Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

Şeçkiner, İlker; Bayrak, Ömer; Çan, Murat; Mungan, Ayca Gorkem; Mungan, N.A.

doi:10.1590/s1677-5538.ibju.2014.04.17

Cited by 25 publications

(13 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, similar to other studies GS administration directed to significant increase in serum creatinine and urea (6,13,(22)(23)(24). Treatment with DMSO improved serum creatinine and urea significantly in comparison with second group.…”

Section: Discussionsupporting

confidence: 90%

Effect of dimethyl sulfoxide in combat with gentamicin induced nephrotoxicity in rats

et al. 2019

View full text Add to dashboard Cite

Introduction: Gentamicin sulphate (GS) induces nephrotoxicity by increasing of reactive oxygen species (ROS). Objectives: The aim of this research was to assess the renoprotective effect of dimethyl sulfoxide (DMSO) as an antioxidant agent against GS-induced nephrotoxicity. Materials and Methods: Forty male rats (Sprague-Dawley) were divided equally in to five groups and were treated as follows; group 1; received normal saline and served as normal controls, group 2; received GS (100 mg/kg/d), groups 3; received GS and DMSO (0.5 mL/kg/d), groups 4; received GS and DMSO (1 mL/kg/d), groups 5; received GS and DMSO (2 mL/kg/d). After eight days of treatment, serum was prepared. Paraffin sections (3 µ thickness) were prepared from the left kidneys and stained through periodic acid-Schiff (PAS) method. Serum creatinine and urea were assessed by the kits and serum malondialdehyde (MDA) was assessed by thiobarbituric acid (TBA) test. Volume density of proximal tubules, tubular necrosis, tubular cast and lymphocyte infiltration were evaluated histopathologically. The data were analyzed by Mann-Whitney U test at P< 0.05 by SPSS 12 software. Results: Serum MDA, creatinine, urea, tubular volume density, tubular necrosis, tubular cast and lymphocyte infiltration were ameliorated significantly in groups four and five compared with group two (P<0.05). Conclusion: DMSO improved GS-induced renal toxicity significantly through prevention of lipid peroxidation and inflammation, but could not save kidney functional tests and histological changes at the same level as that of the normal group.

show abstract

Section: Discussionsupporting

confidence: 90%

Effect of dimethyl sulfoxide in combat with gentamicin induced nephrotoxicity in rats

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The ability of GE to counteract GNT-induced nephrotoxicity was previously reported (El-Kashef et al 2015;Seckiner et al 2014). The most important factor which could explain this protective effect of GE is its antioxidant activity (Seckiner et al 2014). Garlic is composed of organosulfur compounds such as diallyl trisulfide that Fig.…”

Section: Discussionmentioning

confidence: 95%

Garlic (Allium sativum) exhibits a cardioprotective effect in experimental chronic renal failure rat model by reducing oxidative stress and controlling cardiac Na+/K+-ATPase activity and Ca2+ levels

Gomaa

Abdelhafez

Aamer

2018

Cell Stress and Chaperones

View full text Add to dashboard Cite

Gentamicin (GNT)-induced nephrotoxicity culminates into renal failure with a possible cardiovascular impact. Garlic extract (GE) is a cardiovascular protectant with limited mechanistic data. Therefore, we assessed the disturbance in specific cardiac parameters and the potential protective effect of GE supplementation against them in a rat model of GNT-induced chronic renal failure (CRF). Adult male rats (n = 24) were randomly assigned into four groups (n = 6 each): normal controls (CON), garlic extract controls (GE; 250 mg kg, orally), GNT-induced CRF (GNT; 100 mg kg, i.p.), and GNT + GE (GNT and GE in the same previous doses) groups. GNT and GE were given daily for 3 weeks. Animals co-treated with GNT and GE exhibited improved renal functions, body weight (BW), and heart weight (HW)/BW ratio; declined blood pressure; lowered plasma levels of lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), and total peroxides (TP); and elevated total antioxidant capacity (TAC) levels. Moreover, the heart tissue contained raised levels of TAC and Na/K-ATPase activity and lowered levels of TP and Ca. Findings provide evidence that administration of GE in experimental CRF model helped protect the heart through reducing oxidative stress and controlling cardiac Na/K-ATPase activity and Ca levels.

show abstract

“…It has been suggested that the active substance in garlic may be one of the sulphur compounds; among them, allicin is considered as one of the highest bioactive organosulphur compounds from garlic [12]. Despite the fact that the effect of whole garlic extract on hypertension is well known, the effects of allicin on blood pressure and renal and cardiac function specifically in CKD are scarce [17–19]. Thus, this study was designed to assay the usefulness of allicin in treatment of complications associated with CKD.…”

Section: Discussionmentioning

confidence: 99%

Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease

García-Trejo

Arellano‐Buendía

Argüello-García

et al. 2016

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

This work was performed to study the effect of allicin on hypertension and cardiac function in a rat model of CKD. The groups were control, CKD (5/6 nephrectomy), and CKD-allicin treated (CKDA) (40 mg/kg day/p.o.). Blood pressure was monitored (weekly/6 weeks). The cardiac function, vascular response to angiotensin II, oxidative stress, and heart morphometric parameters were determined. The CKD group showed hypertension and proteinuria. The coronary perfusion and left ventricular pressures were decreased in CKD group. In contrast, the vascular response to angiotensin II and expression of angiotensin II type 1 receptor (AT1R) were increased. These data were associated with the increment in morphometric parameters (weight of heart and left ventricle, heart/BW and left ventricular mass index, and wall thickness). Concurrently, the oxidative stress was increased and correlated inversely with the expression of Nrf2, Keap1, and antioxidant enzymes Nrf2-regulated. Allicin treatment attenuated hypertension and improved the renal and the cardiac dysfunctions; furthermore, it decreased the vascular reactivity to angiotensin II, AT1R overexpression, and preserved morphometric parameters. Allicin also downregulated Keap1 and increased Nrf2 expression, upregulated the antioxidant enzymes, and reduced oxidative stress. In conclusion, allicin showed an antihypertensive, nephroprotective, cardioprotective, and antioxidant effects, likely through downregulation of AT1R and Keap1 expression.

show abstract

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

Cited by 25 publications

References 22 publications

Effect of dimethyl sulfoxide in combat with gentamicin induced nephrotoxicity in rats

Effect of dimethyl sulfoxide in combat with gentamicin induced nephrotoxicity in rats

Garlic (Allium sativum) exhibits a cardioprotective effect in experimental chronic renal failure rat model by reducing oxidative stress and controlling cardiac Na+/K+-ATPase activity and Ca2+ levels

Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease

Contact Info

Product

Resources

About