Can haematologic parameters be used to predict testicular viability in testicular torsion?

He, Meng; Zhang, Weiping; Sun, Ning

doi:10.1111/and.13357

Cited by 13 publications

(21 citation statements)

References 16 publications

(18 reference statements)

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“…Our previous studies have found that MPV could be used to predict the testicular salvage rate during the window phase (8–51 hr). After our follow‐ups, we were surprised to find that MPV might predict testicular atrophy after surgery; the cut‐off value was 9.9 fl (He, Zhang, & Sun, ). Although this group of patients showed positive results, we still have reservations about whether MPV can really predict long‐term prognosis.…”

Section: Discussionmentioning

confidence: 99%

Prognosis of testicular torsion orchiopexy

Zhang

2019

Andrologia

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| INTRODUC TI ONTesticular torsion, a urological emergency, is the main cause of paediatric acute scrotal pain. The main manifestation of testicular torsion is the decrease of testicular blood flow, which is caused by the spermatic cord twisting on itself around its longitudinal axis. The incidence of males under 25 years old who suffer from testicular torsion is 1:4,000 (Barada, Weingarten, & Cromie, 1989;Pogorelic et al., 2016).Most studies that have been conducted have focused on identifying potential indicators that predict testicular activity during surgery, such as symptom duration and the degree of spermatic cord torsion; however, only a few focused on whether testicular atrophy occurred in children who undergo orchiopexy. A study showed that testicular atrophy occurs in half of the number of children with orchiopexy (Lian, Ong, Chiang, Rai, & Nah, 2016).In our previous studies, we found that the duration of onset, the degree of spermatic cord torsion and the mean platelet volume (MPV) could predict intra-operative testicular activity, but our study did not reveal the long-term prognosis of these children. In this study, we continue to follow up these patients who underwent orchiopexies in order to observe whether testicular atrophy had occurred. Furthermore, we aim to identify any influencing factors regarding atrophy. | MATERIAL S AND ME THODSChildren with testicular torsion who underwent orchiopexy and who were consecutively treated in Beijing Children's Hospital from January 2006 to December 2018 were enrolled in this study.Surgery was performed by paediatric urologists who have more than 5 years of clinical experience. After the twisted spermatic AbstractThe purpose of this study was to follow up patients who underwent testicular torsion orchiopexies in order to observe whether testicular atrophy had occurred and to identify any influencing factors regarding atrophy. Patient data collected in this study included age, symptom duration, pre-operative preparation time, cryptorchidism testicular torsion, spermatic cord torsion degree, ultrasound findings at least 6 months after orchiopexy, testicular atrophy, mean platelet volume (MPV), address and medical insurance. Twenty-nine patients with a mean age of 147 (126.5-163) months involved in our study. The duration of follow-up ranged from 6 to 33 months with a median follow-up duration of 12 (8.5-21) months. Only MPV was significantly different between the atrophy group and nonatrophic group (p = .022) and the receiver operating characteristic (ROC) curve revealed that the cut-off value for MPV atrophy was 9.9 fl, with a sensitivity of 81.8% and a specificity of 70.6%. In conclusion, we found that 41.4% patients eventually experienced testicular atrophy after performing the testicular salvage procedure. MPV might be used as an indicator of testicular atrophy after an operation; however, the accuracy of MPV needs to be confirmed using significant follow-up prospective studies. K E Y W O R D SMPV, orchiopexy, tesiticular torsion, testicular atrophy

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Section: Discussionmentioning

confidence: 99%

Prognosis of testicular torsion orchiopexy

Zhang

2019

Andrologia

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“…9 10 Several studies confirmed that there is a relationship between testicular torsion, defined as an acute vascular disease, and platelet activation which results in higher mean platelet volume (MPV). [11][12][13] Therefore, platelet volume indices (PVIs) can be introduced as potential markers of early diagnosis of testicular torsion.…”

Section: Key Messagesmentioning

confidence: 99%

High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia

Adawi

Ghanem

et al. 2022

World Jnl Ped Surgery

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ObjectiveThis study aimed to evaluate the predictive value of platelet volume indices (PVI), such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as prognostic indicators of testicular viability in torsion patients with steady-state sickle cell anemia (SCA) who underwent surgical exploration.MethodsForty-eight patients with SCA with testicular torsion and 46 male control subjects were enrolled in the study. All patients underwent scrotal color Doppler ultrasonography before surgery, and PVI (MPV, PDW, and PCT) values were measured in all participants. Symptom duration and testicular volume were also recorded.ResultsThe testicular salvage rate in patients with SCA was 73% after surgery. Analyses showed that MPV, PDW, and PCT values were significantly higher in torsed SCA as compared with controls (p<0.05). Orchiectomy in patients with SCA showed significantly higher MPV, PDW, and PCT values than the orchiopexy group (p<0.05). The MPV values of orchiectomy patients showed a higher significant cut-off of ≥11.5 fL, which is higher than in torsed patients without SCA, as an indicator of testis survival. PDW also demonstrated a higher significant cut-off of ≥12.7 fL for detorsion outcomes in patients with SCA. Symptom duration of less than 7 hours was also significantly correlated with orchiopexy (p≤0.001). Univariate analysis showed that higher MPV, increased PDW, and symptom duration were indicative of the outcome of testicular detorsion in SCA. Multivariable analysis showed that increased PDW and symptom duration are prognostic parameters for testicular viability in SCA.ConclusionIncreased PDW and symptom duration can be used as parameters for predicting testicular detorsion outcomes in patients with steady-state SCA.

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“…There are studies reporting that there is a relationship between haematological parameters and testicular recovery rate (He, Zhang, & Sun, 2019; Peretti et al, 2019; Jang et al, 2019). He et al.…”

Section: Discussionmentioning

confidence: 99%

“…He et al. (2019) reported that there was a relationship between MPV, symptom duration and degree of spermatic cord torsion and viability of the testicle. Peretti et al (2019) reported that MPV was a parameter showing testicle viability in TT patients presenting in less than 6 hr of symptom duration.…”

Section: Discussionmentioning

confidence: 99%

“…Although there is a study showing that MPV is significantly higher in TT group than the control group (Cicek et al., 2015), the number of studies reporting that there is no significant difference is higher (Güneş et al., 2015; Yucel & Ozlem Ilbey, 2019; Bitkin et al, 2018). In addition, there are studies reporting that MPV is a parameter indicating testicular viability in TT patients (He et al, 2019; Peretti et al, 2019). In our study, MPV did not differ significantly between the groups.…”

Section: Discussionmentioning

confidence: 99%

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Comprehensive examination of haematological parameters of patients operated due to testicular torsion

Merder

Bozkurt²,

Sezgin

et al. 2020

Andrologia

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Testicular torsion therapy is surgical or manual detorsion. If the testicle has lost its viability, the treatment is orchiectomy. Orchiectomy decision is decided by intraoperative evaluation. The first 6-hr period is critical for testicular torsion (Kapoor, 2008). The parameters that predict the probability of orchiectomy pre-operatively are limited. Therefore, recently studies evaluating the relationship between haematological parameters and testicular torsion have been conducted and different results have been observed. By analysing these conflicting results in the literature, we aimed to investigate the pre-operative predictive role of haematological parameters for orchiectomy in patients with testicular torsion.

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Can haematologic parameters be used to predict testicular viability in testicular torsion?

Cited by 13 publications

References 16 publications

Prognosis of testicular torsion orchiopexy

Prognosis of testicular torsion orchiopexy

High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia

Comprehensive examination of haematological parameters of patients operated due to testicular torsion

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