Necessidade de novos antibióticos

Brito, Monique Araújo de; Cordeiro, Benedito Carlos

doi:10.1590/s1676-24442012000400002

Cited by 12 publications

(10 citation statements)

References 12 publications

(15 reference statements)

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“…In some places of the world, including Brazil, there are bacteria resistant to all antimicrobials. Nevertheless, some studies show that the intake of antimicrobials, and consequently resistance to them, have decreased because health authorities have controlled the use of these medications (4) . Many of these studies did not analyze data using statistical tools, what does not reveal the actual variation in indices of microbial resistance.…”

Section: Discussionmentioning

confidence: 99%

Urinary infection in patients of public health care of Campo Mourão-PR, Brazil: bacterial prevalence and sensitivity profile

Bitencourt

Pavanelli

2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

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Introduction: Cases of bacterial resistance in urinary tract infections (UTIs) have increased significantly, mainly due to indiscriminate use of antimicrobials. Objective: To evaluate the prevalence and antimicrobial susceptibility of microorganisms isolated in urine cultures of patients of Consórcio Intermunicipal de Saúde da Comunidade dos Municípios da Região de Campo Mourão (CIS-COMCAM) clinical laboratory. Method: We performed a retrospective study of data from urine culture and sensitivity done between January 2012 and December 2013. Results: The most prevalent bacteria were Escherichia coli; women were the most affected gender and people 16-45 years, the most affected age group. The sensitivity profile showed that the antimicrobial combination trimethoprim/ sulfamethoxazole was not associated with the highest rate of bacterial resistance (59.7%) and the combination of amoxicillin/clavulanic acid showed the lowest resistance rate (15.3%). For most antimicrobials, including ciprofloxacin and norfloxacin, the rates of bacterial resistance have increased from 2012 to 2013 with statistical significance (p < 0.05) in some cases. Discussion: The prevalence of Gram-negative bacilli in urinary infections is due to the fact that intestinal flora is rich in enterobacteria, and women are most affected by anatomical factors. The development of bacterial resistance to antimicrobials probably arises from their indiscriminate use. Conclusion: The rate of microbial resistance has risen, showing the need for a more effective control of antimicrobial use.

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Section: Discussionmentioning

confidence: 99%

Urinary infection in patients of public health care of Campo Mourão-PR, Brazil: bacterial prevalence and sensitivity profile

Bitencourt

Pavanelli

2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

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“…Emplea microorganismos, como fagos, levaduras, bacterias y virus, para mostrar repertorios de fragmentos de anticuerpos de dominio variable (ScFvs) de una sola cadena, fragmentos de unión a antígenos (Fab) o anticuerpos de dominio (Dabs) en sus superficies (188), lo que genera inversión importante para la identificación de nuevos y mejores fármacos con exploración de biofactorías con microorganismos como E. coli y S. cerevisiae (189).…”

Section: Carácterísticas Bibliografíaunclassified

Aplicaciones biotecnológicas de los microorganismos

Ostos-Ortíz

Rosas-Arango

González-Devia

2019

nova

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La biodiversidad de los microorganismos así como la naturaleza única y las capacidades biosintéticas en condiciones ambientales específicas hacen que los microorganismos sean los probables candidatos para resolver problemas de escases de alimentos, contro de plagas, biodegradación de los xenobióticos, descomposición de la basura, las pilas de desechos producidas, entre otros. Los microorganismos ofrecen un gran potencial para la exploración de moléculas y procesos, y el conocimiento de las especies no convencionales, especialmente dentro del grupo Archaea, ha estimulado la investigación molecular de genes de interés. Estos nuevos genes pueden incorporarse mediante tecnología recombinante en especies biológicamente conocidas, como E. coli y S. cerevisiae, para la síntesis a gran escala de productos. La microbiología tecnológica tiene grandes potenciales para explorar y obstáculos por superar. Por lo tanto, solo la investigación en esta área resulta prometedora para científicos en todo el mundo. En la presente revisión se presentan las aplicaciones más significativas de los microorganismos en la industria de alimentos, la agricultura, compuestos químicos, combustibles, farmacología y materiales.

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“…The boom of antibiotic discovery occurred between 1950 and 1960. However, despite the need for new antibiotics, only two new classes of antibiotics have been introduced in medicine since 1963, both of which are based on nalidixic acid (Brito and Cordeiro, 2012). Limited research results, inappropriate prescription of antibiotics, and misuse of antibiotics by the general population have threatened antibiotic potency and increased the occurrence of superbugs, i.e., microorganisms that appear at an alarming rate and are resistant to most or all clinical antibiotics in use (Srivastava et al, 2011).…”

Section: Medical Technological Microbiologymentioning

confidence: 99%

Technological Microbiology: Development and Applications

Vitorino

Bessa

2017

Front. Microbiol.

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Over thousands of years, modernization could be predicted for the use of microorganisms in the production of foods and beverages. However, the current accelerated pace of new food production is due to the rapid incorporation of biotechnological techniques that allow the rapid identification of new molecules and microorganisms or even the genetic improvement of known species. At no other time in history have microorganisms been so present in areas such as agriculture and medicine, except as recognized villains. Currently, however, beneficial microorganisms such as plant growth promoters and phytopathogen controllers are required by various agricultural crops, and many species are being used as biofactories of important pharmacological molecules. The use of biofactories does not end there: microorganisms have been explored for the synthesis of diverse chemicals, fuel molecules, and industrial polymers, and strains environmentally important due to their biodecomposing or biosorption capacity have gained interest in research laboratories and in industrial activities. We call this new microbiology Technological Microbiology, and we believe that complex techniques, such as heterologous expression and metabolic engineering, can be increasingly incorporated into this applied science, allowing the generation of new and improved products and services.

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Necessidade de novos antibióticos

Cited by 12 publications

References 12 publications

Urinary infection in patients of public health care of Campo Mourão-PR, Brazil: bacterial prevalence and sensitivity profile

Urinary infection in patients of public health care of Campo Mourão-PR, Brazil: bacterial prevalence and sensitivity profile

Aplicaciones biotecnológicas de los microorganismos

Technological Microbiology: Development and Applications

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