Perception of the association between erectile dysfunction and cardiovascular disease among Chinese physicians: an online survey

Li, Dongjie; Liao, Zhangcheng; Zhang, Xiaobo; Tang, Yuxin; Zu, Xiongbing; Wang, Long; Yang, Yang; Peng, Hua; Li, Xiucheng; Chen, Xiaoping

doi:10.1177/0300060519894187

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…Urologists are more aware of the association between CVD and ED than are cardiologists. 29 Combining previous research with our results, it is important that cardiologists inform CVD patients about the risk for secondary ED and that they provide more clinical guidance and attention in order to improve CVD patients' physical and mental health.…”

Section: Discussionsupporting

confidence: 56%

Causal association of cardiovascular disease with erectile dysfunction: a two‐sample bidirectional Mendelian randomization analysis

Chen²,

et al. 2023

Andrology

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BackgroundThe association between cardiovascular diseases (CVD), including ischemic stroke (IS), heart failure (HF), myocardial infarction (MI), and coronary heart disease (CHD), and erectile dysfunction (ED) remains unclear from observational studies.ObjectivesWe explored the potential bidirectional association between CVD and ED by Mendelian randomization (MR).MethodsData from genome‐wide association studies for CVD in individuals with European ancestry were obtained from several databases, with 1,711,875–977,323 participants, while that for ED included 223,805 participants. We conducted univariate MR (UVMR), inverse variance‐weighting (IVW), weighted median, MR‐Egger, and multivariate MR (MVMR) analyses to explore the bidirectional causal effects between CVD and ED.ResultsUVMR indicated that IS (odds ratios [OR] = 1.34, 95% confidence interval [CI]: 1.08–1.21, P = 0.007), HF (OR = 1.36, 95% CI 1.07–1.74, P = 0.013), and CHD (OR = 1.15, 95% CI 1.09–1.18, P = 0.022) were associated with ED. By MVMR, IS estimates remained significant after accounting for combining single nucleotide polymorphisms from CVDs (OR = 1.42, 95%CI: 1.13–1.79, P = 0.002). Moreover, the effect of a genetic susceptibility to IS on ED was not mediated by type 2 diabetes or triglycerides; that of HF was not mediated by type 2 diabetes, and that of CHD was not mediated by body mass index. Bidirectional analyses showed that genetic susceptibility to ED did not confer any increased CVD risk.ConclusionsOur results, based on MR, indicated that genetic susceptibility to IS, HF, and CHD was causally associated with ED. These findings can inform prevention and intervention strategies for ED in IS, HF, and CHD patients.

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Section: Discussionsupporting

confidence: 56%

Causal association of cardiovascular disease with erectile dysfunction: a two‐sample bidirectional Mendelian randomization analysis

Chen²,

et al. 2023

Andrology

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“…Several risk factors are common to both ED and CVD ( 40 , 41 ). It is important to recognize the connection between ED and CVD in order to effectively prevent and treat both conditions ( 42 , 43 ). Additionally, ED significantly impacts patients’ quality of life.…”

Section: Discussionmentioning

confidence: 99%

The indicative effects of apolipoproteins on organic erectile dysfunction: bridging Mendelian randomization and case-control study

Zhang,

Yan,

et al. 2024

Front. Endocrinol.

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The existing research on the association between apolipoproteins (Apos) and erectile dysfunction (ED) primarily relies on observational studies and does not distinguish between organic and psychogenic causes when diagnosing ED. It is difficult to believe that Apos play a role in psychogenic ED. To address these issues, our study explored the causal relationship between lipoproteins and ED using Mendelian randomization (MR) analysis and differentiate between organic and psychogenic ED through the use of nocturnal penile tumescence and rigidity (NPTR) monitoring. Multivariate MR analysis revealed significant causal associations between high-density lipoprotein (HDL), Apo A1, and Apo B/A1 with ED (OR and 95% CI were 0.33 (0.14-0.78), 3.58 (1.52-8.43), and 0.30 (0.13-0.66)). we conducted statistical and analytical analyses on the data of 212 patients using multivariate analyses and receiver operating characteristic (ROC) curves. Patients with organic ED had significantly lower levels of HDL, Apo A1 and Apo A1/B, whereas patients with organic ED had considerably higher levels of Apo B and low-density lipoprotein (LDL). The diagnostic value of Apos in predicting the risk of organic ED was evaluated using ROC curves. The results indicated that Apo A1 and Apo A1/B demonstrated good predictive value. HDL, Apo A1, and Apo A1/B have been identified as risk factors for ED in our study. Furthermore, our research highlights the significance of Apo A1 and Apo A1/Apo B in the development of organic ED and suggests their potential use as indicators to assess the risks associated with organic ED.

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“…ED and CVD share several common risk factors (23,24). It is inadequate and underestimated to prevent and treat cardiovascular disease in patients with ED as well as to prevent and treat cardiovascular disease risk in individuals with ED (25,26). However, ED has a substantial in uence on patients' quality of life.…”

Section: Discussionmentioning

confidence: 99%

The Indicative Effects of Apolipoproteins on organic Erectile Dysfunction Diagnosed by the Nocturnal Penile Tumescence and Rigidity Test

Zhang¹,

Li²,

Yang³

et al. 2023

Preprint

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Background Erectile dysfunction (ED) is closely associated with cardiovascular diseases (CVD). Apolipoprotein (Apo) B, Apo A1, and Apo A1/Apo B are predictive indicators of CVD. A strong association among these proteins, ED and CVD has been partially demonstrated. However, Previous studies have confirmed the correlation between apolipoproteins and ED, but does not confirm that apolipoproteins are associated with organic ED but not with psychogenic ED. The results of the The nocturnal penile tumescence and rigidity (NPTR) test and the scale allowed the diagnosis of organic or psychogenic ED, and we more accurately confirmed the association between Apo B, Apo A1, Apo A1/Apo B and organic ED. Results In our study, patients with organic ED had considerably lower levels of Apo A1 and Apo A1/Apo B (P = .013 and P < .001, respectively), whereas patients with organic ED had considerably higher levels of Apo B (P = .024). With an AUC of 0.612 (95% CI: 0.537–0.688, cut-off < 0.95) and 0.655 (95% CI: 0.581–0.728, cut-off < 1.263), respectively, Apo A1 and Apo A1/Apo B exhibited a medium diagnostic value for the risk of organic ED, according to the ROC curve; however, Apo B had no sufficient diagnostic value. Conclusion According to our findings, through the NPTR test, Apo B, Apo A1, and Apo A1/Apo B were all risk factors for organic ED and CVD, but not for psychogenic ED. Additionally, it demonstrated that the proteins Apo A1 and Apo A1/Apo B are crucial in the genesis of organic ED and can be utilized as indicators to evaluate the risks of organic ED.

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Perception of the association between erectile dysfunction and cardiovascular disease among Chinese physicians: an online survey

Cited by 4 publications

References 33 publications

Causal association of cardiovascular disease with erectile dysfunction: a two‐sample bidirectional Mendelian randomization analysis

Causal association of cardiovascular disease with erectile dysfunction: a two‐sample bidirectional Mendelian randomization analysis

The indicative effects of apolipoproteins on organic erectile dysfunction: bridging Mendelian randomization and case-control study

The Indicative Effects of Apolipoproteins on organic Erectile Dysfunction Diagnosed by the Nocturnal Penile Tumescence and Rigidity Test

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