Oxidative stress and inflammation are connected to the development of metabolic
disorders, such as diabetes. Diabetic-related oxidative stress is caused by the
overproduction of oxidative-free radicals, which have been implicated in the mechanism
of inflammation and damage to tissues. Our study aimed to investigate the effects of
ubiquinone treatment on serum indicators of oxidative stress (malondialdehyde (MDA)),
inflammation (interleukin 6 (IL-6)), vascular homeostasis (nitric oxide (NO)), and
myopathy (myoglobin (MB)) in addition to measuring blood components parameters in
streptozotocin-induced diabetic rats. Rats were separated into three groups; negative
control group (N), diabetic control group (D), and ubiquinone-treated diabetic group
(T). After 21 days, the blood and serum samples were taken to evaluate fasting blood
glucose (FBG), MDA, IL-6, NO, MB, and hematological parameters. In hyperglycemic rats,
the levels of FBG and serum levels of IL-6, MDA, and MB significantly increased, while
NO levels decreased. Hyperglycemic condition significantly lowered the count of WBC (P =
0.0098) but insignificantly decreased values of platelets and RBC. Ubiquinone treatment
significantly reduced blood glucose, IL-6, MDA, and MB levels in diabetic rats and
raised NO levels. The effects of ubiquinone on WBC (P = 0.648), RBC (P = 0.001), and (P
= 0.398) were insignificant, and only minor variations in WBC and platelet levels were
observed. Our data support that ubiquinone supplementation could reduce proinflammation,
oxidative stress, and myopathy markers and elevate NO levels in diabetic rats. The
current study indicates ubiquinone may positively impact diabetic complications;
however, additional research is required to determine its therapeutic benefit when added
to standard diabetes treatment.