Preliminary phytochemical screening and cytotoxic potentials from leaves of Sanchezia speciosa Hook.f

Abstract

Background: Sanchezia speciosa Hook.f is an important medicinal plant with several ethnomedicinal properties. In the present experiment the leaves of this plant were screened for the presence of major phytochemical groups. The phytochemicals are the wide variety of compounds produced by plants manipulated widely in the pharmacognostic drug development and in the treatment of the major ailments. Methods: Phytochemical screenings were performed by various functional group tests. All the leaves extracts were subjected to brine shrimp lethality bioassay and standard anticancer drug vincristine sulphate was used as positive control. Results: Phytochemical investigation of the leaves extracts showed the presence of alkaloids, glycosides, flavonoids, triterpenoids, carbohydrates, steroids, phenolic compounds, saponins and tannins. The ethyl acetate fractionates of the leaves extracts were positive for all the phytochemicals tested while n-hexane fractionates were negative for flavonoids and phenolic compounds. The n-hexane and ethyl acetate soluble fractionates showed significant cytotoxic activities with median lethal concentrations (LC 50 ) 19.95 µg/mL and 12.88µg/mL while LC 50 for the vincristine sulphate was 10.96 µg/mL. Conclusion: This study shows that the leaves of Sanchezia speciosa Hook. f may have potentials in control of carcinogenesis in the field of pharmacology.

Bui Thi Xuan1*, Vu Duc Loi1, Một số hợp chất phân lập từ lá cây Khôi đốm (Sanchezia nobilis Hook.f.)

“…Trên thế giới cây này đã được nghiên cứu về tác dụng chống oxy hóa và chống tăng sinh tế bào in vitro, tác dụng kháng khuẩn [5][6]. Về thành phần hóa học của loài cây này mới có một số công bố cho thấy, cây có chứa một số nhóm chất như: flavonoid, glycosid, carbohydrat, alcaloid, steroid, phenolic, saponin và tannin [7]. Ở Việt Nam, dân gian ta đã truyền nhau sử dụng cây Khôi đốm như một ''vị cứu tinh" chữa bệnh viêm dạ dày.…”

GC-MS and HPLC-ESI-MS-MS Characterization of Sanchezia oblonga (Acanthaceae) Extracts

“…S. speciosa contains cardiac and flavonoid glycosides and their extracts exhibited antioxidant and anti-inflammatory activities (Bui Thanh et al, 2017). Extracts of the same species exerted cytotoxicity in human epithelial cervical cancer cell lines (Shaheen et al, 2017, Parvin et al, 2015.…”

Chemical Constituents and Antiulcer Activity of n-Hexane Extract of Sanchezia nobilis Hook F. Leaves from Vietnam

“…Some specific substances were isolated as five matsutake alcohol compounds, four compounds were isolated for the first time from the family Acathanceae and one another compound was isolated from a nature sources [3,8,9]. Ellah et al [10] isolated six compounds from the methanol extracts of leaves and roots of Sanchezia nobilis.…”