The ethnopharmacology, phytochemistry, pharmacology and toxicology of genus Albizia: A review

He, Yi; Wang, Qiaowen; Ye, Yiping; Liu, Zhaoying; Sun, Hongxiang

doi:10.1016/j.jep.2020.112677

Cited by 24 publications

(17 citation statements)

References 107 publications

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“…These findings corroborate well with the clinical signs of toxicity, such as increased respiration, excessive urination, and defecation, and the single mortality registered upon oral administration of A. coriaria extract. These findings also agree with many studies which have reported toxic extracts/compounds from the Genus Albizia [ 65 – 68 ]. This indicates that A. coriaria is moderately toxic at the current dose of 2000 mg/kg.…”

Section: Discussionsupporting

confidence: 93%

Phytochemical screening, antimycobacterial activity and acute toxicity of crude extracts of selected medicinal plant species used locally in the treatment of tuberculosis in Uganda

et al. 2022

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Background Tuberculosis (TB) is one of the leading causes of death globally, and the rise in drug-resistant forms of TB has become a significant threat. Subsequently, it is crucial to explore new, effective and safe anti-TB agents. This study aimed at conducting phytochemical screening, antimycobacterial activity, and acute toxicity of the selected plant species’ crude extracts to assess their toxicological potentials and efficacies against TB. Methods The aqueous and methanol/dichloromethane (DCM) (1:1) extracts of each selected plant species were subjected to phytochemical screening and antimycobacterial activity using microplate alamar blue assay. For acute toxicity, a single dose (2000 mg/kg) of the aqueous extracts was orally administered to each animal following the Organization for Economic Cooperation and Development (OECD) guidelines No. 425 and then observed for 14 days. The animals were closely observed on the general behavior and clinical signs of toxicity, and body weights were recorded. After the termination of the experiment, hematological, biochemical, and histopathological analyses were performed. Results The extracts contained alkaloids, flavonoids, tannins, saponins, steroids, terpenoids, resins, cardiac glycosides, phenolic compounds, and coumarins. Aqueous extracts showed moderate to weak activity against the susceptible (H37Rv) M. tuberculosis strain and weak activity against the MDR-TB strain with Minimum Inhibitory Concentrations (MIC μg/mL) ranging from 293.0–2344.0 and 1172.0–4688.0, respectively. Methanol/DCM extracts showed significant to moderate activity against the susceptible TB strain and moderate to weak activity against the MDR-TB strain with MIC (μg/mL) ranging from 98.0–586.0 and 293.0–781.0, respectively. One mortality was recorded from the A. coriaria treated group following the acute toxicity tests, but the LD50 of all the extracts was estimated to be above 2000 mg/kg. Histopathological analyses did not show any significant lesions in the examined organs except those from the A. coriaria treated group. Conclusion Phytochemical screening of the extracts revealed the presence of alkaloids, tannins, saponins, flavonoids, steroids, terpenoids, resins, cardiac glycosides, phenolic compounds, and coumarins. All the methanol/DCM extracts of the plant species studied have promising antimycobacterial activity. The selected plant extracts studied exhibited low acute toxicity levels except for A. coriaria and could be safe for formulations into herbal products.

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Section: Discussionsupporting

confidence: 93%

Phytochemical screening, antimycobacterial activity and acute toxicity of crude extracts of selected medicinal plant species used locally in the treatment of tuberculosis in Uganda

et al. 2022

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“…Albizia julibrissin , also called mimosa or Persian silktree, is a member of the family Leguminosae. Albizziae cortex (AC), the stem bark of Albizia julibrissin , has been widely used for the treatment of insomnia in traditional Chinese medicine as a sedative and anti-inflammatory agent 33 . It has also been used as a vital composition of clinical anti-tumor prescriptions 34 , 35 , 36 .…”

Section: Discussionmentioning

confidence: 99%

Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer

Qian

Zhao

Han

et al. 2021

Acta Pharmaceutica Sinica B

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Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer cells. Mitochondrial dynamics balance is exactly regulated by molecular motor consisted of myosin and actin cytoskeleton proteins. Thus, targeting myosin–actin molecular motor is considered as a promising strategy for anti-cancer. In this study, we performed a proof-of-concept study with a natural-derived small-molecule J13 to test the feasibility of anti-cancer therapeutics via pharmacologically targeting molecular motor. Here, we found J13 could directly target myosin-9 (MYH9)–actin molecular motor to promote mitochondrial fission progression, and markedly inhibited cancer cells survival, proliferation and migration. Mechanism study revealed that J13 impaired MYH9–actin interaction to inactivate molecular motor, and caused a cytoskeleton-dependent mitochondrial dynamics imbalance. Moreover, stable isotope labeling with amino acids in cell culture (SILAC) technology-coupled with pulldown analysis identified HSPA9 as a crucial adaptor protein connecting MYH9–actin molecular motor to mitochondrial fission. Taken together, we reported the first natural small-molecule directly targeting MYH9–actin molecular motor for anti-cancer translational research. Besides, our study also proved the conceptual practicability of pharmacologically disrupting mitochondrial fission/fusion dynamics in human cancer therapy.

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“…There are no reports in open literature on the compounds in A. coriaria leaves, flowers and seeds though triterpenoid saponins are commonly characterized in the Albizia genus (Note et al, 2010;Note et al, 2009). The triterpenoidal saponins possess aglycon parts which may be oleanolic acid, echinocystic acid, acacic acid lactone or machaerinic acid γ-lactone (Gupta, Chaudhary, Yadav, Verma, & Dobhal, 2005;He, Wang, Ye, Liu, & Sun, 2020;Noté et al, 2015;Singab et al, 2015). The sugar residues are frequently glucose, 2-acetamido-2-deoxy glucose, xylose, rhamnose, fucose or arabinose (Singab et al, 2015).…”

Section: Phytochemistry Of a Coriariamentioning

confidence: 99%

“…The genus Albizia is known for its various pharmacological activities (He et al, 2020;Singab et al, 2015). The species A. coriaria has not been exhaustively investigated for its bioactivities such as antimycobacterial, antivenom and anticancer activities (Byamukama et al, 2015;Obakiro et al, 2020;Omara et al, 2020a;Omara et al, 2020b;Schultz et al, 2021a).…”

Section: Pharmacological Profile Of Albizia Coriariamentioning

confidence: 99%

Albizia coriaria Welw ex Oliver: a review of its ethnobotany, phytochemistry and ethnopharmacology

Omara

Kiprop

Kosgei

2021

ADV TRADIT MED (ADTM)

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Albizia coriaria Welw ex. Oliver have a long history of ethnomedicinal use in the management of various diseases in Africa. Due to the frequent use of its stem bark and roots in traditional phytotherapy, the species is getting threatened in its distributional ranges. The current review was sought to document information on the ethnobotany, phytochemicals and pharmacology of different parts of A. coriaria, so as to highlight the gaps thereof for future studies. Data retrieved revealed that medicinal uses of A. coriaria have been reported for both human and veterinary ailments. Though the bark is the most commonly used, different parts of the plant are used to prepare herbal remedies for treatment of malignancies, odontological, dermatological, respiratory, gastrointestinal, reproductive, central nervous system infections/conditions and ailments. Preliminary phytochemical screening has indicated the presence of saponins, tannins, alkaloids, flavonoids, phenols, terpenes, cardiac glycosides and steroids as the major secondary metabolites in the stem bark and leaves. Like for other Albizia species, at least six triterpenoidal saponins have been characterized in organic extracts of A. coriaria stem bark and roots. Extracts and some pure compounds from A. coriaria stem bark, leaves and roots have exhibited antiproliferative (cytotoxic), antiplasmodial, molluscicidal, antigiardial, antioxidant, anti-inflammatory and antimicrobial activities. Further research should evaluate pharmacological properties such as antisnake venom, aphrodisiac, antiviral and antimycobacterial activities of the different parts of A. coriaria claimed in traditional folklore. In-depth studies on the pharmacokinetics, in vivo and clinical research utilizing extracts and isolated compounds from A. coriaria are required.

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The ethnopharmacology, phytochemistry, pharmacology and toxicology of genus Albizia: A review

Cited by 24 publications

References 107 publications

Phytochemical screening, antimycobacterial activity and acute toxicity of crude extracts of selected medicinal plant species used locally in the treatment of tuberculosis in Uganda

Phytochemical screening, antimycobacterial activity and acute toxicity of crude extracts of selected medicinal plant species used locally in the treatment of tuberculosis in Uganda

Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer

Albizia coriaria Welw ex Oliver: a review of its ethnobotany, phytochemistry and ethnopharmacology

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