Development and in vitro evaluation of extended-release theophylline matrix capsules

Capsule Dosage Forms Containing Natural Antioxidant Microcapsules of Cantigi Extract

“…The first-order model kinetics is the best fit with the R2 of 0.9577. This result is consistent with the previous report (Pinheiro et al, 2007). This result differs from an earlier report using capsules containing gelatin nanoparticles of Cantigi extract.…”

Investigations of the Influences of Processing Conditions on the Properties of Spray Dried Chitosan-Tripolyphosphate Particles loaded with Theophylline

“…while the B5 curve in the same figure (i.e., TPP content in the precursor solution = 0.04% (w/v)) shows the slowest drug releasing rate, with 90% of initially loaded TH issued within 5 hours. For comparison's sake, the dissolution profiles of the commercial capsules with prolonged release of TH micro granules in the medium of pH 7.5 was reported to have a rapid releasing rate, with nearly 100% of the initially loaded TH released within one hour 33 .…”

Cellulose and Its Derivatives Use in the Pharmaceutical Compounding Practice

“…HPMC was efficient in controlling the release of theophylline from the matrix of the capsules prepared by compounding. However, extendedrelease capsules containing 100 mg of theophylline (pellets) available in the market did not show prolonged release when submitted to the same test conditions [38].…”

“…The use of sodium carboxymethylcellulose or hydroxypropyl methylcellulose have also been reported in extended or slow-release systems [34][35][36][37][38][39][40]. These systems are most commonly obtained by the simple mixing of the drug with an appropriate inert matrix [39].…”