Treating advanced penile cancer: where do we stand in 2019?

Abstract

Purpose of reviewPenile squamous cell carcinoma (PSCC) remains a challenging malignancy to treat and there is an urgent need of significant improvements at all levels of medical care. In the current review, we summarized the significant obstacles encountered during management of PSCC and discussed the clinical relevance of novel findings and their potential to address these obstacles. Recent findingsThe recent genetic and immunological advances suggest that patients with PSCC can benefit from available targeted therapy and immunotherapy options. Moreover, evidence has accumulated over time suggesting that majority of the patients diagnosed with PSCC suffer from psychosocial problems and impaired rehabilitation. SummaryEffective prevention strategies against PSCC are urgently needed especially in developing countries given the limited therapeutic options. About a quarter of patients with metastatic PSCC appear to benefit from available targeted therapies and about half of the patients can be a suitable candidate for immune checkpoint blockade as half of the PSCC cases exhibit PD-L1 expression. Moreover, increased public awareness, healthcare provider education and social support programs may help patients suffering from PSCC coping with the psychosocial burdens of the disease.

Efficacy of Applying Kanglaite Injection under Incentive Nursing Intervention in Treating Patients with Advanced Penile Carcinoma and Its Effect on Treatment Compliance

“…As the concept of medical treatment has been changed in Chinese residents, the psychological state of patients with advanced cancer has become a recognized evaluation criterion for efficacy in the academic community [ 20 ], the nursing model solely centered on treatment can no longer meet the needs of clinical care, and the more targeted nursing based on humanities care and with remodeling of the patients' personality and dignity as an essence has become the important development direction in the care of such patients. INI is the more common nursing model for cancer patients in recent years, which aims to integrate emotional and physical support into all aspects of nursing, to make patients fully feel the care of nursing personnel, and thus be more cooperative with the nursing personnel's actions during clinical treatment [ 21 ].…”