Estudo dos fatores impregnação e secagem nas características de glóbulos utilizados em homeopatia

Diehl, Eliana Elisabeth; Sonaglio, Diva; Lima, Nayla Ferreira; Backes, Sinara

doi:10.1590/s1516-93322008000100016

Cited by 2 publications

(9 citation statements)

References 1 publication

(1 reference statement)

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“…This study gives continuity to that published by Diehl et al (2008), who analyzed the responses of mass difference and disintegration time for the impregnation of inert globules No. 7, which was the dosage form most commonly employed at that time in Florianópolis, Santa Catarina State, Brazil.…”

Section: Resultssupporting

confidence: 85%

“…The choice of 96% hydrated ethanol obtained from cereals for the preparation of the dye solution at 1% was based on a study by Fontes et al (2002), who showed that with the use of a solution with higher alcohol content a mass gain occurs in almost all of the impregnations, whereas on using a hydroalcoholic solution at 70% the opposite behavior is observed. This value differed from that of Diehl et al (2008), who opted for 70%.…”

Section: Resultscontrasting

confidence: 60%

“…The selection of the factors analyzed in the designs was based on data available in the literature (Brazilian Homeopathic Pharmacopeia and Manual of Technical Norms for Homeopathic Pharmacy), on current practices in homeopathic pharmacies in Florianópolis and also on a study previously carried out by Diehl et al (2008).…”

Section: Resultsmentioning

confidence: 99%

“…The impregnation of the inert globules was carried out using the method of triple impregnation only, defined by Diehl et al (2008), which was considered to be the most appropriate despite requiring additional preparation time. Furthermore, even simple impregnation is not a commonly performed activity in homeopathic pharmacies in the municipality of Florianópolis, Santa Catarina State, Brazil.…”

Section: Preparation Of Globulesmentioning

confidence: 99%

“…Furthermore, even though studies on the validation of methods for globule impregnation have been published (Rocha et al, 2000;Gutierrez, 2001;Fontes et al, 2002;Pozetti, Silva, Pizzolitto, 2002;Sartori et al, 2003;Araújo et al, 2004;Pinheiro, 2006;Diehl et al, 2008), the results reported are still not sufficient to verify the most adequate method for application in homeopathic pharmacies in the preparation of this form of medication.…”

Section: Globulesmentioning

confidence: 99%

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Study of the variables which influence the impregnation of globules, compressed tablets and tablet triturates used in homeopathy

Souza

Pirolli

Diehl

et al. 2012

Braz. J. Pharm. Sci.

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Globules, compressed tablets and tablet triturates are solid dosage forms used in homeopathy. Divergences can be noted between the preparation techniques described in official compendiums as well as those applied in homeopathic pharmacies. The difficulty associated with standardization of the impregnation of these dosage forms occurs due to the lack of detail provided for the techniques in the literature, leaving it up to each pharmacy to decide on the exact method of preparation. The objective was to optimize the impregnation technique, through investigating the variables that influence the impregnation of globules, compressed tablets and tablet triturates, applying the statistical tool of factorial design. The independent variables were the dosage form, percentage and type of impregnation and drying temperature, and the dependent variables were the mass gain, disintegration time, friability and hardness. For the globules, the greatest mass gain was for 10% impregnation and drying at 20 °C. For the tablet triturates and compressed tablets the greatest mass gain was for 15% impregnation and there was no difference between the results obtained using simple and triple impregnation or different drying temperatures. The results can contribute to improving the final product quality, besides aiding in the establishment of standardized techniques for the official compendiums.Uniterms: Homeopathic pharmacotechniques. Homeopathic vehicles. Homeopathy/impregnation methods. Homeopathy/globules. Homeopathy/tablet triturates. Homeopathy/compressed tablets.Glóbulos, comprimidos e tabletes são formas farmacêuticas sólidas utilizadas em homeopatia. Constatamse divergências entre técnicas de preparação descritas nos compêndios oficiais, bem como em farmácias homeopáticas. A dificuldade de padronização na impregnação destas formas farmacêuticas também ocorre devido à falta de detalhamento das técnicas na literatura existente, deixando para cada farmácia a escolha de como executá-las. O objetivo foi otimizar a técnica de impregnação, através do estudo de variáveis que interferem na impregnação de glóbulos, comprimidos e tabletes, aplicando como ferramenta estatística planejamento fatorial. As variáveis foram forma farmacêutica, percentual e tipo de impregnação e temperatura de secagem, sendo o ganho de massa, tempo de desintegração, friabilidade e dureza as variáveis dependentes. Para os glóbulos, observou-se maior ganho de massa quando impregnados a 10% e secagem realizada a 20 °C. Para os tabletes e comprimidos, constatou-se maior ganho de massa quando impregnados a 15%, sendo que não houve diferença na impregnação simples ou tríplice nem nas diferentes temperaturas de secagem. Os resultados obtidos podem contribuir para a melhoria da qualidade do produto final, além de auxiliar no estabelecimento de técnicas padronizadas para os compêndios oficiais.Unitermos: Farmacotécnica homeopática. Veículos homeopáticos. Homeopatia/métodos de embebição. Homeopatia/glóbulos. Homeopatia/tabletes. Homeopatia/comprimidos.

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Section: Resultssupporting

confidence: 85%

Section: Resultscontrasting

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Section: Preparation Of Globulesmentioning

confidence: 99%

Section: Globulesmentioning

confidence: 99%

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Study of the variables which influence the impregnation of globules, compressed tablets and tablet triturates used in homeopathy

Souza

Pirolli

Diehl

et al. 2012

Braz. J. Pharm. Sci.

Self Cite

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Validation of impregnation process for homeopathic globules by spectrophotometric-UV method

Pinheiro

Aguiar

Holandino

et al. 2014

Braz. J. Pharm. Sci.

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We compared the impregnation techniques for globules according to the Manual of Technical Norms for Homeopathic Pharmacies (MNTFH) of the Association of Homeopathic Pharmacists (ABFH), Brazilian Homeopathic Pharmacopoeia (FHB) and variations of these techniques. The variables were evaluated in this procedure, three different sizes of globules (N o . 3, 5 and 7), the hydroalcoholic solution of 70% (v/v) Minoxidil 2% (w/v) was used to impregnate the globules in concentrations of 2, 3, 4, 5% (v/w) and the impregnation at 10 %(v/w) was used hydroalcoholic solutions at 70, 80 and 90% (v/v), and four impregnation techniques various (A-glass, B-paper, C-cup and D-FHB). As the results of content uniformity did not demonstrate a normal distribution, the one way ANOVA and a nonparametric statistical model were used for evaluation. Considering the average, the standard deviation (SD), the individual variance of each group and the principal components analysis graphs (PCA), it was observed that the "A" impregnation of globules technique, with 5% (v/w) of the impregnation concentrations and the No.5 globule presented the best uniformity of dose. As to the drying, there was a need to use a heat source.Uniterms: Homeopathic globules/impregnation process. Homeopathic compounding/evaluation. Homeopathic dose/uniformity of content.Compararam-se as técnicas de impregnação para glóbulos segundo o Manual de Normas Técnicas para Farmácias Homeopáticas (MNTFH) da Associação Brasileira de Farmacêuticos Homeopatas (ABFH), Farmacopeia Homeopática Brasileira (FHB) e variações destas técnicas. As variáveis avaliadas neste processo foram: três tamanhos diferentes de glóbulos (n.º 3, 5 e 7); a solução hidroalcóolica a 70% (v/v) de minoxidil a 2% (p/v) foi utilizada para impregnar os glóbulos nas concentrações de 2, 3, 4, 5% (v/p) e na impregnação a 10% (v/p) utilizaram-se as soluções hidroalcóolicas a 70, 80 e 90% (v/v); e quatro técnicas de impregnação diferentes (A-vidro, B-papel, C-copo e D-FHB). A impregnação foi validada através da uniformidade de dose por conteúdo, sendo o minoxidil a substância quantificada. Como os resultados da uniformidade de dose por conteúdo não demonstraram distribuição normal, utilizaram-se o One way ANOVA e um modelo estatístico não paramétrico para sua avaliação. Considerando-se a média, o desvio padrão (DP), a variância individual de cada grupo e os gráficos de análise de componentes principais (ACP), observou-se que a impregnação que utilizou o glóbulo nº5, a concentração para impregnação de 5% (v/p), graduação alcoólica de 70% (v/v) e técnica "A" apresentou a melhor uniformidade de dose. Quanto à secagem, verificou-se a necessidade do uso de uma fonte de calor.Unitermos: Glóbulos homeopáticos/processo de impregnação. Composição homeopática/avaliação. Dose homeopática/uniformidade de conteúdo.

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Estudo dos fatores impregnação e secagem nas características de glóbulos utilizados em homeopatia

Cited by 2 publications

References 1 publication

Study of the variables which influence the impregnation of globules, compressed tablets and tablet triturates used in homeopathy

Study of the variables which influence the impregnation of globules, compressed tablets and tablet triturates used in homeopathy

Validation of impregnation process for homeopathic globules by spectrophotometric-UV method

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