Serum interleukin -8 is not a reliable marker for prediction of vesicoureteral reflux in children with febrile urinary tract infection

Abstract

Objective:In view of the side effects of voiding cystourethrography (VCUG), identification of noninvasive markers predicting the presence of vesicoureteral reflux (VUR) is important. This study was conducted to determine the predictive value of serum interleukin-8 (IL-8) in diagnosis of VUR in children with first febrile urinary tract infection (UTI).Materials and Methods:Eighty children with first febrile UTI were divided into two groups, with and without VUR, based on the results of VCUG. The sensitivity, specificity, positive and negative predictive value positive and negative likelihood ratio, and accuracy of IL-8 for prediction of VUR were investigated.Results:Of the 80 children with febrile UTI, 30 (37.5%) had VUR. There was no significant difference between the children with and without VUR and also between low and high-grade VUR groups in terms of serum concentration of IL-8 (P>0.05). Based on ROC curve, the sensitivity, specificity, likelihood ratio positive, and accuracy of serum IL-8 was lower than those of erythrocyte sedimentation rate and C-reactive protein. Multivariate logistic regression analysis showed significant positive correlation only between erythrocyte sedimentation rate and VUR.Conclusions:This study showed no significant difference between the children with and without VUR in terms of the serum concentration of IL-8. Therefore, it seems that serum IL-8 is not a reliable marker for prediction of VUR.

The urinary and serum levels of IL-32 in children with febrile urinary tract infections

“…There was neither a significant difference between the children with and without VUR, nor between low- and high-grade VUR groups regarding serum concentration of IL-8 (p > 0.05). Based on an ROC curve, the sensitivity, specificity, likelihood ratio and accuracy of serum IL-8 were lower than those of erythrocyte sedimentation rate and C-reactive protein [ 32 ]. Similarly, the serum level of IL-32 was similar between the three groups of patients in our study.…”

Imaging studies and biomarkers to detect clinically meaningful vesicoureteral reflux

“…Urinary substances are of particular interest as the collection method is noninvasive. However, an entire review article could be devoted to urinary biochemical markers that have not reliably demonstrated clinical validity or studies that provide conflicting evidence [ 53 54 55 56 ]. Serum procalcitonin is an excellent example of this phenomenon [ 57 ].…”