Should routine neonatal circumcision be a policy to prevent penile cancer? | Opinion: No

Tang, Dominic H.; Spiess, Philippe E.

doi:10.1590/s1677-5538.ibju.2017.01.04

Cited by 5 publications

(3 citation statements)

References 19 publications

(25 reference statements)

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“…For SFF with anode exit reservoir and IFF without anode exit reservoir, the steady‐state operation of PEMFC with DEA can be obtained. But the PFF with DEA was not fitted for PEMFC [97] …”

Section: Effects Of Different Flow Field Designsmentioning

confidence: 99%

Performance Studies of Proton Exchange Membrane Fuel Cells with Different Flow Field Designs – Review

Marappan¹,

Palaniswamy

Velumani

et al. 2021

The Chemical Record

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Proton Exchange Membrane Fuel Cell (PEMFC) is majorly used for power generation without producing any emission. In PEMFC, the water generated in the cathode heavily affects the performance of fuel cell which needs better water management. The flow channel designs, dimensions, shape and size of the rib/channel, effective area of the flow channel and material properties are considered for better water management and performance enhancement of the PEMFC in addition to the inlet reactant's mass flow rate, flow directions, relative humidity, pressure and temperature. With the purpose of increasing the output energy of the fuel cell, many flow field designs are being developed continuously. In this paper, the performance of various conventional, modified, hybrid and new flow field designs of the PEMFC is studied in detail. Further the effects of channel tapering, channel bending, landing to channels width ratios, channel cross‐sections and insertion of baffles/blockages/pin‐fins/inserts are reviewed. The power density of the flow field designs, the physical parameters like active area, dimensions of channel/rib, number of channels; and the operating parameters like temperature and pressure are also tabulated.

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“…For SFF with anode exit reservoir and IFF without anode exit reservoir, the steady‐state operation of PEMFC with DEA can be obtained. But the PFF with DEA was not fitted for PEMFC [97] …”

Section: Effects Of Different Flow Field Designsmentioning

confidence: 99%

Performance Studies of Proton Exchange Membrane Fuel Cells with Different Flow Field Designs – Review

Marappan¹,

Palaniswamy

Velumani

et al. 2021

The Chemical Record

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show abstract

“…Other preventive strategies should be used, such as vaccination for HPV and allowing the informed individual to make an informed decision about the surgery. 1,63,65 Cancer of the cervix has also been associated with uncircumcision. Some authors consider circumcision to be a protective factor for HPV penile infection and cervical cancer.…”

Section: Contraindicationsmentioning

confidence: 99%

Phimosis and Circumcision: Concepts, History, and Evolution

2018

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Phimosis is classically characterized by the impossibility of completely withdrawing the foreskin and exposing the glans. A distal preputial narrowing occurs, which may be congenital or acquired. Excess foreskin and the presence of balanopreputial adhesions may be components of this spectrum. Circumcision corresponds to foreskin excision, one of the most commonly performed surgeries in boys, whether for medical or religious reasons. Such a procedure is considered sacred by many peoples around the world as a symbol of faith or even as a ritual of tribal emancipation. The appearance of the procedure in several places and times allowed the development of the surgical technique, today adapted to minimize complications and provide evident medical benefits. We present fundamental physiological and histological concepts, classically described, knowing the natural history of a potential disease. We discuss the emergence and development of surgical techniques still used today and identify factors that interfere with the disease and influence the treatment.

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“…A systematic analysis reported a strong protective effect of circumcision in PSCC overall [odds ratio (OR) ¼ 0.33], although its protective effect was lost in men with no history of phimosis and the risk of PSCC appeared to increase in men circumcised at adulthood, possibly because of selection bias [13]. In contrast, the value of neonatal circumcision for prevention of PSCC was questioned by some authors and improvements in daily hygiene and widespread use of HPV vaccine were considered sufficient to preclude routine neonatal circumcision for the prevention of PSCC, especially in developed western countries [14]. Another concern for neonatal circumcision is its low acceptance by communities unfamiliar with the procedure.…”

Section: Introductionmentioning

confidence: 99%

Treating advanced penile cancer: where do we stand in 2019?

Aydın¹,

Cheriyan²,

Spiess³

2019

Current Opinion in Supportive &Amp; Palliative Care

Self Cite

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Purpose of reviewPenile squamous cell carcinoma (PSCC) remains a challenging malignancy to treat and there is an urgent need of significant improvements at all levels of medical care. In the current review, we summarized the significant obstacles encountered during management of PSCC and discussed the clinical relevance of novel findings and their potential to address these obstacles. Recent findingsThe recent genetic and immunological advances suggest that patients with PSCC can benefit from available targeted therapy and immunotherapy options. Moreover, evidence has accumulated over time suggesting that majority of the patients diagnosed with PSCC suffer from psychosocial problems and impaired rehabilitation. SummaryEffective prevention strategies against PSCC are urgently needed especially in developing countries given the limited therapeutic options. About a quarter of patients with metastatic PSCC appear to benefit from available targeted therapies and about half of the patients can be a suitable candidate for immune checkpoint blockade as half of the PSCC cases exhibit PD-L1 expression. Moreover, increased public awareness, healthcare provider education and social support programs may help patients suffering from PSCC coping with the psychosocial burdens of the disease.

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Should routine neonatal circumcision be a policy to prevent penile cancer? | Opinion: No

Cited by 5 publications

References 19 publications

Performance Studies of Proton Exchange Membrane Fuel Cells with Different Flow Field Designs – Review

Performance Studies of Proton Exchange Membrane Fuel Cells with Different Flow Field Designs – Review

Phimosis and Circumcision: Concepts, History, and Evolution

Treating advanced penile cancer: where do we stand in 2019?

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