Antibacterial, antifungal and cytotoxic activities of eight Asteraceae and two Rubiaceae plants from colombian biodiversity

Niño, Jaime; Narvaez, Diana Marcela Devia; Mosquera, Oscar M.; Correa, Yaned M.

doi:10.1590/s1517-83822006000400030

Cited by 43 publications

(28 citation statements)

References 23 publications

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“…and are major burning global issues in treating infectious diseases [4]. Although pharmacological industries had produced considerable number of commercial antibiotics time to time but resistance in pathogens towards these drugs too has increased at high rate and mult-drug resistant microorganisms have exacerbated the situation [5]. In the present scenario, there is an urgent and continuous need of exploration and development of cheaper, effective new plant based drugs with better bioactive potential and least side effects.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antifungal Activities of Jatropha multifida (Ogege) Sap against Some Pathogens

Aransiola¹,

Ehikhase²,

Mmegwa³

et al. 2014

IOSRJPBS

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Section: Introductionmentioning

confidence: 99%

Antibacterial and Antifungal Activities of Jatropha multifida (Ogege) Sap against Some Pathogens

Aransiola¹,

Ehikhase²,

Mmegwa³

et al. 2014

IOSRJPBS

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“…Pharmacological evaluation of plants provides a good source for the development of novel and safe medicinal plants. The brine shrimp lethality bioassay has been established as a safe, practical and economic method for the determination of the toxicity of synthetic compounds [26] as well as higher plant products [27]. The brine shrimp nauplii has been used for a number of bioassay systems in which natural product extracts, fractions or pure isolates are tested at various concentrations [17].…”

Section: Discussionmentioning

confidence: 99%

Preliminary phytochemical screening and cytotoxic potentials from leaves of Sanchezia speciosa Hook.f

Parvin

Rafshanjani

Kader

et al. 2015

Int J of Adv in Sci Res

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Background: Sanchezia speciosa Hook.f is an important medicinal plant with several ethnomedicinal properties. In the present experiment the leaves of this plant were screened for the presence of major phytochemical groups. The phytochemicals are the wide variety of compounds produced by plants manipulated widely in the pharmacognostic drug development and in the treatment of the major ailments. Methods: Phytochemical screenings were performed by various functional group tests. All the leaves extracts were subjected to brine shrimp lethality bioassay and standard anticancer drug vincristine sulphate was used as positive control. Results: Phytochemical investigation of the leaves extracts showed the presence of alkaloids, glycosides, flavonoids, triterpenoids, carbohydrates, steroids, phenolic compounds, saponins and tannins. The ethyl acetate fractionates of the leaves extracts were positive for all the phytochemicals tested while n-hexane fractionates were negative for flavonoids and phenolic compounds. The n-hexane and ethyl acetate soluble fractionates showed significant cytotoxic activities with median lethal concentrations (LC 50 ) 19.95 µg/mL and 12.88µg/mL while LC 50 for the vincristine sulphate was 10.96 µg/mL. Conclusion: This study shows that the leaves of Sanchezia speciosa Hook. f may have potentials in control of carcinogenesis in the field of pharmacology.

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“…O teste de toxicidade sobre a Artemia salina (TAS) é um ensaio biológico amplamente utilizado devido ser rápido, confiável, de baixo custo e por ter demonstrado uma boa correlação com várias atividades biológicas (Meyer et al, 1982), como atividade antitumoral (McLaughlin, 1991;McLaughlin et al, 1991McLaughlin et al, , 1993, atividade contra o Trypanosoma cruzi (Dolabela, 1997), atividade antibacteriana (Brasileiro et al, 2006;Niño et al, 2006;Magalhães et al, 2007), antifúngico (Niño et al, 2006;Magalhães et al, 2007). Em geral, extratos com alta toxicidade para Artemia salina (DL 50 < 200 µg/mL) apresentam alto potencial para estas atividades.…”

Section: Discussionunclassified

Estudos farmacognósticos, fitoquímicos, atividade antiplasmódica e toxicidade em Artemia salina de extrato etanólico de folhas de Montrichardia linifera (Arruda) Schott, Araceae

Costa¹,

Dolabela²,

Póvoa³

et al. 2009

Rev. bras. farmacogn.

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RESUMO:O presente trabalho descreve os resultados do estudo farmacognóstico, estudo fitoquímico preliminar, toxicidade em Artemia salina e atividade antiplasmódica contra cepa de Plasmodium falciparum resistente a cloroquina (W2) do extrato etanólico obtido do pó das folhas de Montrichardia linifera (Arruda) Schott, Araceae. Para realização dos estudos farmacognósticos utilizou-se as metodologias descritas na Farmacopéia Brasileira. A prospecção fitoquímica foi realizada pelos métodos descritos por Mattos. No ensaio antiplasmódico foi utilizado o microteste tradicional e no ensaio de Artemia salina. Os resultados obtidos nos estudos farmacognósticos do pó das folhas de M. linifera demonstraram tratar-se de um pó moderadamente grosso, com teores de água e cinzas totais dentro dos limites aceitáveis, baixa densidade (0,324 e 0,339 g/ mL), pH próximo de neutro (6,69±0,02). A análise fitoquímica preliminar evidenciou a presença de alcaloides, flavonoides, taninos, triterpenos e esteroides. O extrato etanólico das folhas de M. linifera apresentou moderada atividade antiplasmódica e baixa toxicidade para a Artemia salina. Unitermos:Montrichardia linifera, estudos farmacognósticos, atividade antiplasmódica, toxicidade, Artemia salina.ABSTRACT: "Pharmacognostics studies, phytochemicals, antiplasmodic activity and toxicity in Artemia salina of ethanolic extract from Montrichardia linifera (Arruda) Schott, Araceae leaves". The present paper describes results of a pharmacognostic, a preliminary phytochemical study, brine shrimp toxicity and antiplasmodic activity in a strain of Plasmodium falciparum that is resistant to chloroquine (W2) using ethanolic extract obtained from powder of the leaves of Montrichardia linifera (Arruda) Schott, Araceae. To perform the pharmacognostic studies methodologies employed in the Brazilian Pharmacopoea were utilized. The methods described by Mattos were utilized for phytochemical prospecting. In the antiplasmodic test the traditional microtest was employed, as well as in the test with brine shrimp. The results obtained in the pharmacognostic studies with the powder from M. linifera leaves showed that it was a moderate thick powder, with water and ash totals within acceptable limits, low density (0.324 and 0.339 g/ mL), pH close to neutral (6.69 ± 0.02). Preliminary phytochemical analysis showed the presence of alkaloids, flavonoids, tannins, triterpenes and esters. The ethanolic extract from M. linifera leaves presented moderate antiplasmodic activity and low brine shrimp toxicity. To summarize, the powder used in preparing the extract presented good quality in pharmacognostic terms.

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Antibacterial, antifungal and cytotoxic activities of eight Asteraceae and two Rubiaceae plants from colombian biodiversity

Cited by 43 publications

References 23 publications

Antibacterial and Antifungal Activities of Jatropha multifida (Ogege) Sap against Some Pathogens

Antibacterial and Antifungal Activities of Jatropha multifida (Ogege) Sap against Some Pathogens

Preliminary phytochemical screening and cytotoxic potentials from leaves of Sanchezia speciosa Hook.f

Estudos farmacognósticos, fitoquímicos, atividade antiplasmódica e toxicidade em Artemia salina de extrato etanólico de folhas de Montrichardia linifera (Arruda) Schott, Araceae

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