Investigations of the Influences of Processing Conditions on the Properties of Spray Dried Chitosan-Tripolyphosphate Particles loaded with Theophylline

Wei, Yang; Huang, Yu-Hung; Cheng, Kuo‐Chung; Song, Yen-Ling

doi:10.1038/s41598-020-58184-3

Cited by 31 publications

(21 citation statements)

References 57 publications

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“…However, as shown in Figure 6 , the increase in inlet temperature favored the formation of shrunken-type microparticles due to a faster evaporation rate. Similar observations were previously made by other authors [ 38 , 40 ]. For instance, Wei et al [ 40 ] recently observed that the particle size increased when increasing the liquid flow-rate, whereas the number of indentations increased by increasing the inlet temperature, during the encapsulation of theopylline in STPP-cross-linked chitosan using spray drying.…”

Section: Resultssupporting

confidence: 93%

Microencapsulation of Copper(II) Sulfate in Ionically Cross-Linked Chitosan by Spray Drying for the Development of Irreversible Moisture Indicators in Paper Packaging

et al. 2020

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Copper(II) sulfate-loaded chitosan microparticles were herein prepared using ionic cross-linking with sodium tripolyphosphate (STPP) followed by spray drying. The microencapsulation process was optimal using an inlet temperature of 180 °C, a liquid flow-rate of 290 mL/h, an aspiration rate of 90%, and an atomizing gas flow-rate of 667 nL/h. Chitosan particles containing copper(II) sulfate of approximately 4 µm with a shrunken-type morphology were efficiently attained and, thereafter, fixated on a paper substrate either via cross-linking with STPP or using a chitosan hydrogel. The latter method led to the most promising system since it was performed at milder conditions and the original paper quality was preserved. The developed cellulose substrates were reduced and then exposed to different humidity conditions and characterized using colorimetric measurements in order to ascertain their potential as irreversible indicators for moisture detection. The results showed that the papers coated with the copper(II) sulfate-containing chitosan microparticles were successfully able to detect ambient moisture shown by the color changes of the coatings from dark brown to blue, which can be easily seen with the naked eye. Furthermore, the chitosan microparticles yielded no cytotoxicity in an in vitro cell culture experiment. Therefore, the cellulose substrates herein developed hold great promise in paper packaging as on-package colorimetric indicators for monitoring moisture in real time.

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Section: Resultssupporting

confidence: 93%

Microencapsulation of Copper(II) Sulfate in Ionically Cross-Linked Chitosan by Spray Drying for the Development of Irreversible Moisture Indicators in Paper Packaging

et al. 2020

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“…Spray drying is a technique in which drugs and polymer solutions, suspensions, or emulsions are atomized through a nozzle and injected into hot air (Wei et al, 2020 ) ( Figure 6 ). As the solvent rapidly evaporates, the atomized droplets are transformed into solid particles (Shi et al, 2020 ; Wei et al, 2020 ). The spray drying process usually includes four stages: atomization, droplet mixing with dry gas, solvent volatilization, and product separation, in which the technological conditions and parameters of the atomization process play a decisive role in the droplet size distribution (Ré, 2006 ; Liu et al, 2015 ; Deshmukh et al, 2016 ; Messa et al, 2020 ), such as the selection of atomizer, nozzle pressure, feed or air flow rate, etc (Bowey & Neufeld, 2010 ; Shi et al, 2020 ).…”

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

269

106

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Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocularrelated diseases.

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“…Abu Fara et al [ 8 ] used roller compaction to improve CH powder flow qualities and to make its compression and compaction characteristics compatible for use in industrial pharmaceutical machines. Additionally, there are some on-going trials to extend the use of CH and CHS as excipients in a similar method followed in improving MCC powder flow using spray drying [ 6 , 18 ]. Such studies, show that CH is a suitable solid pharmaceutical excipient.…”

Section: Introductionmentioning

confidence: 99%

Influence of Chitin Source and Polymorphism on Powder Compression and Compaction: Application in Drug Delivery

et al. 2020

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The objective of the research reported herein is to compare the compaction properties of three different chitin extracts from the organisms most used in the seafood industry; namely crabs, shrimps and squids. The foregoing is examined in relation to their polymorphic forms as well as compression and compaction behavior. Chitin extracted from crabs and shrimps exhibits the α-polymorphic form whilst chitin extracted from squid pins displays a β-polymorphic form. These polymorphs were characterized using FTIR, X-ray powder diffraction and scanning electron microscopy. Pore diameter and volume differ between the two polymorphic powder forms. The β form is smaller in pore diameter and volume. Scanning electron microscopy of the two polymorphic forms shows clear variation in the arrangement of chitin layers such that the α form appears more condensed due to the anti-parallel arrangement of the polymer chains. True, bulk and tapped densities of these polymorphs and their mixtures indicated poor flowability. Nevertheless, compression and compaction properties obtained by applying Heckle and Kawakita analyses indicated that both polymorphs are able to be compacted with differences in the extent of compaction. Chitin compacts, regardless of their origin, showed a very high crushing strength with very fast dissolution which makes them suitable for use as fast mouth dissolving tablets. Moreover, when different chitin powders are granulated with two model drugs, i.e., metronidazole and spiramycin they yielded high crushing strength and their dissolution profiles were in accordance with compendial requirements. It is concluded that the source of chitin extraction is as important as the polymorphic form when compression and compaction of chitin powders is carried out.

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Investigations of the Influences of Processing Conditions on the Properties of Spray Dried Chitosan-Tripolyphosphate Particles loaded with Theophylline

Abstract: polymer matrix as a result of the increased size of TH/Chitosan-TPP particles obtained from higher TPP to chitosan ratio, thereby increasing their encapsulation efficiencies.

Cited by 31 publications

References 57 publications

Microencapsulation of Copper(II) Sulfate in Ionically Cross-Linked Chitosan by Spray Drying for the Development of Irreversible Moisture Indicators in Paper Packaging

Microencapsulation of Copper(II) Sulfate in Ionically Cross-Linked Chitosan by Spray Drying for the Development of Irreversible Moisture Indicators in Paper Packaging

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Influence of Chitin Source and Polymorphism on Powder Compression and Compaction: Application in Drug Delivery

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