Evaluation of some pharmacological activities of Budmunchiamine - A isolated from Albizia amara

Abstract

The present investigations were aimed to evaluate the antimicrobial and antioxidant efficacies of budmunchiamine-A (BUA) of Albizia amara . The activity-guided isolation leaded to isolate the bioactive compound budmunchiamine-A from alkaloid extract of A. amara . The budmunchiamine-A showed significant broad-spectrum antimicrobial activity with zone of inhibition (ZOI), minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) values varied from 7.3 to 24.5 mm, 0.95 to 62.5 μg/mL, and 1.9 to 250 μg/mL, respectively. The budmunchiamine-A exhibited moderate antioxidant activity with inhibitory concentration 50% (IC 50 ) value of 400 μg/mL in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and percent inhibition of β-carotene/linoleic acid was 67.8%. The results suggest the possible use of budmunchiamine-A as a molecular entity for drug development in pharmaceutical industry.

Anticholinesterase Activity of Budmunchiamine Alkaloids Revealed by Comparative Chemical Profiling of Two Albizia spp., Molecular Docking and Dynamic Studies

“…Budmunchiamine alkaloids exhibited promising health-promoting activities, such as antioxidant [ 36 ], anti-cancer [ 35 ], antimicrobial [ 35 , 36 , 37 ], and against Alzheimer’s disease [ 38 ]. Furthermore, the potential key role of alkaloids as anticholinesterase phytoconstituents had been previously reviewed [ 39 ].…”

A Review on Phytopharmacological Properties of Arappu

“…20 Thippeswamy et al, (2015) reported the antioxidant activity of the alkaloid, budmunchiamines(BUA) isolated from the leaf extract of A.amara. 18 Raj Kumar et al, (2012) has reported the anti oxidant activity of methanolic extract and petroleum ether extract of Albizia amara leaves. IC 50 value was found to be 205 µg/ml for methanolic extract and 148 µg/ml for petroleum ether extract.…”