Does platelet activity play a role in the pathogenesis of idiopathic ischemic priapism?

Abstract

Purpose Mean platelet volume (MPV) is used to measure platelet size and is defined as a potential marker of platelet reactivity. Higher MPV levels have been defined as a risk factor for increased incidence of intravascular thrombosis and its associated diseases. We aimed to determine whether a relationship exists between the MPV and veno-occlusive component of idiopathic ischemic priapism (IIP).Materials and methods Between 2010 and 2014, 38 subjects were analyzed in two groups. One was composed of 15 patients with diagnosis as IIP in our institute, and the other contained 23 healthy control subjects. Complete blood count reports were retrospectively evaluated in both groups. MPV, platelet count (PLT), platelet distribution width (PDW), white blood cells (WBC), red blood cells (RBC), hemoglobin (Hb), reticulocyte distribution width (RDW) were measured in both groups. :Results The mean ages were similar in IIP patients (45.86±15.82) and control subjects (47.65±10.99). The mean MPV values of IIP patients were significantly higher than control subjects (p<0.05). In contrast, also PLT counts were significantly lower in IIP patients, compared to control subjects (p<0.05). The mean hemoglobin and WBC values were significantly lower in control group (p<0.05). There was no significant difference of RBC, PDW and RDW values in both groups.Conclusions We found that the MPV was significantly higher in IIP patients compared to control subjects. The high MPV levels may have contributed to the veno-occlusive etiopathogenesis of IIP disease. We strongly suggest further prospective studies to recommend the use of MPV in routine practice.

Ischemic priapism: Can eosinophil count and platelet functions be positive predictive factors in etiopathogenesis

“…10 Similarly to the study by Ufuk et al, our study showed that PC and MPV demonstrating platelet activation in the IP group were statistically significantly high. The significance of our study was the addition of EC as a suspected predictive factor for the parameters compared.…”

“…We especially wanted to examine the contribution of EC, PC, and MPV values, which are suspected predictive parameters for vascular endothelium damage and venoocclusive pathogenesis and etiopathogenesis, particularly in IP. To the best of our knowledge, no studies have yet demonstrated the relationship between EC and IP and only one study examined the relationship between platelet activity and priapism, 10 although predictive value and cutoff values were not stated in this study. Ours is the first study examining the relationship between IP and EC-platelet activation and providing predictive and cutoff values.…”

Can haematologic parameters be used to predict testicular viability in testicular torsion?

“…As shown by previous studies, MPV is influenced by thrombosis and endovascular processes (Beyazyildiz, Citirik, Simsek, Beyazyildiz, & Haznedaroglu, ; Braekkan et al, ; Cil et al, ; Sahin et al, ; Vagdatli et al, ). It has been reported to increase in urological vascular pathologies such as ischaemic priapism (Ufuk et al, ). Studies have shown that testicular venous congestion causes formation of vascular microthrombi that induce the intrinsic coagulation pathway, and MPV might be elevated in TT because this condition causes vascular pathology (Bajory, Szabo, Deak, Varga, & Pajor, ; Cicek et al, ; Rattansingh, Adamson, & Cosgrove, ).…”

Platelet volume parameters as a tool in the evaluation of acute ischemic priapism in patients with sickle cell anemia

“…Because of the vasculopathy, chronic hemolysis, and veno-occlusive pathogenesis of SCA, multiple hematologic markers are needed to predict the outcome of IP in SCA patients. The role of platelet count (PLT) and mean platelet volume (MPV) in these veno-occlusive mechanisms is well documented (7)(8)(9)(10)(11). Previous studies confirmed the association between IP, defined as a vasculogenic disease, and platelet activation leading to higher MPV (9,10).…”