Do Urologists Really Recognize the Association Between Erectile Dysfunction and Cardiovascular Disease?

Li, Dongjie; Li, Xiucheng; Peng, Emin; Liao, Zhangcheng

doi:10.1016/j.esxm.2019.12.002

Cited by 5 publications

(5 citation statements)

References 41 publications

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“…The acceptance value (AV) was determined using Equation (3). AV = (X − M) + KS (3) where X represents the average drug content, S represents the standard deviation and K represents a constant that is either 2.4 for 10 dosage units or 2.0 for 30 dosage units. If 98.5% ≤ X ≤ 101.5%; M = X, if X < 98.5%; M = 98.5%, if X > 101.5%; M = 101.5%.…”

Section: Flowabilitymentioning

confidence: 99%

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Exploitation of Design-of-Experiment Approach for Design and Optimization of Fast-Disintegrating Tablets for Sublingual Delivery of Sildenafil Citrate with Enhanced Bioavailability Using Fluid-Bed Granulation Technique

et al. 2021

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Sildenafil citrate undergoes first-pass metabolism, resulting in poor oral bioavailability at 25–41% of the administered dose. This study aimed to design and optimize fast-disintegrating tablets for the sublingual delivery of sildenafil citrate to improve bioavailability and facilitate rapid onset of action. The design-of-experiment (DoE) approach using 32 full factorial design was conducted to develop a new formulation of sildenafil fast-disintegrating sublingual tablets (FDSTs) using the fluid-bed granulation technique. The levels of partially pre-gelatinized starch (5–15%) and microcrystalline cellulose (10–60%) were selected as independent formulation variables. The prepared FDSTs were investigated for physical properties. Further, the optimum formulation was chosen for in vivo study in rabbits. Regression analysis showed that independent variables have a significant (p < 0.05) influence on critical attributes of FDSTs. The optimized formulation showed acceptable mechanical strength (friability <1.0%) with very fast disintegration (14.561 ± 0.84 s) and dissolution (94.734 ± 2.76% after 15 min). Further, the optimized formulation demonstrated a significant increase (p < 0.01) in Cmax and AUC0–∞ with short tmax compared to the market product (Viagra®). Based on these results, using the DoE approach, a high level of assurance was achieved for FDSTs’ product quality and performance.

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Section: Flowabilitymentioning

confidence: 99%

“…Globally, the prevalence of ED is rated to be roughly 322 million cases by 2025 [2]. A recent study indicated that, 52% of men between the ages of 40 and 70 years suffered from ED [3]. It causes deep negative influence on an individual's social life and prosperity [1].…”

Section: Introductionmentioning

confidence: 99%

Exploitation of Design-of-Experiment Approach for Design and Optimization of Fast-Disintegrating Tablets for Sublingual Delivery of Sildenafil Citrate with Enhanced Bioavailability Using Fluid-Bed Granulation Technique

et al. 2021

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“…Several risk factors are common to both ED and CVD ( 40 , 41 ). It is important to recognize the connection between ED and CVD in order to effectively prevent and treat both conditions ( 42 , 43 ). Additionally, ED significantly impacts patients’ quality of life.…”

Section: Discussionmentioning

confidence: 99%

The indicative effects of apolipoproteins on organic erectile dysfunction: bridging Mendelian randomization and case-control study

Zhang,

Yan,

et al. 2024

Front. Endocrinol.

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The existing research on the association between apolipoproteins (Apos) and erectile dysfunction (ED) primarily relies on observational studies and does not distinguish between organic and psychogenic causes when diagnosing ED. It is difficult to believe that Apos play a role in psychogenic ED. To address these issues, our study explored the causal relationship between lipoproteins and ED using Mendelian randomization (MR) analysis and differentiate between organic and psychogenic ED through the use of nocturnal penile tumescence and rigidity (NPTR) monitoring. Multivariate MR analysis revealed significant causal associations between high-density lipoprotein (HDL), Apo A1, and Apo B/A1 with ED (OR and 95% CI were 0.33 (0.14-0.78), 3.58 (1.52-8.43), and 0.30 (0.13-0.66)). we conducted statistical and analytical analyses on the data of 212 patients using multivariate analyses and receiver operating characteristic (ROC) curves. Patients with organic ED had significantly lower levels of HDL, Apo A1 and Apo A1/B, whereas patients with organic ED had considerably higher levels of Apo B and low-density lipoprotein (LDL). The diagnostic value of Apos in predicting the risk of organic ED was evaluated using ROC curves. The results indicated that Apo A1 and Apo A1/B demonstrated good predictive value. HDL, Apo A1, and Apo A1/B have been identified as risk factors for ED in our study. Furthermore, our research highlights the significance of Apo A1 and Apo A1/Apo B in the development of organic ED and suggests their potential use as indicators to assess the risks associated with organic ED.

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“…Many cardiologists recognize the relationship between ED and CVD, but many people believe that ED is a natural aging process rather than a disease. 20 Therefore, cardiologists do not pay enough attention to the ED in the clinic. However, the effect of ED on the quality of life of patients is very significant.…”

Section: Discussionmentioning

confidence: 99%

The Suggestive Effect of Apo A, Apo B, and Apo A/Apo B on Erectile Dysfunction

2021

The Journal of Sexual Medicine

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Background Erectile dysfunction (ED) is closely related to coronary heart disease (CHD). Apolipoprotein (Apo) A1, Apo B, and Apo A/Apo B are known to be predictive factors for CHD. They are not yet a definite laboratory marker for the diagnosis of ED in cardiology. Therefore, we investigated the association between Apo A1, Apo B, and Apo A/Apo B, and ED. Aim To investigate the association between Apo A, Apo B, and Apo A/Apo B and the severity of ED. Methods A total of 152 ED patients and 39 healthy control participants underwent a fasting blood draw to test for Apo A, Apo B, and Apo A/Apo B and a detailed laboratory examination. The International Erectile Function Index (IIEF-5) was used to determine the severity of ED. Receiver operating characteristic (ROC) curve analysis was performed to identify the cutoff values for Apo A, Apo B, and Apo A/Apo B. Each questionnaire was completed before any diagnosis was made or treatment performed. Outcomes Several lipid profile indicators (Apo A, Apo B, Apo A/Apo B, lipoprotein (a), free fatty acids, and total cholesterol) were studied, along with several questionnaires. RESULTS In our study, the number of patients with no ED, mild ED, mild-to-moderate ED, and moderate-to-severe ED were 39 (20.4%), 58 (30.4%), 36 (18.8%), and 58 (30.4%), respectively. Apo A and Apo A/Apo B were significantly reduced in patients with more severe ED (P = .037 and P < .001, respectively), while Apo B was significantly increased in patients with more severe ED (P = .002). According to the ROC curve, Apo A/Apo B had a medium diagnostic value for risk of ED with an AUC of 0.743 (95% CI: 0.68–0.80). For moderate-to-severe ED, 3 apolipoprotein indexes, including Apo B, Apo A, and Apo A/Apo B had medium diagnostic performance with AUCs of 0.759 (95% CI: 0.66–0.84), 0.703 (95% CI: 0.60–0.79), and 0.808 (95% CI: 0.72–0.88), respectively. Clinical implications Our results can inform cardiologists in the assessment of ED in patients with CHD. Strengths and limitations This study is the first to investigate the association between apolipoprotein and ED in China. The major limitations are that our sample size was too small to have matched controls without ED for different Apo levels. CONCLUSION Our results showed that Apo B, Apo A, and Apo A/Apo B can be used as markers to evaluate the risk of ED and that these proteins play an important role in the etiology of ED.

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Do Urologists Really Recognize the Association Between Erectile Dysfunction and Cardiovascular Disease?

Cited by 5 publications

References 41 publications

Exploitation of Design-of-Experiment Approach for Design and Optimization of Fast-Disintegrating Tablets for Sublingual Delivery of Sildenafil Citrate with Enhanced Bioavailability Using Fluid-Bed Granulation Technique

Exploitation of Design-of-Experiment Approach for Design and Optimization of Fast-Disintegrating Tablets for Sublingual Delivery of Sildenafil Citrate with Enhanced Bioavailability Using Fluid-Bed Granulation Technique

The indicative effects of apolipoproteins on organic erectile dysfunction: bridging Mendelian randomization and case-control study

The Suggestive Effect of Apo A, Apo B, and Apo A/Apo B on Erectile Dysfunction

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