Severity of erectile dysfunction is highly correlated with the syntax score in patients undergoing coronariography

Abstract

Objective To investigate the association between the severity of erectile dysfunction (ED) and coronary artery disease (CAD) in men undergoing coronary angiography for angina or acute myocardial infarct (AMI).Material and Methods We studied 132 males who underwent coronary angiography for first time between January and November 2010. ED severity was assessed by the international index of erectile function (IIEF-5) and CAD severity was assessed by the Syntax score. Patients with CAD (cases) and without CAD (controls) had their IIEF-5 compared. In the group with CAD, their IIEF-5 scores were compared to their Syntax score results.Results We identified 86 patients with and 46 without CAD. The IIEF-5 score of the group without CAD (22.6±0.8) was significantly higher than the group with CAD (12.5±0.5; p<0.0001). In patients without ED, the Syntax score average was 6.3±3.5, while those with moderate or severe ED had a mean Syntax score of 39.0±11.1. After adjustment, ED was independently associated to CAD, with an odds ratio of 40.6 (CI 95%, 14.3-115.3, p<0.0001). The accuracy of the logistic model to correctly identify presence or absence of CAD was 87%, with 92% sensitivity and 78% specificity. The average time that ED was present in patients with CAD was 38.8±2.3 months before coronary symptoms, about twice as high as patients without CAD (18.0±5.1 months).Conclusions ED severity is strongly and independently correlated with CAD complexity, as assessed by the Syntax score in patients undergoing coronariography for evaluation of new onset coronary symptoms.

Relationship between circulating VCAM-1, ICAM-1, E-selectin and MMP9 and the extent of coronary lesions

“…Similar data were recently reported in a study of 100 patients of both genders undergoing coronary angiography for diagnostic purposes, showing that 37% of those patients had no atherosclerotic lesions 12 . Our hypothesis is also supported by other authors, whom have emphasized the absence of non-invasive methods, clinical symptoms or laboratory tests that are capable of detecting individuals who will develop CAD 1 .…”

“…Cardiovascular disease is the leading cause of death worldwide. Obtaining knowledge about its physiopathology seems to be the best approach to reducing morbidity, mortality, and health care costs, since there are no non-invasive methods, laboratory tests or clinical symptoms that are capable of detecting which individuals will develop coronary artery disease (CAD) 1 .…”

Perception of the association between erectile dysfunction and cardiovascular disease among Chinese physicians: an online survey

“… 5 , 9 The severity of erectile dysfunction, which is evaluated by the 5-item version of the International Index of Erectile Function, was also reported to correlate with CVD and may lead to a difference in specific CVD outcomes. 10 – 12 …”

Do Urologists Really Recognize the Association Between Erectile Dysfunction and Cardiovascular Disease?

“…IIEF-5 could initially be applied to the assessment of ED. 25 Andrade et al 26 reported that the IIEF-5 score of the patients without CAD was significantly higher than the score of the patients with CAD. Moreover, urologists' evaluation of CVDs in patients with ED was also not updated.…”