PCA3 rs544190G>A and prostate cancer risk in an eastern Chinese population

Abstract

Background:The association of prostate cancer antigen 3 (PCA3) polymorphism (SNP, rs544190G>A) with metastatic prostate cancer in European descent has been reported. Our aim of the current study was to re-validate the effect of PCA3 polymorphism on prostate cancer risk in an Eastern Chinese population and then estimate possible genetic discrepancies among population.Materials and Methods:Taqman assay was employed to determine genotype of SNP rs544190 in 1015 ethnic Han Chinese patients with prostate cancer and 1032 cancer-free controls. Simultaneously, odds ratios (OR) and 95% confidence intervals (95%CI) for risk relationship were calculated by logistic regression models.Results:The statistically significant relationship between PCA3 rs544190G>A and higher prostate cancer risk was not found. Stratification analysis revealed that there was no remarkable association of rs544190 variant AG/AA genotype with prostate cancer risk in every subgroup, except for patients with Gleason score ≤7(3+4).Conclusion:Although the results demonstrated that SNP rs544190 was not involved in prostate cancer risk in Eastern Chinese descent, unlike in European population, these might have clinical implications on prostate cancer heterogeneity around the World. To validate these findings, well-designed studies with different ethnic populations are warranted.

The Weight of HLA-DPA1 rs3077 Single Nucleotide Polymorphism in Prostate Cancer, a Multicenter Study

“…Thus, presence of multiple risk alleles is more predictive than a single allele. Another study has reported that SNPs confer a cumulative risk of PCa development [ 12 ].…”

“…These discrepancies between results might be attributed to the PCa heterogeneity around the World [ 12 ], location of the SNP [ 22 ] or ethnicity of the studied population, as ethnicity is closely linked to hereditary factors in the genesis of PCa [ 9 , 12 ]. What limits our study is the small sample size, which is attributed to low disease burden in our locality.…”

Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study

“…In addition, vitamin D receptor (VDR) rs7975232 SNP was reported to predict PCa risk in African American men [ 23 ]. However, Cao et al [ 24 ] have reported that PCa antigen 3 SNP (rs544190G > A) was associated with metastatic prostate cancer among the European descent but has no association in the Eastern Chinese population. These results exposed the possible ethnicity-associated polymorphisms.…”

“…They have investigated the influence of the IL-8-251T/A SNP on PCa susceptibility and clinicopathological characteristics in Brazilian patients but did not find any association. These divergences in results could be related to the heterogeneity of PCa [ 24 ], location of the SNP on the gene [ 31 ], and/or ethnic differences [ 24 ].…”