Intervention effect and mechanism of curcumin in chronic urinary tract infection in rats

Xue, Wenyong; Qi, Ji; Du, Lei

doi:10.1016/j.apjtm.2017.06.009

Cited by 10 publications

(6 citation statements)

References 24 publications

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“…Hence, there has been a growing interest in identifying and developing novel antimicrobial compounds from a variety of sources to tackle microbial resistance [ 43 ]. Herbal medicines such as turmeric and its bioactive molecule curcumin, have been shown to improve the symptoms of chronic UTIs, protect renal tubular function, and reduce inflammatory responses [ 44 , 45 ]. Herbal remedies have been demonstrated to be effective in the treatment of UTIs [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Potential of Bacopa monnieri (L.) Wettst. and Its Bioactive Molecules against Uropathogens—An In Silico Study to Identify Potential Lead Molecule(s) for the Development of New Drugs to Treat Urinary Tract Infections

et al. 2022

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Urinary tract infections (UTIs) are becoming more common, requiring extensive protection from antimicrobials. The global expansion of multi-drug resistance uropathogens in the past decade emphasizes the necessity of newer antibiotic treatments and prevention strategies for UTIs. Medicinal plants have wide therapeutic applications in both the prevention and management of many ailments. Bacopa monnieri is a medicinal plant that is found in the warmer and wetlands regions of the world. It has been used in Ayurvedic systems for centuries. The present study aimed to investigate the antibacterial potential of the extract of B. monnieri leaves and its bioactive molecules against UTIs that are caused by Klebsiella pneumoniae and Proteus mirabilis. This in vitro experimental study was conducted by an agar well diffusion method to evaluate the antimicrobial effect of 80% methanol, 96% ethanol, and aqueous extracts of B. monnieri leaves on uropathogens. Then, further screening of their phytochemicals was carried out using standard methods. To validate the bioactive molecules and the microbe interactions, AutoDock Vina software was used for molecular docking with the Klebsiella pneumoniae fosfomycin resistance protein (5WEW) and the Zn-dependent receptor-binding domain of Proteus mirabilis MR/P fimbrial adhesin MrpH (6Y4F). Toxicity prediction and drug likeness were predicted using ProTox-II and Molinspiration, respectively. A molecular dynamics (MD) simulation was carried out to study the protein ligand complexes. The methanolic leaves extract of B. monnieri revealed a 22.3 mm ± 0.6 mm to 25.0 mm ± 0.5 mm inhibition zone, while ethanolic extract seemed to produce 19.3 mm ± 0.8 mm to 23.0 mm ± 0.4 mm inhibition zones against K. pneumoniae with the use of increasing concentrations. In the case of P. mirabilis activity, the methanolic extracts showed a 21.0 mm ± 0.8 mm to 24.0 mm ± 0.6 mm zone of inhibition and the ethanol extract produced a 17.0 mm ± 0.9 mm to 23.0 mm ± 0.7 mm inhibition zone with increasing concentrations. Carbohydrates, flavonoids, saponin, phenolic, and terpenoid were common phytoconstituents identified in B. monnieri extracts. Oroxindin showed the best interactions with the binding energies with 5WEW and 6Y4F, −7.8 kcal/mol and −7.6 kcal/mol, respectively. Oroxindin, a bioactive molecule, followed Lipinski’s rule of five and exhibited stability in the MD simulation. The overall results suggest that Oroxindin from B. monnieri can be a potent inhibitor for the effective killing of K. pneumoniae and P. mirabilis. Additionally, its safety has been established, indicating its potential for future drug discovery and development in the treatment for UTIs.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Potential of Bacopa monnieri (L.) Wettst. and Its Bioactive Molecules against Uropathogens—An In Silico Study to Identify Potential Lead Molecule(s) for the Development of New Drugs to Treat Urinary Tract Infections

et al. 2022

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“…Studies have reported that many inflammatory cytokines are highly expressed in the serum of patients with chronic inflammatory infectious disease (Chaudhry et al, 2014;Morozov et al, 2016). Curcumin inhibits the messenger RNA (mRNA) expression of TLR2 and TLR4 and reduces the over-release of inflammatory mediators, which lead to the attenuation of the inflammatory response in rats with chronic urinary tract infections (Xue, Qi, & Du, 2017).…”

Section: Urinary Tract Infectionmentioning

confidence: 99%

Impact of curcumin on toll‐like receptors

Boozari

Butler²,

Sahebkar

2019

Journal Cellular Physiology

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Toll‐like receptors (TLRs) have a pivotal role in the activation of innate immune response and inflammation. TLRs can be divided into two subgroups including extracellular TLRs that recognize microbial membrane components (TLR1, 2, 4, 5, 6, and 10), and intracellular TLRs that recognize microbial nucleic acids (TLR3, 7, 8, and 9). Curcumin is a dietary polyphenol from Curcuma longa L. that is reputed to have diverse biological and pharmacological effects. Extensive research has defined the molecular mechanisms through which curcumin mediates its therapeutic effects. One newly defined and important target of curcumin is the TLR, where it exerts an inhibitory effect. In the current study, we focus upon the TLR antagonistic effect of curcumin and curcumin's therapeutic effect as mediated via TLR inhibition. The available evidence indicates that curcumin inhibits the extracellular TLR 2 and 4 and intracellular TLR9 and thereby exerts a therapeutic effect in diseases such as cancer, inflammation, infection, autoimmune, and ischemic disease. Curcumin effectively modulates the TLR response and thereby exerts its potent therapeutic effects.

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“…Furthermore, the patient living in Reunion Island and reported to consume curcumin which has been implicated in “improving the symptoms of chronic urinary tract infections, protect renal tubular function, and also decline inflammatory responses by influencing the expressions of TLR2 mRNA and TLR4 mRNA so as to exert its curative effect on chronic urinary tract infections” [ 7 ]…”

Section: Discussionmentioning

confidence: 99%

Acute pyelonephritis revealing an intraprostatic obstructive megaureter in an adult: A rare finding

Kassir

Ngamba

Michel

et al. 2018

International Journal of Surgery Case Reports

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HighlightsDuplicated renal collecting system is one of the most common congenital upper urinary tract abnormalities.Estimated prevalence ranges between 0.3–6% in the general population.Duplex system with ectopic obstructive megaureter in the prostatic urethra is rare and exceptionally revealed in adulthood.Although considered an anatomical variant, duplex collecting system may be complicated by vesicoureteral reflux, ureterocele, or ectopic ureter.In case of complicated duplex collecting, the surgical treatment may include upper pole nephrectomy or total nephrectomy. For pediatric patients, nephron-saving surgery is recommended.Early diagnosis and treatment of complicated duplex system is important.

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Intervention effect and mechanism of curcumin in chronic urinary tract infection in rats

Abstract: Curcumin can significantly improve the symptoms of chronic urinary tract infections, protect renal tubular function, and also decline inflammatory responses by influencing the expressions of TLR2 mRNA and TLR4 mRNA so as to exert its curative effect on chronic urinary tract infections.

Cited by 10 publications

References 24 publications

Antibacterial Potential of Bacopa monnieri (L.) Wettst. and Its Bioactive Molecules against Uropathogens—An In Silico Study to Identify Potential Lead Molecule(s) for the Development of New Drugs to Treat Urinary Tract Infections

Antibacterial Potential of Bacopa monnieri (L.) Wettst. and Its Bioactive Molecules against Uropathogens—An In Silico Study to Identify Potential Lead Molecule(s) for the Development of New Drugs to Treat Urinary Tract Infections

Impact of curcumin on toll‐like receptors

Acute pyelonephritis revealing an intraprostatic obstructive megaureter in an adult: A rare finding

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