cell carcinoma with bladder involvement in uterine prolapsed patient

Cited by 6 publications

References 24 publications

Biological role and clinical value of miR‐99a‐5p in head and neck squamous cell carcinoma (HNSCC): A bioinformatics‐based study

Biological role and clinical value of miR‐99a‐5p in head and neck squamous cell carcinoma (HNSCC): A bioinformatics‐based study

Using a pessary during radiotherapy in reducible pelvic organ prolapse and vaginal cancer: a case report and review of the literature

Is there an Association between Vaginal Cancer and Genital Prolapse? A Data-Analysis and Review of Literature

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