Expressão de galectina-3 e citoqueratina 19 nas neoplasias epiteliais da glândula tireóidea e correlação histopatológica

Rosa, Marilene Paladino; Kanamura, Cristina Takami; Carvalho, Marcos Brasilino de

doi:10.1590/s1676-24442005000100012

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“…Existem três padrões histológicos diferentes para essa neoplasia: cribriforme, tubular e sólido (YAMAMOTO et al, 1998), entretanto, as células tumorais que a compõem são principalmente de dois tipos: células luminais e células mioepiteliais (BARNES et al, 2005;FURUSE et al, 2005 (WILSON et al, 1986;FERNANDEZ et al, 1997;ROSA;KANAMURA;CARVALHO, 2005).…”

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"Expressão imunoistoquímica da proteína galectina-3 em carcinoma adenóide cístico e adenocarcinoma polimorfo de baixo grau de malignidade de glândulas salivares"

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"Expressão imunoistoquímica da proteína galectina-3 em carcinoma adenóide cístico e adenocarcinoma polimorfo de baixo grau de malignidade de glândulas salivares"

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“…Os estudos da galectina-3 em tecidos tireoideanos normais e neoplásicos demonstraram que a galectina-3 tem se mostrado ausente ou com uma fraca expressão em tecidos normais e neoplasias benignas da tireóide, e superexpressa em carcinomas tireoideanos, principalmente nos carcinomas papilíferos (FERNANDEZ et al, 1997;ROSA;KANAMURA;CARVALHO, 2005;WILSON et al, 1986).…”

Section: Galectina-3unclassified

Estudo da expressão imunoistoquímica da proteína galectina-3 associada à -catenina e ciclina D1 em carcinoma adenóide cístico e adenocarcinoma polimorfo de baixo grau de malignidade de glândulas salivares

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Salivary gland tumors are uncommon and the mechanism by which malignant tumors progresses is still undefined. In a previous study it was shown that galectin-3 is expressed in malignant salivary gland neoplasms as adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Galectin-3 is a multifunctional protein of a group of galactoside-binding lectins expressed in a variety of normal cells, but also has been implicated in tumor progression of some malignancies as thyroid, prostate and gastric cancers. Recently, it has been suggested that galectin-3 may be an important mediator of the β-catenin/Wnt pathway. Moreover, nuclear galectin-3 expression has been implicated in cell proliferation, promoting cyclin D1 activation. Thus, in the present study we aimed to correlate galectin-3 expression, either nuclear or cytoplasmic, with the expression of β-catenin (nuclear/cytoplasmic) and cyclin D1 (nuclear) in 15 cases of adenoid cystic carcinoma and in 15 cases of polymorphous low-grade adenocarcinoma. For galectin-3, adenoid cystic carcinomas showed specific staining only in luminal cells, mainly in the nuclei. In the cases of polymorphous low-grade adenocarcinoma, all tumor cells revealed a positive, mostly cytoplasmic, reaction to galectin-3. Both tumors showed intense cytoplasmic/nuclear staining for β-catenin in the majority of cases. Cyclin D1 immunoreactivity was not detected in 14 of the 15 polymorphous low-grade adenocarcinomas studied. In contrast, adenoid cystic carcinomas showed specific nuclear staining for cyclin D1 in 10 of 15 cases studied in more than 5% of the neoplastic cells. Cyclin D1 expression was correlated with cytoplasmic and nuclear galectin-3 expression in adenoid cystic carcinomas (p<0,05). These results suggest that in adenoid cystic carcinoma galectin-3 may play a role in cellular proliferation through cyclin D1 activation. In polymorphous low-grade adenocarcinoma gal-3 expression seems to be associated with cellular differentiation. In addition, loss of cytoplasmic expression of galectin-3 in adenoid cystic carcinomas may be related to a more aggressive behavior of these lesions. Although β-catenin seems to play a role in carcinogenesis, in both lesions, it seems that it does not bind to galectin-3 for cyclin D1 stimulation.

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Expressão de galectina-3 e citoqueratina 19 nas neoplasias epiteliais da glândula tireóidea e correlação histopatológica

Cited by 2 publications

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"Expressão imunoistoquímica da proteína galectina-3 em carcinoma adenóide cístico e adenocarcinoma polimorfo de baixo grau de malignidade de glândulas salivares"

"Expressão imunoistoquímica da proteína galectina-3 em carcinoma adenóide cístico e adenocarcinoma polimorfo de baixo grau de malignidade de glândulas salivares"

Estudo da expressão imunoistoquímica da proteína galectina-3 associada à -catenina e ciclina D1 em carcinoma adenóide cístico e adenocarcinoma polimorfo de baixo grau de malignidade de glândulas salivares

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