Antimicrobial and cytotoxic activities screening of some Brazilian medicinal plants used in Governador Valadares district

Brasileiro, Beatriz Gonçalves; Pizziolo, Virgínia Ramos; Raslan, D. S.; Jamal, Claudia Mashrouah; Silveira, Dâmaris

doi:10.1590/s1516-93322006000200004

Cited by 84 publications

(58 citation statements)

References 8 publications

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“…Ethnopharmacological studies have recommended the use of this plant to treat digestive problems. However, P. ornatus leaves have been used by healing men and farmers, in some regions of Brazil, as an antibiotic for the treatment of skin infections (Brasileiro et al 2006, Diaz et al 2010. Ethno veterinary practices using P. ornatus leaves have become very common as a viable and alternative treatment method, as these leaves are safe, easy to obtain, and inexpensive, they can be found on small farms, and they represent a less aggressive method to heal animals.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic activity of Plectranthus ornatus Codd., a Traditional Medicinal Plant

Nascimento

Albuquerque

Oliveira

et al. 2017

An. Acad. Bras. Ciênc.

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The dichloromethane extract of Plectranthus ornatus Codd., a tradicional medicinal plant, showed antibiotic activity with minimum inhibitory concentration (MIC) values of 0.4 mg.mL -1 and 100 percent of biofilm inhibition against Staphylococcus aureus strains isolated from animals with mastitis infections. Based on these antibacterial activities, in addition to ethnopharmacological reports from healing men and farmers in Brazil, an herbal soap was produced from this active extract and was tested both in vitro and in vivo. In vivo assays conducted on these herbal soaps led to results similar to those previously conducted with the active extract. These results indicated the great potential of this plant for use as an excipient by preparing herbal antibacterial soaps as an alternative veterinary medicine aimed at controlling bovine mastitis infections on small Brazilian farms.

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Section: Introductionmentioning

confidence: 99%

Antibiotic activity of Plectranthus ornatus Codd., a Traditional Medicinal Plant

Nascimento

Albuquerque

Oliveira

et al. 2017

An. Acad. Bras. Ciênc.

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“…The pharmacological activities (antispasmodic, soothing, and stomach disorders) of its essential oils have triggered the interest of researchers in establishing their effects which resulted in the detection of other important properties, including the aromatic (Frighetto & Oliveira, 1998) and biological ones (Cáceres et al, 1991;Abad et al, 1997;Alea et al, 1997;Brasileiro et al, 2006). Currently L. alba is a promising plant for the pharmaceutical, aromatic, and perfume industries and may also be indicated for agricultural-chemical industries, due to its proven fungitoxic, insecticidal, and repellent properties (Dubey et al, 1983;Dwivedi & Kishore, 1990;Kishore & Mishra, 1991;Rao et al, 2000;Schwan-Estrada et al, 2000;Ibrahim et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Performance of ginger grass (Lippia alba) for traits related to the production of essential oil

Yamamoto

Colombo

Filho³

et al. 2008

Sci. agric. (Piracicaba, Braz.)

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Lippia alba (Verbenaceae) is a shrub whose essential oil has important biological, pharmacological, and aromatizing properties. To reach the sustained cultivation of new species with economic potential, the present study aimed to evaluate L. alba performance for fresh leaf matter (FM), leaf dry matter (DM), virus symptoms (VS -Cucumber mosaic virus, CMV), oil yield (OY), and oil chemical composition (OC), and to evaluate DM stability and adaptability. Ten genotypes of four chemical groups (chemotypes) were evaluated in six experiments designed as randomized blocks with two plants per plot, over the whole State of São Paulo, Brazil. A 2.0 × 0.4 × 1.6 m spacing was used in Monte Alegre do Sul and Pindorama, while a 1.0 × 0.4 × 0.6 m spacing was used in Campinas, where four experiments were established under different irrigation and fertilization conditions. The genotype effect was significant (p < 0.05) for all traits evaluated, with high leaf productivity of IAC-16 (citral chemotype), best OY means in the linalool and limonene/carvone chemotypes, and susceptibility of the latter chemotype to CMV. The genotype performance oscillations in the six environments were significant for FM and DM, and despite their significance for phytochemical traits (OY and OC), they were of low magnitude. No qualitative variation was detected for OC. The IAC-2 (linalool) and IAC-13 (limonene/carvone) genotypes showed high stability and wide adaptability, and are recommended to establish initial cultivations of this species. This research also indicated genetic sources to start Lippia alba genetic breeding programs. IAC-1 to IAC-4 (linalool), IAC-9 to IAC-11 (myrcene/ camphor), IAC-13 and IAC-14 (limonene/carvone), and IAC-16 (citral). Plants were selected based on differences in plant morphology, oil yield, and the relative proportions of substances in the oil. Six experiments were carried out in three regions of the State of São Paulo (SP), Brazil, in a randomized block design, with four replicates and two plants (clones) per plot. Four experiments were installed in Campinas (22°31' S, 47°02' W, 680 m), representing four environments (E1 -with both fertilization and irrigation; E2 -with fertilization but no irrigation; E3 -no fertilization but with irrigation; E4 -no fertilization nor irrigation). As to fertilization, two sidedressing applications of the 04-14-08 (N, P 2 O 5 , K 2 O) fertilizer were made, and a drip irrigation system was used. A row spacing of 1.0 m was adopted in these four experiments (environments), with 0.4 m between clones and 0.6 m between plots. The other two experiments were carried out in Monte Alegre do Sul (22°24' S, 46°24' W, 760 m) (E5) and Pindorama (21°06' S, 48°32' W, 534 m) (E6), with a row spacing of 2 m, 0.4 m between clones, and 1.6 m between plots, under a sprinkler irrigation system.

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“…Antibacterial activity: The antibacterial action was ascertained by determination of the minimum inhibitory concentration (MIC), according to Brasileiro et al (2006) ), according to the National Committee For Clinical Laboratory Standards (1997). A 0.1 mL aliquot of bacterial suspension containing 10 8 CFC mL -1 was mixed with 100 mL of sterilized solution of Tween 80 (2%) and this mixture was then used in the assay.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Previous results from this study have shown that determination of the minimum inhibitory concentration (MIC), adapted from Brasileiro et al (2006) with modifications, allows quantitative estimation of the antibacterial activity. For this test, several sequential dilutions of the samples with antibacterial activity were incorporated into the medium, added to the bacterium and incubated for 24 hours.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and antibacterial activity of extracts, fractions and isolated substances from the flowers of Acacia podalyriifolia A. Cunn. ex G. Don

Andrade

Carvalho

Cunico

et al. 2010

Braz. J. Pharm. Sci.

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The extracts and fractions from the flowers of A. podalyriifolia were analyzed previously for antibacterial activity using diffusion in disk, Antioxidant properties were evaluated by determining radical scavenging power (DPPH test) and total phenol content was measured (Folin method). The present study describes the in vitro antibacterial (determining minimum inhibitory concentration) and antioxidant activities (by thiobarbituric acid reactive species -TBARS method) for the ethanol extract, dichloromethane and ethyl acetate fractions and two flavanones (naringenin and 5-β-D-glycosyl-naringenin) isolated from the flowers of Acacia podalyriifolia A. Cunn. ex G. Don. The flavanones naringenin and 5-β-D-glycosylnaringenin had not previously been obtained from this species. The most effective antibacterial activity was observed in the ethyl acetate fraction (MIC=0.25 mg mL -1 against Staphylococcus aureus ATCC 6538, MIC = 0.125 mg mL -1 against Staphylococcus epidermidis ATCC 12229, MIC=0.5 mg mL -1 against Streptococcus pyogenes ATCC 19615, Klebsiella pneumoniae ATCC 13883 and Proteus mirabilis ATCC 43071). The evaluated samples showed antioxidant activity on the TBARS test, especially for ethanol extract (1000 ppm), which was the most active (29.43% ± 0.65) followed by ethyl acetate fraction (1000 ppm, 24.84% ± 1,28), both demonstrating higher activity than that presented by ascorbic acid (1000 ppm, 21.73% ± 1.77), although lower than the BHT (1000 ppm 35.15% ± 3.42), both reference compounds. Naringenin and 5-β-D-glycosyl-naringenin demonstrated antioxidant action, but only naringenin inhibited the growth of gram-positive and gram-negative bacteria.Uniterms: Acacia podalyriifolia/qualitative analysis. Acacia podalyriifolia/phytochemistry. Acacia podalyriifolia/antibacterial activity. Acacia podalyriifolia/antioxidant properties. Flavanones. 5-b-Dglycosyl-naringenin. Naringenin.Os extratos e frações de Acacia podalyriifolia foram analisados previamente para a atividade antibacteriana através da difusão em disco e as propriedades antioxidantes foram verificadas pela determinação da capacidade removedora do radical livre DPPH e pela mensuração do conteúdo de fenólicos totais (Método de Folin). O presente estudo descreve as atividades antibacteriana (determinação da concentração inibitória mínima) e antioxidante (espécies reativas do ácido tiobarbitúrico -teste TBARS) para o extrato etanólico e as frações diclorometano e acetato de etila e para duas flavanonas (naringenina e 5-b-D-glicosilnaringenina) isoladas das flores de Acacia podalyriifolia A. Cunn. ex G. Don. As flavanonas naringenina e 5-b-D-glicosil-naringenina ainda não haviam sido obtidas desta espécie. A atividade antibacteriana mais efetiva foi observada com a fração acetato de etila (CIM=0,25 mg/mL contra Staphylococcus aureus ATCC 6538; CIM=0,125 mg/mL, contra Staphylococcus epidermidis ATCC 12229; CIM=0,5 mg/mL contra Streptococcus pyogenes ATCC 19615, Klebsiella pneumoniae ATCC 13883 e Proteus mirabilis ATCC 43071). As amostras avaliadas demonstraram a...

show abstract

Antimicrobial and cytotoxic activities screening of some Brazilian medicinal plants used in Governador Valadares district

Cited by 84 publications

References 8 publications

Antibiotic activity of Plectranthus ornatus Codd., a Traditional Medicinal Plant

Antibiotic activity of Plectranthus ornatus Codd., a Traditional Medicinal Plant

Performance of ginger grass (Lippia alba) for traits related to the production of essential oil

Antioxidant and antibacterial activity of extracts, fractions and isolated substances from the flowers of Acacia podalyriifolia A. Cunn. ex G. Don

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