A comparative evaluation of antibacterial potential of some plants used in indian traditional medicine for the treatment of microbial infections

Chattopadhyay, Rabi Ranjan; Bhattacharyya, S.K.; Medda, C.; Chanda, Sukalpa; Bag, Anwesa

doi:10.1590/s1516-89132009000500009

Cited by 22 publications

(16 citation statements)

References 16 publications

(14 reference statements)

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“…Similar results were obtained in case of M1 bacterium where this microbe was found to be susceptible to S3 extract Chebula extracts S1-S4 were ineffective in inhibiting M3 bacterial growth giving no IZD values. This study is comparable to previously reported results in literature where all the four microbes are effectively inhibited with acetone extract of the plants with variations in IZD values [16].…”

Section: Determination Of Antioxidant Activity Of T Chebula Extractssupporting

confidence: 92%

Therapeutical Effect of Extracts of Terminalia chebula In Inhibiting Human Pathogens and Free Radicals

Singh¹,

Singh²,

Choi³

et al. 2012

IJBBB

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Abstract-In recent years, multiple drug resistance has been developed due to indiscriminate use of existing antimicrobial drugs in the treatment of infectious diseases. Conventional antibiotics are strong medicines, which if not used in precise way may cause harmful effects. The major thrust is to establish alternative antimicrobial agent in order to treat microbial infections with less or no toxic effect to body and less negligible side effects. The herbal medicines have shown potential to overcome the limitation associated with conventional drugs. However, the appropriate choice of source for herbal medicine is also very important. Terminalia chebula possesses potential pharmaceutical activities and used in several Ayurvedic formulations. The study of solvent-free organic (ethylacetate, acetone, methanol of increasing polarity) and aqueous extracts of the fruits of T. chebula, showed the potential to reduce growth of microorganisms, minimizing the risk of infection, while optimizing the conditions to encourage healing. In our study we found, methanol extract as a potential bactericidal and potent antioxidant while aqueous extract showed the least potential as an antimicrobial agent, though a moderate antioxidant. The finding may provide scientific rationale for the use of crude extract of the plant as a new drug compound as potential antioxidant and antimicrobial agent.

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Section: Determination Of Antioxidant Activity Of T Chebula Extractssupporting

confidence: 92%

Therapeutical Effect of Extracts of Terminalia chebula In Inhibiting Human Pathogens and Free Radicals

Singh¹,

Singh²,

Choi³

et al. 2012

IJBBB

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“…This information is important because, according to Romero et al [26], water is usually the main solvent used by traditional healers to prepare plant extracts, an election solvent that can affect the antibacterial activity of the analyzed extracts. The microbial growth inhibition capacity relies on the rich variety of phytochemicals including flavonoids, tannins, coumarins, terpenoids, triterpenes, alkaloids and vegetable oils (such as eucalyptol), and all compounds can be easily isolated by ethanol, which is a suitable solvent for the extraction of bioactive plant materials [27,28]. In fact, it is important to emphasize that traditional healers can easily use alcohol or aguardiente to prepare the macerations employed in phytotherapy.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of five Peruvian medicinal plants against Pseudomonas aeruginosa

Ulloa-Urizar

Aguilar-Luis

Lama-Odría

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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A B S T R A C TObjective: To evaluate the susceptibility of Pseudomonas aeruginosa (P. aeruginosa) in vitro to the ethanolic extracts obtained from five different Peruvian medicinal plants.Methods: The plants were chopped and soaked in absolute ethanol (1:2, w/v). The antibacterial activity of compounds against P. aeruginosa was evaluated using the cupplate agar diffusion method. Results: The extracts from Maytenus macrocarpa ("Chuchuhuasi"), Dracontium loretense Krause ("Jergon Sacha"), Tabebuia impetiginosa ("Tahuari"), Eucalyptus camaldulensis Dehn (eucalyptus), Uncaria tomentosa ("Uña de gato") exhibited favorable antibacterial activity against P. aeruginosa. The inhibitory effect of the extracts on the strains of P. aeruginosa tested demonstrated that Tabebuia impetiginosa and Maytenus macrocarpa possess higher antibacterial activity. Conclusions:The results of the present study scientifically validate the inhibitory capacity of the five medicinal plants attributed by their common use in folk medicine and contribute towards the development of new treatment options based on natural products.

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“…Midlogarithmic phase organisms were harvested by inoculating this culture into 50 ml of fresh broth for additional 2.5 to 3.5 hrs at 37 0 C. The bacteria were then centrifuged, washed and resuspended in 10 mM cold sodium phosphate buffer (pH=7. 4) 12 . The optical density of an aliquot was measured at 620 nm and the concentration of bacteria were standardized (OD 620 0.20= 5 X 10 7 CFU/ml).…”

Section: Leaves Collection and Processingmentioning

confidence: 99%

“…Chemically, these plant-derived biochemicals have unique built-in chirality due to which they act as natural inhibitor or modulator of biologically vital enzymes and receptors, and this is the reason of their being antimicrobial or immunomodulators [2][3][4][5] . Efforts have been going on throughout the world to discover the new individual or combination of old/new antibacterial agents from various kinds of sources such as micro-organisms, animals, and plants.…”

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confidence: 99%

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2017

IJPSR

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Inconsequential use of broad-spectrum antibiotics results in the evolution of multiple drug resistant pathogenic gram-negative bacterial strains which is a global health threat and is responsible for high morbidity and mortality rates. This necessitated the search for new effective and safe treatment strategies. One such successful treatment strategy is combination therapy which comprises cow urine distillate and medicinal plants extract. In the present report, this combination therapy was used against five pathogenic gram-negative bacteria-S. typhimurium, K. pneumoniae, E. coli, E. aerogenes and V. cholerae. It was observed that combination therapy had more profound effect than the individual plant extract against all the bacterial strains at the specified level. Combination therapy with T. erecta plant extract was found to be the most effective which improved the antibacterial effect 2.54 times more against E. coli. Other plants extract also improved their antibacterial potential when used with CUD (R.A.I=1.28 to 2.54). INTRODUCTION: Cell wall of gram-negative bacteria is more complex than gram-positive bacteria, due to an extra outer phospholipidic membrane carrying the lipopolysaccharide components, which makes the cell wall less permeable to antimicrobial substances. Evolution of multidrug-resistant gram-negative bacteria due to incongruous use of broad-spectrum antibiotics is responsible for the 30-70% mortality rate due to treatment failure of hospitalized patients.

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A comparative evaluation of antibacterial potential of some plants used in indian traditional medicine for the treatment of microbial infections

Cited by 22 publications

References 16 publications

Therapeutical Effect of Extracts of Terminalia chebula In Inhibiting Human Pathogens and Free Radicals

Therapeutical Effect of Extracts of Terminalia chebula In Inhibiting Human Pathogens and Free Radicals

Antibacterial activity of five Peruvian medicinal plants against Pseudomonas aeruginosa

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